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Immune Deficiency Syndrome in Rodents: The Nude Rat

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New Developments in Biosciences: Their Implications for Laboratory Animal Science

Abstract

The athymic nude mutation was first recorded in 1953 in a colony of outbred hooded rats maintained at the Rowett Research Institute, Bucksburn, Aberdeen, U.K., and the symbol rnu for Rowett nude has been assigned to the recessive mutant gene (1). We have introduced the nude mutant in our institute and backcrossed it into the WAG rat strain for 12 generations. Previous studies (1–3) suggest that the athymic nude rat is in many ways very similar to the nude mouse, but the numbers of animals and parameters investigated were limited. Therefore the morphologic characteristics in the nude rat were further defined (4). We here present a survey of our studies of these nude animals during the last 10 years.

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Author information

Authors and Affiliations

  1. Laboratory for Pathology, National Institute of Public Health and Environmental Hygiene, P.O. Box 1, 3720 BA, Bilthoven, The Netherlands

    H. Van Loveren & J. G. Vos

  2. Division of Immunopathology, Department of Internal Medicine and Pathology, University Hospital, Catharijnesingel 101, 3511 GV, Utrecht, The Netherlands

    H. J. Schuurman

Authors
  1. H. Van Loveren
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  2. H. J. Schuurman
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  3. J. G. Vos
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Editor information

Editors and Affiliations

  1. Department of Laboratory Animal Science, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands

    Anton C. Beynen

  2. Preclinical Research and Development, Smith Kline & French Laboratories, Philadelphia, Pennsylvania, USA

    Henk A. Solleveld

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© 1988 Martinus Nijhoff Publishers, Dordrecht

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Van Loveren, H., Schuurman, H.J., Vos, J.G. (1988). Immune Deficiency Syndrome in Rodents: The Nude Rat. In: Beynen, A.C., Solleveld, H.A. (eds) New Developments in Biosciences: Their Implications for Laboratory Animal Science. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3281-4_4

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  • DOI: https://doi.org/10.1007/978-94-009-3281-4_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7973-0

  • Online ISBN: 978-94-009-3281-4

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