Skip to main content

Menstrual regulation

  • Chapter
Eicosanoids and Reproduction

Part of the book series: Advance in Eicosanoid Research ((AEIR,volume 1))

Abstract

The most prevalent technique for first trimester abortion is suction curettage and was developed to minimize the complications of infection and blood loss encountered with dilatation and sharp curettage. A desire to further reduce these risks coupled with the development of highly sensitive pregnancy tests led to the development of the early suction abortion, which has been variously termed menstrual regulation, menstrual extraction and mini-abortion. Later experience demonstrated that in at least some patients local anaesthesia to minimize vasovagal symptoms and mechanical cervical dilatation could not be avoided. In addition, even with local anaesthesia, 4% had developed endometritis when seen at follow-up, and another 4% required a repeat extraction or suction curettage for incomplete abortion1. In a multicentre study the frequency of pregnancy continuation and incomplete abortion was 4.9% and 3.7% respectively2.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Landesman, R., Kay, R.E. and Wilson, K.H. (1973). Menstrual extraction: a review of 400 procedures at Women’s Services, Hew York, N.Y. Contraception, 8, 527–39

    Article  Google Scholar 

  2. Annual Report, WHO Special Programme of Research, Development and Research Training in Human Reproduction (1979). pp. 60–61

    Google Scholar 

  3. Roth-Brandel, U., Bygdeman, M., Wiqvist, N. and Bergström, S. (1970). Prostaglandins for induction of therapeutic abortion. Lancet, 1, 190

    Article  PubMed  CAS  Google Scholar 

  4. Wiqvist, N. and Bygdeman, M. (1970). Induction of therapeutic abortion with intravenous prostaglandin F2α. Lancet, 2, 889

    Article  Google Scholar 

  5. Bygdeman, M. and Wiqvist, N. (1971). Early abortion in the human.Ann. N.Y. Acad. Sci., 180, 473–82

    Article  PubMed  CAS  Google Scholar 

  6. Karim, S.M.M. and Filshie, G.M. (1970). Therapeutic abortion using prostaglandin F2α. Lancet, 1, 157–9

    Article  PubMed  CAS  Google Scholar 

  7. Karim, S.M.M. (1971). Prostaglandins as abortifacients. N. Engl. J. Med., 285, 1534–5

    Article  PubMed  CAS  Google Scholar 

  8. Kinoshita, K., Wagatsuma, T., Hogaki, M. and Sakamoto, S. (1971). The induction of abortion by prostaglandin F2α. Am. J. Obstet. Gynecol, 111, 855–8

    PubMed  CAS  Google Scholar 

  9. Wentz, A.C. and Jones, G.S. (1973). Intravenous prostaglandin F2α for induction of menses. Fertil Steril, 24, 569–77

    PubMed  CAS  Google Scholar 

  10. Treadway, D. and Mishell, D.R. Jr. (1973). Therapeutic abortion of early human gestation with vaginal suppositories of prostaglandin F2α. Am. J. Obstet. Gynecol, 116 , 795–98

    Google Scholar 

  11. Wiqvist, N. and Bygdeman, M. (1970). Therapeutic abortion by local administration of prostaglandin. Lancet, 2, 716–17

    Article  PubMed  CAS  Google Scholar 

  12. Mocsary, P. and Csapo, A.I. (1975). Menstrual induction with PGF2α and PGE2. Prostaglandins, 10, 545–47

    PubMed  CAS  Google Scholar 

  13. Ragab, M.I. and Edelman, D.A. (1976). Early termination of pregnancy. A comparative study of intrauterine prostaglandin F2α and vacuum aspiration.Prostaglandins, 11, 275

    Article  CAS  Google Scholar 

  14. Mackenzie, I.Z., Hillier, K. and Embrey, M.P. (1976). Intrauterine prostaglandin E2 as an early postconceptional abortifacient. In Samuelsson, B. and Paoletti, R. (eds.) Advances in Prostaglandin and Thromboxane Research. Vol. II., pp. 687–91. (New York: Raven Press)

    Google Scholar 

  15. Bygdeman, M., Martin, J.N. Jr., Leader, A., Lundström, V., Ramadan, M., Eneroth, P. and Gréen, K. (1976). Early pregnancy interruption by 15(S)15-methyl prostaglandin F2α methyl ester. Obstet. Gynecol, 48, 221–4

    PubMed  CAS  Google Scholar 

  16. Hamberger, L., Nilsson, L., Björn-Rasmussen, E., Atterfelt, P. and Wiqvist, N. (1978). Early abortion by vaginal prostaglandin suppositories: blood loss in relation to elimination of serum chorionic gonadotropin, progesterone and estradiol-17β. Contraception, 17, 183–94

    Article  PubMed  CAS  Google Scholar 

  17. Gréen, K., Bygdeman, M. and Bremme, K. (1978). Interruption of early first trimester pregnancy by single vaginal administration of 15-methyl-PGF2α methyl ester.Contraception, 18, 551–60

    Article  PubMed  Google Scholar 

  18. Mandelin, M. (1978). Termination of early pregnancy by a single dose 3 mg 15-methyl PGF2α methyl ester vaginal suppository. Prostaglandins, 16, 143–52

    Article  PubMed  CAS  Google Scholar 

  19. Mackenzie, I.Z., Embrey, M.P., Davies, A.J. and Guillebaud, J. (1978). Very early abortion by prostaglandins. Lancet, 1 , 1223–6

    Article  PubMed  CAS  Google Scholar 

  20. Lundström, V., Bygdeman, M., Fotiou, S., Gréen, K. and Kinoshita, K. (1977). Abortion in early pregnancy by vaginal administration of 16,16-dimethyl-PGE2 in comparison with vacuum aspiration. Contraception, 16 , 167–73

    Article  Google Scholar 

  21. Karim, S.M.M., Ratnam, S.S. and Ilancheran, A. (1977). Menstrual induction with vaginal administration of 16,16-dimethyl trans Δ2-PGE1 methyl ester (ONO-802).Prostaglandins, 14, 615–16

    Article  PubMed  CAS  Google Scholar 

  22. Takagi, S., Sakata, H., Yoshida, T., Den, K., Fujii, T.K., Amenyia, H. and Tornita, M. (1978). Termination of early pregnancy by ONO-802 suppositories (16,16-dimethyl-trans Δ2-PGE1 methyl ester). Prostaglandins, 15, 913–19

    Article  PubMed  CAS  Google Scholar 

  23. Karim, S.M.M., Rao, B., Ratnam, S.S., Prasad, R.N.V., Wong, Y.M. and Ilancheran, A. (1977). Termination of early pregnancy (menstrual induction) with 16-phenoxy-ω-tetranor-PGE2 methyl-sulfonylamide.Contraception, 16, 377–81

    Article  PubMed  CAS  Google Scholar 

  24. Fleischer, A., Schulman, H., Blattner, P., Jagani, N. and Fayemi, A. (1982). Early pregnancy- abortion model using sulprostone. Prostaglandins, 23, 643–55

    Article  PubMed  CAS  Google Scholar 

  25. Bygdeman, M., Christensen, N.J., Gréen, K., Zheng, S. and Lundström, V. (1983). Termination of early pregnancy: future development. Acta Obstet. Gynecol Scand. Suppl, 113, 125–9

    Article  PubMed  CAS  Google Scholar 

  26. Bygdeman, M., Christensen, N.J., Gréen, K. and Vesterqvist, O. (1984). Self-administration at home of prostaglandin for termination of early pregnancy. In Toppozada, M., Bygdeman, M. and Hafez, E.S.E. (eds.) Advances in Reproductive Health Care, pp. 83–90. (Lancaster: MTP)

    Google Scholar 

  27. Rosén, A.S., von Knorring, K., Bygdeman, M. and Christensen, N. (1984). Randomized comparison of prostaglandin treatment in hospital or at home with vacuum aspiration for termination of early pregnancy. Contraception, 29, 423–35

    Article  PubMed  Google Scholar 

  28. WHO Task Force on Post-ovulatory Methods for Fertility Regulation (1986). Menstrual regulation by intramuscular injections of 16-phenoxy-tetranor-PGE2 methyl sulfonylamide or vacuum aspiration. Br. J. Obstet. Gynaecol (in press).

