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Biology of Stress in Farm Animals: An Integrative Approach pp 39–54Cite as

Effects of Behavioural and Physical Stressors on Immune Responses

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Part of the book series: Current Topics in Veterinary Medicine and Animal Science ((CTVM,volume 42))

Abstract

Research in animals over the past several decades had indicated that the relationship between the effects of physical and behavioral stressors and the immune response was unidirectional and thus, imposition of unfavorable environments could suppress normal antibody and cell mediated responses. Evidence indicated that a significant part of this suppression was mediated through hypothalamic-pituitary-adrenal neuroendocrine pathways. However, research now indicates that this pathway may not be unidirectional; that information also flows from elements of the immune system toward central control. Extrapituitary, extrahypothalamic “ACTH-like” and “β-endorphin-like” peptides are produced by cells of the immune system that may be initiators of immunity and interact with central mechanisms.

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References

  • Arthur, J. R., Boyne, R., Okolow-Zubkowska, M. J. and Hill, H. A. O. 1982. Neutrophils from Se and Cu deficient cattle. In, Trace Elements in Metabolism in Man and Animals. Ed. J. M. Cawthorne, J. Mc C. Howell, and C. L. White.

    Google Scholar 

  • Bellavite, P., Dri, P., Bisiacchi, B. and Patriarca, P. 1977. Catalase deficiency in myeloperoxidase deficience polymorphonuclear leucocytes from chickens.FEBS Letters, 81, 73.

    Article  PubMed  CAS  Google Scholar 

  • Besedovsky, H., Sorkin, E., Keller, M. and Muller, J. 1975. Changes in blood hormone levels during the immune response. Proc. Soc. Exp. Biol. Med., 150, 466–470.

    PubMed  CAS  Google Scholar 

  • Besedovsky, H. P., Del Rey, A., Sorkin, E., DaPrada, M. and Keller, H. H. 1979. Immunoregulation mediated by the sympathetic nervous system. Cell Immunol., 48, 346–355.

    Article  PubMed  CAS  Google Scholar 

  • Besedovsky, H. O., Del Rey, A. and Sorkin, E. 1981. Lymphokine-containing supernatants from con A-stimulated cells increase corticosterone blood levels. J. Immunol., 126, 385–387.

    PubMed  CAS  Google Scholar 

  • Biozzi, G., Mounton, D., Santa-Anna, O. A., Passos, H. C., Gennari, M., Reis, M. H., Ferreira, V. C. A., Heumann, A. M., Bouthaillier, Y., Ibanez, O. M., Stiffel, C. and Siqureia, M. 1979. Genetics of immunoresponsiveness to natural antigens in the mouse. Curr. Top. Microbiol. Immunol., 5, 31–98.

    Google Scholar 

  • Blecha, F. and Kelley, K. W. 1981. Cold stress reduces the acquisition of colostral immunoglobulin in piglets. J. Anim. Sci., 52, 594–600.

    PubMed  CAS  Google Scholar 

  • Blecha, F., Kelley, K. W. and Satterlee, D. G. 1982. Adrenal involvement in the expression of delayed-type hypersensitivity in SRBC and contact sensitivity to DNFB in stressed mice. Proc. Soc. Exp. Biol. Med., 169, 247–252.

    PubMed  CAS  Google Scholar 

  • Braun, W., Masaaki, I., Winchurch, R. and Webb, D. 1971. On the role of cyclic AMP in immune responses. Ann. N.Y. Acad. Sci., 185, 417–422.

    Article  PubMed  CAS  Google Scholar 

  • Brown, K. I. and Nestor, K. E. 1973. Some physiological responses of turkeys selected for high and low adrenal response to cold stress. Poultry Sci., 52, 1948–1954.

    CAS  Google Scholar 

  • Brune, K. and Spitznagel, J. K. 1973. Peroxidaseless chicken leucocytes: isolation arid characterization of antibacterial granules. J. Infect. Dis., 127, 84–88.

    Article  PubMed  CAS  Google Scholar 

  • Colgano, G. L., Jensen, L. S. and Long, P. L. 1984. Effect of selenium on peripheral blood leucocytes of chickens infected with Emeria. Poultry Sci., 63, 1136–1144.

    Google Scholar 

  • Curtis, S. E., Kingdon, D. A. and Drummond, J. G. 1976. Effects of age and cold on pulmonary bacterial clearances in the young pig. Am. J. Vet. Med., 37, 299–301.

    CAS  Google Scholar 

  • Doughtery, T. F. and White, A. 1944. Influence of hormones on lymphoid tissue structure and function. The role of pituitary adrenotrophic hormone in the regulation of lymphocytes and other cellular elements of blood. Endocrinology, 35, 1–12.

