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Breast Carcinomas with Neuroendocrine Activity

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New Frontiers in Mammary Pathology 1986

Part of the book series: Developments in Oncology ((DION,volume 49))

Abstract

In 1963 Feyrter and Hartmann described two cases of argyrophilic breast carcinomas and suggested that the tumors were derived from “das Helle-Zellen-Organ”, a diffusely distributed system of argyrophilic clear cells described by Feyrter in 1938, and found to be present in the normal breast by Vogler in 1947. In 1977 Cubilla and Woodruff presented their series of 10 patients with similar tumours and demonstrated small electron dense membrane-bound granules in the 3 cases studied by electron microscopy. A number of hormones had already been detected in homogenates of breast carcinoma tissue or in serum from breast cancer patients, such as ACTH (Liddle et al 1965), PTH (Mavligit et al 1971, Melick et al 1972), HCG (Sheth et. al 1974), calcitonin (Coombes et al 1975, Hillyard et al 1976). Interest in neuroendocrine breast tumours has been increasing by leaps and bounds recently, mainly due to the introduction of new techniques that enable the pathologist to localize hormones and peptides in sections prepared for light and electron microscopy.

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Author information

Authors and Affiliations

  1. Institute for Cancer Research, The Norwegian Radium Hospital, 0310, Montebello, Oslo 3, Norway

    Jahn M. Nesland, Ruth Holm & Jan Vincents Johannessen

  2. The Norwegian Cancer Society, Norway

    Jahn M. Nesland, Ruth Holm & Jan Vincents Johannessen

Authors
  1. Jahn M. Nesland
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  2. Ruth Holm
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  3. Jan Vincents Johannessen
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Editors and Affiliations

  1. International Society against Breast Cancer, Contra Cancrum Mammarium and Marie-Lannelongue Hospital, Le Plessis Robinson, France

    K. H. Hollmann  & J. M. Verley  & 

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© 1986 Martinus Nijhoff Publishers, Dordrecht

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Nesland, J.M., Holm, R., Johannessen, J.V. (1986). Breast Carcinomas with Neuroendocrine Activity. In: Hollmann, K.H., Verley, J.M. (eds) New Frontiers in Mammary Pathology 1986. Developments in Oncology, vol 49. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3297-5_13

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  • DOI: https://doi.org/10.1007/978-94-009-3297-5_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7980-8

  • Online ISBN: 978-94-009-3297-5

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