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Cellular mechanisms of ventricular arrhythmias in ischemia

  • Chapter
Ventricular Tachycardias

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 71))

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Abstract

The elucidation of the cellular mechanisms of ventricular arrhythmias in ischemia and infarction has been impeded by the inability to monitor readily intracellular potentials in ischemically-injured myocardium in situ. Various approaches to the problem, including recording of intracellular potentials from subepicardial cells in the beating heart with floating micro-electrodes, study of excised ischemically-injured myocardium, and study of excised normal tissues exposed to simulated ischemic conditions, all have limitations and the liability of generation of misleading data and wrong conclusions. Nevertheless, intriguring and perhaps relevant and significant observations have been made of the electrophysiological properties of cells altered by ischemia. Reviews in recent years have surveyed the burgeoning literature dealing with the cellular electrophysiological alteration due to ischemia [1, 2]. In this brief review, certain findings that appear at this time to be important in generation of arrhythmias will be highlighted.

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Authors
  1. Ralph Lazzara
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Editor information

Editors and Affiliations

  1. Department of Cardiology, Hôpital Central, Nancy, France

    Etienne Aliot MD, F.A.C.C. (Professor of cardiology) (Professor of cardiology)

  2. Department of Cardiology, Veterans Administration Medical Center and University of Oklahoma Health Center, Oklahoma City, Oklahoma, USA

    Ralph Lazzara MD, F.A.C.C. (Professor of cardiology) (Professor of cardiology)

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© 1987 Martinus Nijhoff Publishers, Dordrecht

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Lazzara, R. (1987). Cellular mechanisms of ventricular arrhythmias in ischemia. In: Aliot, E., Lazzara, R. (eds) Ventricular Tachycardias. Developments in Cardiovascular Medicine, vol 71. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3323-1_1

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  • DOI: https://doi.org/10.1007/978-94-009-3323-1_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7992-1

  • Online ISBN: 978-94-009-3323-1

  • eBook Packages: Springer Book Archive

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