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Monoclonal Antibody Targeting of Cytotoxic Agents for Cancer Therapy

  • Chapter
Immunology of Malignant Diseases

Part of the book series: Immunology and Medicine ((IMME,volume 6))

Abstract

The technique of immortalizing individual clones of antibody secreting cells by fusing them with cultured myeloma cells to form hybridomas which continuously secrete antibody has for the first time made possible the reproducible production of antitumour antibodies1–3. Typically these are murine monoclonal antibodies produced by hybridomas formed by fusing splenocytes from mice immunized with human tumour cells or cell fractions. These hybridomas are maintained continuously either in culture or as ascites in mice so allowing production of monoclonal antibodies in multigram amounts. The repertoire of murine monoclonal antibodies which react with human tumours is now quite extensive and preparations are available which recognize almost all of the major types of human cancer1–4. These include antibodies reacting with carcinomas of colon, rectum, breast, ovary, lung and bladder as well as malignant melanoma and bone and soft tissue sarcomas. It is important to recognize, however, that these antibodies generated by immunizing mice with human tumour cells do not recognize tumour specific antigens. Rather, they react with normal or modified tissue antigens which are either preferentially or inappropriately expressed upon malignant cells. One class of antigens, the so-called oncofetal antigens, are tumour cell products which are associated with fetal and malignant tissues5. These include carcinoembryonic antigen (CEA) widely associated with colonic carcinomas6 and α-fetoprotein secreted by hepatocellular carcinomas7.

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Author information

Authors and Affiliations

  1. Cancer Research Campaign Laboratories, University of Nottingham, NG7 2RD, Nottingham, UK

    R. W. Baldwin

  2. Xoma Corporation, 2910 Seventh Street, 94710, Berkeley, California, USA

    V. S. Byers

Authors
  1. R. W. Baldwin
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  2. V. S. Byers
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Editor information

Editors and Affiliations

  1. Xoma Corporation, Berkeley, California, USA

    V. S. Byers

  2. Cancer Research Campaign Laboratories, University of Nottingham, Nottingham, UK

    R. W. Baldwin

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© 1987 MTP Press Limited

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Baldwin, R.W., Byers, V.S. (1987). Monoclonal Antibody Targeting of Cytotoxic Agents for Cancer Therapy. In: Byers, V.S., Baldwin, R.W. (eds) Immunology of Malignant Diseases. Immunology and Medicine, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3219-7_3

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  • DOI: https://doi.org/10.1007/978-94-009-3219-7_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7945-7

  • Online ISBN: 978-94-009-3219-7

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