    Article  Google Scholar 

  • Dumont, J. E., Willems, C., Van Sande, J. and Neve, P. 1971. Regulation of the release of thyroid hormones: the role of cyclic AMP. Ann. N.Y. Acad. Sci., 185, 291–316.

    Article  PubMed  CAS  Google Scholar 

  • Edens, F. W. and Siegel, H. S. 1975. Adrenal responses in high and low ACTH response lines of chicks during acute heat stress. Gen. Comp. Endocrinol., 25, 64–73.

    Article  PubMed  CAS  Google Scholar 

  • Edens, F. W., Thaxton, P., Morgan, G. W. and Parkhurst, C. R. 1983. Grouping in Japanese quail. 2. Suppression of the humoral immunity. Poultry Sci., 62, 2479–2485.

    CAS  Google Scholar 

  • Fabris, N. W., Pierpaoli, W. and Sorkin, E. 1971. Hormones and immunological capacity. IV. Restorative effects of developmental hormones or of lymphocytes on the immunodeficiency syndrome in dwarf mice. Clin. Exp. Immunol., 2., 227–240.

    Google Scholar 

  • Garren, H. W. and Shaffner, C. S. 1954. Factors concerned in the response of young New Hampshires to muscular fatigue. Poultry Sci., 33, 1095–1104.

    Google Scholar 

  • Garren, H. W. and Shaffner, C. S. 1956. How the period of exposure to different stress stimuli affects the endocrine and lymphatic gland weights of young chicks. Poultry Sci., 35, 266–272.

    Google Scholar 

  • Glick, B. 1957. Experimental modification of the growth of the bursa of Fabricius. Poultry Sci., 36, 18–24.

    Google Scholar 

  • Glick, B. 1967. Antibody and gland studies in cortisone and ACTH-injected birds. J. Immunol., 98, 1076–1084.

    PubMed  CAS  Google Scholar 

  • Glick, B., Day, E. J. and Thompson, D. 1981. Calorie-protein deficiencies and the immune response of the chicken. I. Humoral immunity. Poultry Sci., 60, 2494–2500.

    CAS  Google Scholar 

  • Glick, B., Taylor, R. L., Jr., Martin, D. E., Watabe, D., Day, E. J. and Thompson, D. 1983. Calorie-protein deficiencies and the immune response of the chicken. II. Cell-mediated immunity. Poultry Sci., 62, 1889–1893.

    CAS  Google Scholar 

  • Gould, N. R. and Siegel, H. S. 1981. Viability of and corticosteroid binding in lymphoid cells of various tissues after corticotropin injection. Poultry Sci., 60, 891–893.

    CAS  Google Scholar 

  • Gross, W. B. 1979. Comparison of dose effect of sheep red blood cells on antibody response in two lines of chickens. Avian Dis., 23, 526–530.

    Article  Google Scholar 

  • Gross, W. B. and Siegel, H. S. 1983. Evaluation of heterophili: lymphocyte ratio as a measure of stress in chickens. Avian Dis., 27, 972–979.

    Article  PubMed  CAS  Google Scholar 

  • Gross, W. B. and Siegel, P. Bl 1973. Effects of social stress-and steroids on antibody production. Avian Dis., 12, 807–815.

    Article  Google Scholar 

  • Gross, W. B. and Siegel, P. B. 1975. Immune response to Escherichia coli. Am. J. Vet. Res., 36, 568–571.

    PubMed  CAS  Google Scholar 

  • Henken, A. M., Groote Schaarsberg, A. M. J. and Nieuwland, M. G. B. 1983. The effect of environmental temperature on immune response and metabolism of the young chickens. 3. Effect of environmental temperature on the humoral immune response following injection of sheep red blood cells. Poultry Sci., 62, 51–58.

    CAS  Google Scholar 

  • Henken, A. M., Verstegen, M. W. A., van der Hel, W. and Knol, E. F. 1982. The effect of environemtnal temperature on immune response and metabolism of the young chickens. 6. Effect of environmental temperature on heat production in pullets in relation to feeding level. Proc. 9th Symp. Energy Metab. Farm. Anim., Lillihammer, Norway.

    Google Scholar 

  • Jones, M. T. and Hillhouse, E. W. 1977. Neurotransmitter regulation of corticotropin-releasing factor, in vitro. Ann. N.Y. Acad. Sci., 297, 536–549.

    Article  PubMed  CAS  Google Scholar 

  • Kelley, K. W., Osborne, C. A., Evermann, J. F., Parish, S. M. and Hinrichs, D. S. 1981. Whole blood leukocyte vs. separated mononuclear cell blastogenesis in calves: Time-dependent changes after shipping. Can. J. Comp. Med., 45, 248–258.

    Google Scholar 

  • Kelley, K. W., Osborne, C. A., Evermann, J. F., Parish, S. M. and Gaskins, C. T. 1982. Effect of chronic heat and cold stressors on plasma immunoglobulin and mitogen-induced blastogenesis in calves. J. Dairy Sci., 65, 1514–1528.

    Article  PubMed  CAS  Google Scholar 

  • Krieger, D. T. 1983. Brain peptides: What, when, and Why? Science (Washington, D.C.), 222, 975–985.

    Article  PubMed  CAS  Google Scholar 

  • McCain, H. W., Lamster, I. B., Bonnone, J. M. and Grbic, J. T. 1982. B-endorphin modulates human immune activity via non-opiate receptor mechanisms. Life Sci., 31, 1619–1624.

    Article  PubMed  CAS  Google Scholar 

  • Marsh, J. A., Dietert, R. R. and Combs, G. F., Jr. 1981. Influence of dietary selenium and vitamin E on the humoral immune response of the chick. Proc. Soc. Exp. Biol. Med., 166, 228–231.

    PubMed  CAS  Google Scholar 

  • Meyer, R. K., Aspinall, R. L., Graetzer, M. A. and Wolfe, H. R. 1964. Effect of corticosterone on the skin homograft reaction and on the precipitin and hemagglutinin production in thymectomized chickens. J. Immunol, 92, 466–450.

    Google Scholar 

  • Morgan, G. W., Thaxton, P. and Edens, F. W. 1976. Reduced symptoms of anaphlaxis in chickens by ACTH and heat. Poultry Sci., 55, 1498–1504.

    CAS  Google Scholar 

  • Nir, I., Yam, D. and Perek, M. 1975. Effects of stress on the corticosterone content of the blood plasma and adrenal gland of intact and bursectomized Gallus domesticus. Poultry Sci., 54. 2101–2114.

    CAS  Google Scholar 

  • Oosterlee, C. C., Van Dijk, J. H. C., Metz, J. H. M. and de Wilt, J. C. 1980. Influence of housing systems on the immune response of sows, colostral transfer of antibodies and behavior of piglets. Proc. EAAP Conf., Munich, FRG.

    Google Scholar 

  • Pardue, S. L. and Thaxton, J. P. 1984. Evidence for amelioration of steroid-mediated immunosuppression by ascorbic acid. Poultry Sci., 63, 1262–1269.

    CAS  Google Scholar 

  • Pauling, L. 1976. Vitamin C, The Common Cold and The Flu. W. H. Freeman and Co., San Francisco, CA.

    Google Scholar 

  • Prinz, W., Block, J., Gilich, G. and Mitchell, G. 1980. A systematic study of the effect of vitamin C supplementation on humoral immune response in ascorbate-dependent mammals. Int. J. Vito Nutr. Res., 50, 294–301.

    CAS  Google Scholar 

  • Regnier, J. A. and Kelley, K. W. 1981. Heat-and cold-stress suppresses in vivo and in vitro cellular immune responses of chickens. Am. J. Vet. Res., 42, 294–299.

    PubMed  CAS  Google Scholar 

  • Regnier, J.A., Kelley, K. W. and Gaskins, C. T. 1980. Acute thermal stressors and synthesis of antibodies in chickens. Poultry Sci., 59, 985–990.

    CAS  Google Scholar 

  • Sato, K. and Glick, B. 1970. Antibody and cell mediated immunity in corticosteroid-treated chicks. Poultry Sci., 49, 982–991.

    CAS  Google Scholar 

  • Siegel, H. S. 1980. Physiological stress in birds. Bioscience, 30, 529–534.

    Article  CAS  Google Scholar 

  • Siegel, H. S. and Beane, W. L. 1961. Time responses to Single intramuscular doses of ACTH. Poultry Sci., 40, 216–219.

    CAS  Google Scholar 

  • Siegel, H. S. and Gould, H. R. 1982. High temperature and corticosteroid in the lymphocytes of domestic fowl (Gallus domesticus). Gen. Comp. Endocrinol., 48, 348–354.

    Article  PubMed  CAS  Google Scholar 

  • Siegel, H. S., Gould, N. R. and Latimer, J. W. 1985. Splenic leukocytes from chickens injected with Salmonella pullorum antigen stimulate production of corticosteroids by isolated adrenal cells. Proc. Soc. Exp. Biol. Med., 178, 523–530.

    PubMed  CAS  Google Scholar 

  • Siegel, H. S. and Latimer, J. W. 1975. Social interactions and antibody titers in young male chickens. Anim. Behav., 11, 323–330.

