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Molecular Localization and Polymorphism of HLA Class II Restriction Determinants Defined By Mycobacterium Leprae Reactive Helper T Cell Clones from Leprosy Patients

  • Chapter
Recognition of M. leprae antigens

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 17))

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Abstract

The activation of helper T lymphocytes requires the recognition of foreign antigen in association with a self HLA class II molecule. This phenomenon is known as HLA class II restriction (1). The polymorphic class II epitopes that are corecognized by helper T cells are functionally defined as restriction determinants (RDs) (2). There are three groups of HLA class II molecules: DP, DQ and DR (3). These molecules are expressed as heterodimeric glycoproteins on the cell surface of immunocompetent cells and are composed of a heavy (α) and a light (β) chain (3). The DP and DQ regions each contain 2 α and 2 β genes whereas the DR region is known to encode 1 α and 3 β (β 1,β 2,β 3) genes (3). It has been reported that RDs for helper T cells are carried by each group of class II products, namely D/DR, DP and DQ (for references see 1,2,4). However, the exact molecules carrying these RDs as well as the epitopes involved have remained poorly characterized.

Tom H.M. Ottenhoff, Saskia Neuteboom, Diënne G. Elferink, & René R.P. de Vries. J. Exp. Med., accepted for publication with minor modifications.

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Authors and Affiliations

  1. Department of Immunohematology and Blood Bank, University Hospital, Leiden, The Netherlands

    Tom Ottenhoff M.D. & René De Vries M.D.

  2. Armauer Hansen Research Institute, Addis Abeba, Ethiopia

    Tom Ottenhoff M.D.

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  1. Tom Ottenhoff M.D.
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  2. René De Vries M.D.
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© 1987 Martinus Nijhoff Publishers, Dordrecht

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Ottenhoff, T., De Vries, R. (1987). Molecular Localization and Polymorphism of HLA Class II Restriction Determinants Defined By Mycobacterium Leprae Reactive Helper T Cell Clones from Leprosy Patients. In: Recognition of M. leprae antigens. Developments in Hematology and Immunology, vol 17. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3327-9_6

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  • DOI: https://doi.org/10.1007/978-94-009-3327-9_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7994-5

  • Online ISBN: 978-94-009-3327-9

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