Skip to main content
SpringerLink
Log in

Investigation of Myocardial Receptors by PET in Heart Diseases

  • Chapter
Clinical efficacy of positron emission tomography

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 12))

Abstract

Changes in number and/or affinity of cardiac neurotransmitter receptors have been associated with myocardial ischemia and infarction, congestive heart failure, cardiomyopathy, as well as diabetes or thyroid-induced heart muscle disease. These alterations of cardiac receptors have been demonstrated in vitro on membrane homogenates from samples collected mainly during surgery or post mortem. The disadvantage of these in vitro binding techniques is that receptors loose their natural environment and their relationships with the other components of the tissue. With the advent of positron emission tomography (PET) it is now possible to obtain noninvasively quantitative determination of regional biochemical processes in the heart.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bristow, M.R. et al. 1986. Beta-1- and beta-2-adrenergic receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta-l-receptor down-regulation in heart failure. Circ. Res., 59, 297–309.

    PubMed  CAS  Google Scholar 

  • Brown, J.H., Goldstein, D., Masters, S.H. 1985. The putative M1 muscarinic receptor does not regulate phosphoinositide hydrolysis: studies with pirenzepine and McN A 343 in chick heart and astrocytoma cells. Mol. Pharmacol., 27, 525–531.

    PubMed  CAS  Google Scholar 

  • Buja, L.M. et al. 1985. Characterization of a potentially reversible increase in beta-adrenergic receptors in isolated, neonatal rat cardial myocytes with impaired energy metabolism. Circ. Res., 57, 640–645.

    PubMed  CAS  Google Scholar 

  • Burgisser, E., De Lean, A., Lefkowitz, R.J. 1982. Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptor by guanine nucleotide. Proc. Natl. Acad. Sci. (USA), 79, 1732–1736.

    Article  CAS  Google Scholar 

  • Charbonneau, P. et al. 1986. Peripheral-type benzodiazepine receptors in the living heart characterized by positron emission tomography. Circulation, 73, 476–483.

    Article  PubMed  CAS  Google Scholar 

  • Davies, L.P., Huston, V. 1981. Peripheral benzodiazepine binding sites in heart and their interaction with dipyridamole. Eur. J. Pharmacol., 73, 209–211.

    Article  PubMed  CAS  Google Scholar 

  • Dormont, D. et al. 1983. Cll ligand binding to adrenergic and muscarinic receptors in the human heart studied in vivo by PET. J. Nucl. Med., 24, P 20.

    Google Scholar 

  • Ehrin, E. etal. In press. Preparation of carbon-11 labeled prazosin, a potent and selective alpha-l-adrenoreceptor antagonist. Int. J. Appl. Rad. Isot.

    Google Scholar 

  • Fields, J.Z. et al. 1978. Cardiac muscarinic cholinergic receptors. Biochemical identification and characterization. J. Biol. Chem., 253, 3251–3258.

    PubMed  CAS  Google Scholar 

  • Golf, S., Hansson, V. 1986. Effects of beta blocking agents on the density of beta-adrenoceptors and adenylate cyclase response in human myocardium: intrinsic sympathomimetic activity favours receptor regulation. Cardiovasc. Res., 20, 637–644.

    Article  PubMed  CAS  Google Scholar 

  • Hirschowitz, B.I. et al. 1984. Subtypes of Muscarinic Receptors. Trends in Pharmacological Sciences. Suppl. Elsevier, Amsterdam.

    Google Scholar 

  • Laduron, P.M. 1984. Criteria for receptor sites in binding studies. Bichochem. Pharmacol., 33, 833–839.

    Article  CAS  Google Scholar 

  • Le Fur, G. et al. 1983. Peripheral benzodiazepine binding sites: effect of PK 11195, l-(2-chlorophenyl)-N-methyl-N-(l-methylpropyl)-3- isoquinolinecarboxamide. I. In vitro studies. Life Sic., 32, 1839–1847.

    Google Scholar 

  • Levy, M.N., Martin, P.J. 1981. Neural regulation of the heart beat. Ann. Rev. Physiol., 43, 443–453.

    Article  CAS  Google Scholar 

  • Maisel, A.S., Motulsky, H.J., Insel, P.A. 1985. Externalization of beta- adrenergic receptors promoted by myocardial ischemia. Science, 230, 183–186.

    Article  PubMed  CAS  Google Scholar 

  • Maziere, M. et al. 1981. In vivo characterization of myocardium muscarinic receptors by positron emission tomography. Life Sci., 29, 2391–2397.

    Article  PubMed  CAS  Google Scholar 

  • Mestre, M. et al. 1985. PK 11195, an antagonist of peripheral benzodiazepine receptors, reduces ventricular arrhythmias during myocardial ischemia and reperfusion in the dog. Eur. J. Pharmacol., 112, 257–260.

