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Recognition of Autologous Tumour Cells by Blood Lymphocytes in Patients with Lung Cancer

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Immunology of Malignant Diseases

Part of the book series: Immunology and Medicine ((IMME,volume 6))

Abstract

On the basis of the knowledge which has emerged from experiments with well defined antigens it can be expected that if patients are sensitized against antigens present on their tumour cells, these can activate autologous blood lymphocytes in vitro. Indeed, blastogenesis and generation of cytotoxic lymphocytes have been induced in autologous mixed lymphocyte tumour cell cultures (MLTC). The frequency of positive results varied between 30 and 77% in the different reports (for review see ref. 1). The test conditions used in the different laboratories probably contributed to the variations. In our material of 359 patients, the frequencies varied between 29 and 72%, depending on the histological type of tumours (Table 7.1).

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References

  1. Vánky, F. and Stjernswärd, J. (1979). Lymphocyte stimulation. In Herberman, R. B. and Mclntire, K. R. (eds.) Immunodiagnosis of Cancer. pp. 998–1032. (New York: Marcel Decker)

    Google Scholar 

  2. Opelz, G., Kiuchi, M., Takasugi, M. and Terasaki, P. I. (1975). Autologous stimulation of human lymphocyte subpopulations. J. Exp. Med., 142, 1327–33

    Article  PubMed  CAS  Google Scholar 

  3. Weksler, M. E. and Kozak, R. (1977). Lymphocyte transformation induced by autologous cells. Generation of immunological memory and specificity during the autologous mixed lymphocyte reaction. J. Exp. Med., 146, 1833–8

    Article  PubMed  CAS  Google Scholar 

  4. Vose, B. M., Ferguson, R. and Moore, M. (1982). Mitogen responsiveness and inhibitory activity of mesenteric lymph node cells. Conditionated medium containing T cell growth factor reverses suppressor function. Cancer Immunol. Immunother., 13, 105–11

    Article  PubMed  CAS  Google Scholar 

  5. Akiyama, M., Bean, M. A., Sadamoto, K., Takahashi, Y. and Brankovan, V. (1983). Suppression of the responsiveness of lymphocytes from cancer patients triggered by co-culture with autologous tumor-derived cells. J. Immunol., 131, 3085–90

    PubMed  CAS  Google Scholar 

  6. Klein, E., Vánky, F., Galili, U., Vose, B. M. and Fopp, M. (1980). Separation and characteristics of tumor-infiltrating lymphocytes in man. In Witz, I. P. and Hanna, M. G. Jr.(eds.) Contemporary Topics in Immunobiology. Vol 10, pp. 79–107. (New York: Plenum)

    Google Scholar 

  7. Bøyum, A. (1974). Separation of blood leukocytes, granulocytes and lymphocytes. Tissue Antigens, 4, 269–74

    Article  PubMed  Google Scholar 

  8. Kagan, J. and Choi, Y. S. (1983). Failure of the human autologous mixed lymphocyte reaction in the absence of foreign antigens. Eur. J. Immunol., 13, 1031–6

    Article  PubMed  CAS  Google Scholar 

  9. Timonen, T., Saksela, E., Ranki, A. and Hayry, P. (1979). Fractionation, morphological and functional characterization of effector cells responsible for human natural killer activity against cell line targets. Cell. Immunol., 48, 133–48

    Article  PubMed  CAS  Google Scholar 

  10. Taramelli, D., Fossati, G., Balsari, A., Marolda, R. and Parmiani, G. (1984). The inhibition of lymphocyte stimulation by autologous human metastatic melanoma cells correlates with the expression of HLA-DR antigens on the tumor cells. Int. J. Cancer, 34, 797–806

    Article  PubMed  CAS  Google Scholar 

  11. Herman, J., Kew, M. C. and Rabson, A. R. (1984). Defective interleukin-1 production of monocytes from patients with malignant disease. Interferon increases IL-1 production. Cancer Immunol. Immunother., 16, 182–5

    Article  PubMed  CAS  Google Scholar 

  12. Wood, N., Baskir, H., Greally, J., Amos, D. B. and Yunis, E. J. (1972). Simple method of freezing and storing live lymphocytes. Tissue Antigens, 2, 27–31