    Article  Google Scholar 

  • Siegel, H.S. and Latimer, J.W., 1984. Interaction of high temperature and Salmonella pullorum antigen concentration on serum agglutinin and corticosteroid responses in White Rock chickens. Poultry Sci, 63, 2483–2491.

    CAS  Google Scholar 

  • Siegel, H. S., Latimer, J. W., and Gould, N. R. 1983. Concentration of Salmonella pullorum antigen and the immunosuppressive effect of ACTH in growing chickens. Poultry Sci., 62, 897–903.

    CAS  Google Scholar 

  • Smith, E. M. and Blalock, J. E. 1981. Human lymphocyte production of corticotropin and endorphin-like substances: Association with leukocyte interferon. Proc. Natl. Acad. Sci. USA, 78, 7530–7534.

    Article  PubMed  CAS  Google Scholar 

  • Smith, E. M., Meyer, W. J. and Blalock, J. E. 1982. Virus-induced corticosterone in hypophysectomized mice: A possible lymphoid-adrenal axis. Science (Washington, D.C.), 218, 1311–1312.

    Article  PubMed  CAS  Google Scholar 

  • Soloman, G. F. 1969. Stress and antibody response in rats. Intl. Arch. Alelrgy, 35, 97.

    Article  Google Scholar 

  • Stott, G. H., Wiersma, F., Menefee, B. E. and Radwanski, F. R. 1976. Influence of environment on passive immunity in calves. J. Dairy Sci., 59. 1306–1312.

    Article  PubMed  CAS  Google Scholar 

  • Subba Rao, D. S. V. and Glick, B. 1977. Effect of cold exposure on the immune response of chickens. Poultry Sci., 56, 992–996.

    CAS  Google Scholar 

  • Sullivan, D. A. and Wira, C. R. 1979. Sex hormone-and glucocorticoid receptor in the bursa of Fabricius of immature chickens. J. Immunol., 122, 2617–2623.

    PubMed  CAS  Google Scholar 

  • Thaxton, P. and Briggs, D. M. 1972. Effect of immobilization and formaldehyde on immunological responsiveness in young chickens. Poultry Sci., 51, 342–344.

    CAS  Google Scholar 

  • Thaxton, P. and Siegel, H. S. 1970. Immunodepression in young chickens by high environmental temperature. Poultry Sci., 49, 202–205.

    CAS  Google Scholar 

  • Thaxton, P. and Siegel, H. S. 1973. Modification of high temperature and ACTH mediated immunosuppression by metryrapone. Poultry Sci., 52, 618–624.

    CAS  Google Scholar 

  • Thompson, D. L., Elgert, K. D., Gross, W. B. and Siegel, P. B. 1980. Cell-mediated immunity in Marek’s disease virus=infected chickens genetically selected for high and low concentrations of plasma corticosterone. Am. J. Vet. Res., 41, 91–96.

    PubMed  CAS  Google Scholar 

  • Thompson, E. B. and Lippman, M. E. 1974. Mechanism of action of glucocortoids. Metabolism, 23, 159–202.

    Article  PubMed  CAS  Google Scholar 

  • Weiss, S. J., Lampert, M. B. and Test, S. T. 1983. Long-lived oxidants generated by human neutrophils: Characterization and bioactivity. Science, 222, 625–626.

    Article  PubMed  CAS  Google Scholar 

  • van der Zijpp, A. J. 1983. The effect of genetic origin, source of antigen, and dose of antigen on the immune response of cockerels. Poultry Sci., 62, 205–211.

    Google Scholar 

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Authors and Affiliations

  1. Department of Poultry Science, The Pennsylvania State University, University Park, PA, 16802, USA

    H. S. Siegel

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  1. H. S. Siegel
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Editors and Affiliations

  1. Department of Animal Husbandry, Agricultural University, Marijkeweg 40, 6709 PG, Wageningen, The Netherlands

    P. R. Wiepkema

  2. Department of Animal Physiology, Agricultural University, Haarweg 10, 6709 PJ, Wageningen, The Netherlands

    P. W. M. Van Adrichem

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© 1987 ECSC, EEC, EAEC, Brussels-Luxembourg

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Siegel, H.S. (1987). Effects of Behavioural and Physical Stressors on Immune Responses. In: Wiepkema, P.R., Van Adrichem, P.W.M. (eds) Biology of Stress in Farm Animals: An Integrative Approach. Current Topics in Veterinary Medicine and Animal Science, vol 42. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3339-2_4

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  • DOI: https://doi.org/10.1007/978-94-009-3339-2_4

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