    Google Scholar 

  29. WHO Prostaglandin Task Force (1982). Termination of early first trimester pregnancy by vaginal administration of 16,16-dimethyl-trans-Δ2 PGEX methyl ester. Asia Oceania J. Obstet. Gynaecol, 8 , 263–68

    Google Scholar 

  30. Rosén, A.S., Nystedt, L., Bygdeman, M. and Lundström, V. (1979). Acceptability of a nonsurgical method to terminate very early pregnancy in comparison with vacuum aspiration. Contraception, 19, 107–17

    Article  PubMed  Google Scholar 

  31. Pattison, N.S., Webster, M.A., Phipps, S.L., Anderson, A.B.M. and Gillmer, M.D.G. (1985). Inhibition of 3β-hydroxy steroid dehydrogenase activity in first and second trimester pregnancy and in the luteal phase using Epostane. Fertil Steril, 42, 875–81

    Google Scholar 

  32. Baulieu, E.E. (1985). RU 486: an antiprogestin steroid with contragestive activity in women. In Baulieu, E.E. and Segal, S.J. (eds.) The Antiprogestin RU 486 and Human Fertility Control, pp. 1–26. (New York: Plenum Press)

    Google Scholar 

  33. Herrmann, W., Wyss, R., Riondel, A., Philibert, D., Teutsch, G., Sakiz, E. and Baulieu, E.E. (1982). Effet d’un steroide antiprogesterone chez la femme: interruption du cycle menstruel et de la grossesse au début. C.R. Acad. Sci. Paris, 294 , 933–38

    CAS  Google Scholar 

  34. Kovacs, L., Sas, M., Resch, B.A., Ugocsai, G., Swahn, M.L., Bygdeman, M. and Rowe, P.J. (1984). Termination of very early pregnancy by RU 486 – An anti-progestational compound. Contraception, 24, 399–410

    Article  Google Scholar 

  35. Sitruk-Ware, R., Billaud, L., Mowszowicz, I., Yaneva, H., Mauvais-Jarvis, P., Bardin, C.W. and Spitz, I.M. (1985). The use of RU 486 as an abortifacient in early pregnancy. In Baulieu, E.E. and Segal, S.J. (eds.) The Antiprogestin Steroid RU 486 and Human Fertility Control, pp. 243–48. (New York: Plenum Press)

    Google Scholar 

  36. Birgersson, L., Odlind, V. and Johansson, E. (1985). Clinical effects of RU 486 administered for seven days in early pregnancy. In Baulieu, E.E. and Segal, S.J. (eds.) The Antiprogestin Steroid RU 486 and Human Fertility Control, pp. 235–42. (New York: Plenum Press)

    Google Scholar 

  37. Bygdeman, M. and Swahn, M.L. (1985). Progesterone receptor blockage. Effect on uterine contractility and early pregnancy. Contraception, 32, 45–51

    Article  PubMed  CAS  Google Scholar 

  38. Webster, M.A., Phipps, S.L. and Gillmer, M.D.G. (1985). Interruption of first trimester human pregnancy following Epostane therapy. Effect of prostaglandin E2 pessaries. Br. J. Obstet. Gynaecol, 92 , 963–68

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 MTP Press Limited

About this chapter

Cite this chapter

Bygdeman, M. (1987). Menstrual regulation. In: Hillier, K. (eds) Eicosanoids and Reproduction. Advance in Eicosanoid Research, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3215-9_3

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-3215-9_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7943-3

  • Online ISBN: 978-94-009-3215-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics