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Acquired Immune Deficiency Syndrome

  • Chapter
Immunology of Malignant Diseases

Part of the book series: Immunology and Medicine ((IMME,volume 6))

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Abstract

The emergence of the AIDS epidemic in 1980 has led to intense worldwide scientific investigation. Epidemiologic studies had defined the distribution of the disease and its associated risk factors, even before the aetiologic agent was discovered. In 1983 and 1984 French and American investigators identified a retrovirus named LAV or HTLV-III as the aetiologic agent of this disease. Subsequent to this, antibody assays and culture techniques were developed, allowing mass screening for viral exposure, further definition of risk groups and assuring the safety of blood and blood products available for transfusion. The focus of current investigation has been the development of effective antiviral agents and immune modifying strategies as well as anti-HTLV-III/LAV vaccines. Several studies have been ongoing in the treatment of the malignancies, particularly Kaposi’s sarcoma, and opportunistic infections complicating this disease. This chapter, while providing a brief overview of AIDS and its neoplastic complications, will mainly address ongoing research in the treatment of specific aspects of this devastating syndrome.

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Authors and Affiliations

  1. Department of Medicine, Division of Oncology, New York University Medical Center, Old Bellevue Administration Building, 462 First Avenue, 10016, New York, NY, USA

    A. Chachoua & R. Oratz

  2. Department of Hematology/Oncology, Royal Melbourne Hospital, Post Office, 3052, Victoria, Australia

    M. Green

  3. Department of Medical Oncology, USC Comprehensive Cancer Center, 1441 Eastlake Avenue, 90033, Los Angeles, CA, USA

    F. M. Muggia

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  1. A. Chachoua
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  4. F. M. Muggia
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  1. Xoma Corporation, Berkeley, California, USA

    V. S. Byers

  2. Cancer Research Campaign Laboratories, University of Nottingham, Nottingham, UK

    R. W. Baldwin

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Chachoua, A., Oratz, R., Green, M., Muggia, F.M. (1987). Acquired Immune Deficiency Syndrome. In: Byers, V.S., Baldwin, R.W. (eds) Immunology of Malignant Diseases. Immunology and Medicine, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3219-7_11

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