Abstract
Positron emission tomography (PET) represents a new methodology of high research potential in clinical neuropharmacology. It must be realised, however, that an effective utilization of the PET technique requires an interplay with the other approaches available in this area of research. Further, before introducing new applications of PET to man, preclinical studies in larger animals, particularly monkeys, is often a prerequisite.
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References
Bankiewicz, K.S., Oldfield, E.H, Chiueh, C.C., et al. 1986. Hemi-parkinsonism in monkeys after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Life Sci., 39, 7–16.
Farde, L., Hall, IT., Ehrin, E., et al. 1986. Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET. Science, 231, 258–261.
Fowler, J.S., McGregor, R.R., Wolf, A.P., et al. 1986. Regional distribution of monoamine oxidase A and B in human brain using 11-C-suicide inhibitors and positron emission tomography. Submitted to Science.
Fowler, C.J., Wiberg, A., Oreland, L., et al. 1980. The effect of age on the activity and molecular properties of human brain monoamine oxidase. J. Neural. Transm., 49, 1–20.
Hunt, P., Kannengiesser, M.H. and Raynaud, J.P. 1974. Nomifensine: a potent new inhibitor of dopamine uptake into synaptosomes from rat brain corpus striatum. J. Pharmac., 26, 370–371.
Hägglund, J., Aquilonius, S.-M., Eckernäs, S.-A., et al. 1986. Dopamine receptor properties in Parkinson’s disease and Huntington’s chorea evaluated by positron emission tomography using 11-C-N-methyl-spiperone. Acta Neurol. Scand., in press.
Javitch, J.A., Blaustein, R.O. and Snyder, S.H. 1983. 3-H-mazindol binding associated with neuronal dopamine uptake sites in corpus striatum membranes. Eur. J. Pharmacol., 90, 461–462.
Köhler, C., Hall, H., Ögren, S.-O., et al. 1985. Specific in vitro and in vivo binding of 3-H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain. Biochem. Pharmacol., 34, 2251–2259.
Langström, B. 1980. On the synthesis of 11-C-compounds. Thesis Acta Universitatis, Upsaliensis, 555, Uppsala.
Leenders, K.L. 1986. Movement disorders: a study with positron emission tomography. Thesis Vrije University, Rodopi, Amsterdam.
Robinson, J.B. 1985. Stereoselectivity and isoenzyme selectivity of monoamine oxidase inhibitors. Enantiomers of amphetamine, N-methyl-amphetamine and deprenyl. Biochem. Pharmacol., 34, 1105–1108.
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Aquilonius, SM., Hartvig, P., Leenders, K.L., Lundqvist, H., Langström, B., Tedroff, J. (1987). Central Dopaminergic Mechanisms in Monkey and Man Studied by Positron Emission Tomography. In: Heiss, WD., Pawlik, G., Herholz, K., Wienhard, K. (eds) Clinical efficacy of positron emission tomography. Developments in Nuclear Medicine, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3345-3_10
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DOI: https://doi.org/10.1007/978-94-009-3345-3_10
Publisher Name: Springer, Dordrecht
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