    Article  PubMed  CAS  Google Scholar 

  • Mirro, J.M. et al. 1980. Anticholinergic effects of disopyramide and quinidine on guinea pig myocardium mediation by direct muscarinic receptor blockade. Circ. Res., 47, 855–865.

    PubMed  CAS  Google Scholar 

  • Molinoff, P.B. 1984. Alpha- and beta-adrenergic receptor subtypes properties, distribution and regulation. Drugs, 28, (Suppl. 2), 1–15.

    Article  PubMed  CAS  Google Scholar 

  • Motulsky, H.J., Insel, P.A. 1982. Adrenergic receptors in man. Direct identification, physiologic regulation and clinical alterations. New Engl. J. Med., 307, 18–28.

    CAS  Google Scholar 

  • Mukherjee, A. et al. 1983. Differences in myocardial alpha- and beta- adrenergic receptor numbers in different species. Am. J. Physiol., 245, (Heart Circ. Physiol., 14), H957-H961.

    PubMed  CAS  Google Scholar 

  • Mukherjee, A. et al. 1982. Relationship between beta-adrenergic receptor numbers and physiological responses during experimental canine myocardial ischemia. Circ. Res., 50, 735–741.

    PubMed  CAS  Google Scholar 

  • Robberecht, P. et al. 1983. The human heart beta-adrenergic receptors. I. Heterogeneity of the binding sites: Presence of 50% beta-1- and 50% beta-2-adrenergic receptors. Mol. Pharmacol., 24, 169–173.

    PubMed  CAS  Google Scholar 

  • Seto, M. et al. 1986. Beta-adrenergic receptors in the dog heart characterized by 11C-CGP 12177 and PET. J. Nucl. Med., 27, 949.

    Google Scholar 

  • Syrota, A. 1986. In vivo study of receptors for neuromediators with PET. Int. J. Nucl. Med. Biol., 13, 127–134.

    Article  CAS  Google Scholar 

  • Syrota, A. et al. 1985. Muscarinic cholinergic receptor in the human heart evidenced under physiological conditions by positron emission tomography. Proc. Natl. Acad. Sci. (USA), 82, 584–588.

    Article  CAS  Google Scholar 

  • Syrota, A. et al. 1984. Kinetics of in vivo binding of antagonist to muscarinic cholinergic receptor in the human heart studied by positron emission tomography. Life Sci., 35, 937–945.

    Article  PubMed  CAS  Google Scholar 

  • Staehelin, M., Hertel, C. 1983. (3H)CGP-12177, a beta-adrenergic ligand suitable for measuring cell surface receptors. J. Rec. Res., 3, 35–43.

    CAS  Google Scholar 

  • Stiles, G.L., Lefkowitz, R.J. 1984. Cardiac adrenergic receptors. Ann. Rev. Med., 35, 149–164.

    Article  PubMed  CAS  Google Scholar 

  • Stiles, G.L., Taylor, S., Lefkowitz, R.J. 1983. Human cardiac beta- adrenergic receptors: subtype heterogeneity delineated by direct ligand binding. Life Sic., 33, 467–473.

    Article  CAS  Google Scholar 

  • Taniguchi, T., Wang, J.K.T., Spector, S. 1982. 3(H)diazepam binding sites on rat heart and kidney. Biochem. Pharmacol., 31, 589–590.

    Article  PubMed  CAS  Google Scholar 

  • Trifiletti, R.R., Lo, M.M.S., Snyder, S.H. 1984. Kinetic differences between type I and type II benzodiazepine receptors. Mol. Pharmacol., 26, 228–240.

    PubMed  CAS  Google Scholar 

  • Watson, M., Yamamura, H.I., Roeske, W.R. 1986. (3H)pirenzepine and (-)-(3H)-quinuclidinyl benzilate binding to rat cerebral cortical and cardiac muscarinic cholinergic sites. I. Characterization and regulation of agonist binding to putative muscarinic subtypes. J. Pharmacol. Exp. Ther., 237, 411–418.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Département de Biologie du Commissariat à l’Energie Atomique, Service Hospitalier Frédéric Joliot, Orsay, France

    A. Syrota

Authors
  1. A. Syrota
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Max-Planck-Institute for Neurological Research, Cologne, Germany

    W.-D. Heiss , G. Pawlik , K. Herholz  & K. Wienhard , ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1987 ECSC, EEC, EAEC, Brussels-Luxembourg

About this chapter

Cite this chapter

Syrota, A. (1987). Investigation of Myocardial Receptors by PET in Heart Diseases. In: Heiss, WD., Pawlik, G., Herholz, K., Wienhard, K. (eds) Clinical efficacy of positron emission tomography. Developments in Nuclear Medicine, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3345-3_25

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-3345-3_25

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8002-6

  • Online ISBN: 978-94-009-3345-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation