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Renin-angiotensin system and arterial wall in hypertension

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Book cover Arterial and Venous Systems in Essential Hypertension

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 63))

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Abstract

The renin-angiotensin system is a blood-borne biochemical cascade whose final product, angiotensin II, is a potent vasoconstrictor and a primary stimulus for aldosterone secretion. Numerous studies have demonstrated an important role for this circulating system in blood pressure, and electrolyte and fluid homeostasis. Our understanding of the contribution of the circulating renin-angiotensin system to cardiovascular and renal physiology has been made possible through the development of radioimmunoassay, and availability of synthetic peptides and pharmacologic inhibitors. More recently, using biochemical and molecular biologic techniques, a number of investigators also demonstrated the expression of renin and angiotensinogen genes in a variety of tissues, thus allowing for the possibility of local angiotensin production. As a result of these observations, the concept of the renin-angiotensin system as a hormonal system alone is now in question. Locally expressed renin-angiotensin systems may be involved in the regulation of individual tissue function, independent of the circulating counterpart. This emerging concept may be important in providing additional understanding of the renin-angiotensin system’s role in physiology and the responses to pharmacologic inhibitors.

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Authors
  1. Victor J. Dzau
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Editors and Affiliations

  1. Diagnostic Center, Department of Internal Medicine, Hôpital Broussais, Paris, France

    M. E. Safar

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© 1987 Martinus Nijhoff Publishers, Dordrecht.

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Dzau, V.J. (1987). Renin-angiotensin system and arterial wall in hypertension. In: Safar, M.E., London, G.M., Simon, A.C., Weiss, Y.A. (eds) Arterial and Venous Systems in Essential Hypertension. Developments in Cardiovascular Medicine, vol 63. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3303-3_11

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  • DOI: https://doi.org/10.1007/978-94-009-3303-3_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7983-9

  • Online ISBN: 978-94-009-3303-3

  • eBook Packages: Springer Book Archive

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