    Article  PubMed  CAS  Google Scholar 

  13. Oldham, R. K., Dean, J. H., Cannon, J. B., Ortaldo, J. R., Dunston, G., Applebaum, I., McCoy, L., Djeu, J. and Herberman, R. B. (1976). Cryopreservation of human lymphocyte function as measured by in vitro assays. Int. J. Cancer, 18, 145–55

    Article  PubMed  CAS  Google Scholar 

  14. Vánky, F., Klein, E. and Stjernswärd, J. (1976). Lymphocyte stimulation test for detection of tumour specific reactivity in humans. In Wybran, J. and Staquet, M. (eds.) Clinical Tumor Immunology. pp. 55–8. (Oxford: Pergamon Press)

    Google Scholar 

  15. Fradelizi, D. and Dausset, J. (1975). Mixed lymphocyte reactivity of human lymphocytes primed in vitro. I. Secondary response to allogeneic lymphocytes. Eur. J. Immunol., 5, 295–301

    Article  PubMed  CAS  Google Scholar 

  16. Vánky, F., Klein, E., Stjernswärd, J., Rodriguez, L., Péterffy, Á., Steiner, L. and Nilsonne, U. (1978). Human tumor-lymphocyte interaction in vitro. III. T lymphocytes in autologous tumor stimulation (ATS). Int. J. Cancer, 22, 679–86

    Article  PubMed  Google Scholar 

  17. Grimm, E. A., Vose, B. M., Chu, E. W., Wilson, D. J., Lotze, M. T., Rayner, A. A. and Rosenberg, S. A. (1984). The human mixed lymphocyte-tumor cell interaction test. I. Positive autologous lymphocyte proliferative responses can be stimulated by tumor cells as well as by cells from normal tissues. Cancer Immunol Immunother., 17, 83–9

    Article  PubMed  CAS  Google Scholar 

  18. Natali, P. G., De Martino, C., Quaranta, V., Bigotti, A., Pellegrino, M. A. and Ferrone, S. (1981). Changes in la-like antigen expression on malignant human cells. Immunogenetics, 12, 409–13

    Article  PubMed  CAS  Google Scholar 

  19. Ortaldo, J. R., Seeley, J. M., Mori, N. and Bolhuis, R. L. H. (1984). Responses of human large granular lymphocytes and classical T cells in culture to allogeneic cells, lectins and soluble antigen. J. Leukocyte Biol., 35, 537–48

    PubMed  CAS  Google Scholar 

  20. Meuer, S. C., Schlossman, S. F. and Reinherz, E. L. (1982). Clonal analysis of cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc. Natl Acad. Sci. USA, 79, 4395–9

    Article  PubMed  CAS  Google Scholar 

  21. Damle, N. K., Hansen, E. A., Good, R. A. and Gupta, S. (1981). Monoclonal antibody analysis of human T lymphocyte subpopulations exhibiting autologous mixed lymphocyte reaction. Proc. Natl Acad. Sci. USA, 78, 5096–8

    Article  PubMed  CAS  Google Scholar 

  22. Palacios, R., Llorente, L., Alarcon-Segovia, D., Ruiz-Arguelles, A. and Diaz-Jouanen, E. (1980). Autologous rosette-forming T cells as the responding cells in human autologous mixed lymphocyte reaction. J. Clin. Invest., 65, 1527–30

    Article  PubMed  CAS  Google Scholar 

  23. Landgren, U., Ramstedt, U., Axberg I., Ullberg, M., Jondal, M. and Wigzell, H. (1982). Selective inhibition of human T cell cytotoxicity at levels of target recognition or initiation of lysis by monoclonal OKT3 and Leu2a antibodies. J. Exp. Med., 155, 1579–84

    Article  Google Scholar 

  24. Meuer, S. C., Hussey, R. E., Hogdgon, J. C., Hercend, T., Schlossman, S. F. and Reinherz, E. L. (1982). Structures involved in target recognition by human cytotoxic T lymphocytes. Science (Wash. DC), 218, 471–3

    Article  CAS  Google Scholar 

  25. Moretta, A., Pantaleo, G., Lopez-Botet, M., Mingari, M-C., Carrel, S. and Moretta, L. (1985). Involvement of T11 molecules antigen receptor-mediated T lymphocyte functions: effect of anti-Til monoclonal antibody on functional capabilities of alloreactive T cell clones. Eur. J. Immunol, 15, 841–4

