Abstract
Human helper T-cell clones (TLC) are exquisite tools for obtaining detailed information about which foreign antigenic epitopes and HLA class II restriction determinants are co-recognized by the T-cell receptor (reviewed in Ref. 15). Different techniques for generating TLC have been described, of which cloning under limiting dilution conditions has received most attention (15). For human antigen-specific helper TLC, the requirement for autologous or HLA class II identical antigen-presenting cells (APC) is well documented (see, for example, Refs 3, 4, 17 and 19).
J.B.A.G. Haanen, T.H.M. Ottenhoff, A. Voordouw, B.G. Elferink, P.R. Klatser, H. Spits & R.R.P. de Vries. Scand. J. Immunol. v. 23: 101-108, 1986.
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© 1987 Martinus Nijhoff Publishers, Dordrecht
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Ottenhoff, T., de Vries, R. (1987). HLA Class-II-Restricted Mycobacterium Leprae-Reactive T-Cell Clones from Leprosy Patients Established with a Minimal Requirement for Autologous Mononuclear Cells. In: Recognition of M. leprae antigens. Developments in Hematology and Immunology, vol 17. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3327-9_3
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DOI: https://doi.org/10.1007/978-94-009-3327-9_3
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