Abstract
Multicellular organisms are characterized by the organization of their cells in domains building tissues and organs. Maintenance of the territorial integrity of these domains is under regulatory control not only during embryogenesis but also in adult life. Invasion can be defined as a loss of this territorial integrity: Invasive cells break through the boundary of their tissue of origin and penetrate into the territory of another tissue within the same or in another organ. Most invasive cells have the capacity to break through vessel walls and penetrate into the vessel lumen (intravasation). After transport by the circulation, invasive cells can leave the vessels (extravasation) and lodge at secondary sites to produce metastases. Since metastases are, like primary tumours, invasive, they put cells into a new (second, third, etc.) metastatic cascade.
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© 1986 Martinus Nijhoff Publishers, Dordrecht
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Mareel, M.M., De Bruyne, G.K., Sonnenberg, A., Hilgers, J.O. (1986). Experimental Results on Invasiveness of Mouse Mammary Cells: Clinical Implications?. In: Hollmann, K.H., Verley, J.M. (eds) New Frontiers in Mammary Pathology 1986. Developments in Oncology, vol 49. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3297-5_25
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DOI: https://doi.org/10.1007/978-94-009-3297-5_25
Publisher Name: Springer, Dordrecht
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