Abstract
In the 1950’s the concept of pharmacokinetics was introduced into clinical medicine by Dost1. Since then a rapidly increasing understanding of the mechanisms of drug disposition has occurred and has involved into the recognized discipline of clinical pharmacology. Coupled with this increased understanding, the introduction of sensitive assay techniques and computerized data analysis has led to many recent advances in our rational clinical use of drugs. Our knowledge of intravenous anesthestic agents in general, and their use in children in particular, has benefited from these advances in clinical pharmacology.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bartels H: Drug therapy in childhood. What has beed done. Pediatr pharmacol 3:131, 1983.
Fisher DM, O’Keefe C, Stanski DR, Crorinelly R, Miller RD, Gregory GA: Pharmacokinetics and pharmacodynamics of d-tubocurarine in infants, children and adults. Anesthesiology 57:203, 1982.
Davis PJ, Robinson KA, Stiller RL, Cook Dr: Sufentanil kinetics in infants and children. Anesthesiology 63:A472, 1985.
Sorbo S, Hudson RJ, Loomis JC: The pharmacokinetics of thiopental in pediatric surgical patients. Anesthesiology 61:666, 1984.
Morselli PL, Franco-Morselli R, Bossi L: Clinical pharmacokinetics in newborns and infants. Age-related differences and therapeutic implications. Clinical Pharmacokinetics 1:2, 1976.
Greeley WJ, de Bruijn NP, Davis DP: Pharmacokinetics of sufentanil in the pediatric cardiovascular patient. Anesthesiology (in press), 1986.
Breckenridge IM, Digerness SB, Kirklin JW: Validity of concept of increase extracellular fluid after open heart surgery. Surgical Forum 20:169, 1969.
Koren G, Crean P, Klein J, Goresley G, Villamater J, Maeod SM: Sequestration of fentanyl by cardiopulmonary bypass (CPBP). Eur J Clin Pharmacol 27(1):51, 1984.
Holley FO, Ponganis KV, Stanski DR: Effect of cardiopulmonary bypass on the pharmacokinetics of drugs. Clinical Pharmacokinetics 7:234, 1982.
Lowenstein E, Hallowel P, Levine FH: Cardiovascular response to large doses of intravenous morphine in man. N Eng J Med 281:1389, 1969.
Lunn JK, Stanley TH, Eisele J: High-dose fentanyl anesthesia for coronary artery surgery: Plasma fentanyl concentrations and influence of nitrous oxide on cardiovascular responses. Anesth Analg 58:390, 1979.
Davis PJ, Cook DR: Clinical pharmacokinetics of newer anesthetic agents. Clinical Pharmacokinetics 11(1):18, 1986.
Hickey PR, Hansen DD: Fentanyl-and sufentanil-oxygen-pancuronuim anesthesia for cardiac surgery in infants. Anesth Analg 63:117, 1984.
Moore, RA, Yang SS, Micholas KW, Gallagher JD, Clark DLs Hemodynamic and anesthetic effects of sufentanil as the sole anesthetic for pediatric cardiovascular surgery. Anesthesiology 62:725, 1985.
Singleton MA, Rosen JI, Fisher DM: Pharmacokinetics of fentanyl in infants and children. Anesthesiology 61:A440, 1984.
Vanderberghe H, Maeod S, Chuiyanja H, Endinyi L, Soldin S: Pharmacokinetics of intravenous morphine in balanced anesthesia: studies in children. Drug Metab Rev 14(5):887, 1983.
Morselli PL, Rovei N: Placental transfer of pethidine and nor-pethidine and their pharmacokinetics in the newborn. Eur J Clin Pharm 1:25, 1980.
Collins C, Koren G, Crean P, Klein J, Roy WL, Maeod SM: Fentanyl pharmacokinetics and hemodynamic effects in preterm infants during ligation of patent ductus arteriosis. Anesth Analg 64(11):1078, 1985.
Rodnay PA, Hollinger I, Santi A, Nagoshima H: Ketamine for pediatric cardiac anesthesia. Anaesthetist 25(6):259, 1976.
Rane A, Wilson JT: Clinical pharmacokinetics in infants and children. Clin Pharmacokinetics 1(1):2, 1976.
Quaynor H, Corby M, Bjorbman S: Rectal induction of anesthesia in children with methohexatone. Patient acceptability and clinical pharmacokinetics. Br J Anaesth 57(6):573, 1985.
Morray JP, Lynn AM, Stamm S3, Hemdon PS, Kawabori I, Stevenson JG: Hemodynamic effects of ketamine in children with congenital heart disease. Anesth Analg 63(10):895, 1984.
Fisher DK, Cronnely R, Sharma M, Miller RD: Clinical pharmacology of edrophonium in infants and children. Anesthesiology 61(4):428, 1984.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Martinus Nijhoff Publishers, Dordrecht
About this chapter
Cite this chapter
Greeley, W.J. (1987). The Pharmacokinetics and Pharmacodynamics of Intravenous Anesthetic Agents in the Pediatric Cardiovascular Patient. In: Stanley, T.H., Petty, W.C. (eds) Anesthesia, The Heart and the Vascular System. Developments in Critical Care Medicine and Anesthesiology, vol 15. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3295-1_23
Download citation
DOI: https://doi.org/10.1007/978-94-009-3295-1_23
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7979-2
Online ISBN: 978-94-009-3295-1
eBook Packages: Springer Book Archive