    Article  PubMed  CAS  Google Scholar 

  26. Schlossman, S. F. (1972). Antigen recognition: the specificity of T cells involved in the cellular immune response. Transplant. Rev., 10, 97–134

    PubMed  CAS  Google Scholar 

  27. Zinkernagel, R. M. and Doherty, P. G. (1976). Major transplantation antigens, virus and specificity of surveillance T cells: The ‘altered self’ hypothesis. Contemp. Top. Immunobiol., 7, 179–220

    Google Scholar 

  28. Vánky, F., Klein, E., Willems, J., Böök, K., Ivert, T., Péterffy, A., Nilsonne, U., Kreicbergs, A. and Aparisi, T. (1986). Lysis of autologous tumor cells by blood lymphocytes tested at the time of surgery. Correlation with the postsurgical clinical course. Cancer Immunol. Immunother., 21, 69–76

    Article  PubMed  Google Scholar 

  29. Vánky, F., Argov, S. and Klein, E. (1981). Tumor biopsy cells participating in systems in which cytotoxicity of lymphocytes is generated. Autologous and allogeneic studies. Int. J. Cancer, 27, 273–80

    Article  PubMed  Google Scholar 

  30. Strausser, J. L., Mazumder, A., Grimm, E. A., Lotze, M. T. and Rosenberg, S. A. (1981). Lysis of human solid tumors by autologous cells sensitized in vitro to alloantigens. J. Immunol., 127, 266–71

    PubMed  CAS  Google Scholar 

  31. Vánky, F., Masucci, M. G., Bejarano, M. T. and Klein, E. (1984). Lysis of tumour biopsy cells by blood lymphocytes of various densities. Int. J. Cancer, 33, 185–92

    Article  PubMed  Google Scholar 

  32. Hoshino, T. and Uchida, A. (1984). OK-432 (Picibanil): property, action and clinical effectiveness. In Hoshino, T. and Uchida, A. (eds.) Clinical and Experimental Studies in Immunotherapy, pp. 3–19. (Tokyo: Excerpta Medica)

    Google Scholar 

  33. Uchida, A. and Micksche, M. (1982). Augmentation of human natural killing activity by OK-432. In Herberman, R. B. (ed.) NK Cells and Other Natural Effector Cells, pp. 431–6. (London: Academic Press)

    Google Scholar 

  34. Reinherz, E. L., Acuto, O., Fabbi, M., Bensussan, A., Milanese, C., Royer, H. D., Meuer, S. C. and Schlossman, S. F. (1984). Clonotypic surface structure on human T lymphocytes: functional and biochemical analysis of the antigen receptor complex. Immunol Rev., 81, 95–129

    Article  PubMed  CAS  Google Scholar 

  35. Vanky, F., Klein, E. and Willems, J. (1985). DR antigens expressed on tumor cells do not contribute to the blastogenic response of autologous T cells. Cancer Immunol Immunother., 19, 219–25

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Tumor Biology, Karolinska Institute, 104 01, Stockholm 60, Sweden

    F. Vánky & E. Klein

  2. Department of Tumor Pathology, Karolinska Institute, 104 01, Stockholm, Sweden

    J. Willems

  3. Department of Thoracic Surgery, Karolinska Institute, 104 01, Stockholm, Sweden

    K. Böök, T. Ivert & A. Péterffy

Authors
  1. F. Vánky
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  2. E. Klein
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  3. J. Willems
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  4. K. Böök
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  5. T. Ivert
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  6. A. Péterffy
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Editor information

Editors and Affiliations

  1. Xoma Corporation, Berkeley, California, USA

    V. S. Byers

  2. Cancer Research Campaign Laboratories, University of Nottingham, Nottingham, UK

    R. W. Baldwin

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© 1987 MTP Press Limited

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Vánky, F., Klein, E., Willems, J., Böök, K., Ivert, T., Péterffy, A. (1987). Recognition of Autologous Tumour Cells by Blood Lymphocytes in Patients with Lung Cancer. In: Byers, V.S., Baldwin, R.W. (eds) Immunology of Malignant Diseases. Immunology and Medicine, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3219-7_7

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  • DOI: https://doi.org/10.1007/978-94-009-3219-7_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7945-7

  • Online ISBN: 978-94-009-3219-7

  • eBook Packages: Springer Book Archive

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