Abstract
The protein components of plasma lipoproteins are known as apolipoproteins. The major function of apolipoproteins is lipid transport in the intravascular and extravascular compartments. Many apolipoproteins have, in addition, acquired highly specialized functions. For example, apolipoprotein B (apoB) is an important determinant in the binding of LDL to the LDL receptor [1]. ApoE also appears to confer receptor binding capability to lipoprotein particles to both the LDL receptor [2] and a specific apoE receptor [3]. ApoC-II activates lipoprotein lipase and is important in chylomicron and VLDL metabolism [4,5]. Conversely, apoC-III seems to inhibit the apoC-II activation of lipoprotein lipase [6]. It also modulates the uptake of apoE-containing lipoproteins by liver cells. ApoA-I [7] and possibly apoC-I [8], apoE [9] and apoA-IV [10] are thought to activate lecithin-cholesterol acyltransferase.
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Chan, L., Datta, S., Luo, CC., Li, WH. (1987). Genetic basis of apolipoprotein disorders. In: Lenzi, S., Descovich, G.C. (eds) Atherosclerosis and Cardiovascular Diseases. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3205-0_7
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DOI: https://doi.org/10.1007/978-94-009-3205-0_7
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7938-9
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