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Mycobacterium Leprae Specific Protein Antigens Defined by Cloned Human Helper T Cells

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Recognition of M. leprae antigens

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 17))

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Abstract

Leprosy displays a remarkable spectrum of symptoms correlating with the T cell mediated immune reactivity of the host against the causative organism, Mycobacterium leprae (1). At one pole of this spectrum are lepromatous leprosy patients showing a M. leprae specific T cell unresponsiveness (2); at the other pole are tuberculoid leprosy patients displaying both acquired immunity and delayed type hypersensitivity against M. leprae which are thought to be conferred by helper T (Th) cells (1,3–5). Because well defined M. leprae antigens are crucial for the prevention and the control of leprosy (1,6,7), we have cloned M. leprae reactive T cells (TLC) of the helper phenotype from a tuberculoid leprosy patient. As reported here, these TLC show an unexpected diversity in the recognition of M. leprae and related mycobacteria, which is different from that exhibited by monoclonal antibodies (8,9). Half of these TLC are completely or almost M. leprae specific, whereas the other half is crossreactive with most or all other mycobacteria. A M. leprae protein of relative molecular mass (Mr) 36,000 (36K) defined by a M. leprae specific monoclonal antibody (7,8,10) stimulates 4 out of 6 TLC tested. Each of these TLC recognizes a different antigenic determinant, one of which is M. leprae specific.

Tom H.M. Ottenhoff, Paul R. Klatser, Juraj Ivanyi, Diënne G. Elferink, Madeleine Y.L. de Wit and René R.P. de Vries, 1986. Nature 319: 66–68.

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Authors and Affiliations

  1. Department of Immunohematology and Blood Bank, University Hospital, Leiden, The Netherlands

    Tom Ottenhoff M.D. & René De Vries M.D.

  2. Armauer Hansen Research Institute, Addis Abeba, Ethiopia

    Tom Ottenhoff M.D.

Authors
  1. Tom Ottenhoff M.D.
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  2. René De Vries M.D.
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© 1987 Martinus Nijhoff Publishers, Dordrecht

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Ottenhoff, T., De Vries, R. (1987). Mycobacterium Leprae Specific Protein Antigens Defined by Cloned Human Helper T Cells. In: Recognition of M. leprae antigens. Developments in Hematology and Immunology, vol 17. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3327-9_4

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  • DOI: https://doi.org/10.1007/978-94-009-3327-9_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7994-5

  • Online ISBN: 978-94-009-3327-9

  • eBook Packages: Springer Book Archive

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