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HLA-DR3 Molecules are the Products of an HLA Class II Immune Regulator Gene for Mycobacterium Leprae Predisposing to Tuberculoid Leprosy

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Recognition of M. leprae antigens

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 17))

Abstract

Antigen specific immune responses are controlled by polymorphic immune response (Ir) genes. In experimental animals, the majority of these Ir genes has been mapped to the major histocompatibility complex, the MHC (1,2). MHC class II Ir genes have been found to control immune reactivity against T cell dependent foreign antigens. The products of these MHC class II Ir genes are the MHC class II molecules (1,2). Three major mechanisms of MHC class II Ir gene controlled interindividual variability in immune responsiveness have been described: a) differences in the available or selected T cell-antigen receptor repertoire b) differences in the capacity of class II molecules to associate with antigen in order to create an immunogenic complex for T cells, and c) differences in the activation of functionally distinct T cell compartments, e.g. suppressor (Ts) versus helper (Th) cells (2,3).

Tom H.M. Ottenhoff, Di\(\ddot \bar e\)nne G. Elferink, Jenny Kobesen, Derk L. Leiker, Rudy F.M. Lai A Fat and René R.P. de Vries. Submitted for publication.

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Authors and Affiliations

  1. Department of Immunohematology and Blood Bank, University Hospital, Leiden, The Netherlands

    Tom Ottenhoff M.D. & René De Vries M.D.

  2. Armauer Hansen Research Institute, Addis Abeba, Ethiopia

    Tom Ottenhoff M.D.

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  1. Tom Ottenhoff M.D.
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  2. René De Vries M.D.
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© 1987 Martinus Nijhoff Publishers, Dordrecht

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Ottenhoff, T., De Vries, R. (1987). HLA-DR3 Molecules are the Products of an HLA Class II Immune Regulator Gene for Mycobacterium Leprae Predisposing to Tuberculoid Leprosy. In: Recognition of M. leprae antigens. Developments in Hematology and Immunology, vol 17. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3327-9_7

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  • DOI: https://doi.org/10.1007/978-94-009-3327-9_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7994-5

  • Online ISBN: 978-94-009-3327-9

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