Abstract
There is increasing evidence that a hypercoaguable state is a significant risk factor for myocardial infarction (MI), and at autopsy occlusive thrombus has been found in 95% of cases with acute localised infarction[1]. It is not, however, clear if increased tendency to thrombosis is primarily related to the final occlusive event, or if it also plays a significant role in atherogenesis. This paper attempts to bring together recent epidemiological data and studies on haemostatic factors, fibrin and lipoproteins in atherosclerotic lesions.
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References
Davies, MJ and Thomas, A (1984). Thrombosis and acute coronary- artery lesions in sudden cardiac ischemic death. N Engl J Med, 310, 1137
Wilhelmsen, L, Svardsudd, K, Korsan-Bengtsen, K, Larsson, B, Welin, L and Tibblin, G (1984). Fibrinogen as a risk factor for stroke and myocardial infarction. N Engl J Med, 311, 501
Stone, MC and Thorp, JM (1985). Plasma fibrinogen - a major coronary risk factor. J R Coll Gen Pract, 35, 565
Kannel, WB, Castelli, WP and Meeks, SL (1985). Fibrinogen and cardiovascular disease. Amer Coll Cardiol, 34th Ann Scientific Session (Abstract)
Meade, TW, Brozovic, M, Chakrabarti, RR et al (1986). Haemostatic function and ischaemic heart disease: principal results of the Northwick Park heart study. Lancet ii, 533
Lowe, GDO, Drummond, MM, Lorimer, AR et al (1980). Relation between extent of coronary artery disease and blood viscosity. Brit Med J, i, 673
Korsan-Bengsten, K, Wilhelmsen, L and Tibblin, G (1972). Blood coagulation and fibrinolysis in a random sample of 788 men 54 years old: II. Relations of the variables to “risk factors” for myocardial infarction. Thromb Diath Haemor, 28, 99
Meade, TW, Chakrabarti, R, Haines, AP, North, WRS and Stirling, Y (1979). Characteristics affecting fibrinolytic activity and plasma fibrinogen concentrations. Brit Med J, i, 153
Markowe, HLJ, Marmot, MG, Shipley, MJ et al (1985). Fibrinogen: a possible link between social class and coronary heart disease. Brit. Med J, 291, 1312
Elkeles, RS, Chakrabarti, R, Vickers, M, Stirling, Y and Meade, TW (1980). Effect of treatment of hyperlipidaemia on haemostatic variables. Brit Med J 281: 973
Simpson, HCR, Meade, TW, Stirling, Y, Mann, JI, Chakrabarti, R and Woolf, L (1983). Hypertriglyceridaemia and hypercoagulability. The Lancet 1, 786
Miller, GJ, Martin, JC, Webster, J et al (1986). Association between dietary fat intake and plasma Factor VII coagulant activity - a predictor of cardiovascular mortality. Atherosclerosis, 60, 269
Rokitansky, C (1852). A Manual of Pathological Anatomy: Sydenham Society, London, Vol. IV
Duguid, JB (1946). Thrombosis as a factor in the pathogenesis of coronary atherosclerosis. J Pathol Bacteriol 58, 207
Smith, EB (1986). Fibrinogen, fibrin and fibrin degradation products in relation to atherosclerosis. Clin Haematol, 15: 2, 355
Haust, MD (1981). The natural history of human atherosclerotic lesions. In: Moore, S (ed.) “Vascular Injury and Atherosclerosis” p.1. (New York: Marcel Dekker)
Woolf, N (1982) “The Pathology of Atherosclerosis”. (London: Butterworths)
Smith, EB, Staples, EM, Dietz, HS and Smith RH (1979). Role of endothelium in sequestration of lipoprotein and fibrinogen in aortic lesions, thrombi and graft pseudo-intimas. Lancet ii, 812
Smith, EB (1983) Identification of the gelatinous lesion. In: Schettler, G, Gotto, AM, Middelhoff, G, Habernicht, AJR and Jurutka, KR (eds) “Atherosclerosis VI”. p. 170. (Berlin: Springer-Verlag)
Smith, EB and Staples, EM (1982). Intimal and medial plasma protein concentrations and endothelial function. Atherosclerosis, 41, 295
Smith, EB and Staples, E (1981). Haemostatic factors in human aortic intima. Lancet, i, 1171
Smith, EB and Ashall, C (1985). Fibrinolysis and plasminogen concentration in aortic intima in relation to death following myocardial infarction. Atherosclerosis, 55, 171
Smith, EB, Keen, GA, Thompson, WD and Snyder, C (in press). Fibrinogen and FDP in intima in relation to atherogenesis. Proc. Fibrinogen Workshop, Giessen, 1986
Smith, EB (1974). the relationship between plasma and tissue lipids in human atherosclerosis. Advan Lipid Res, 12, 1
Smith, EB and Ashall, C (1983). Low density lipoprotein concentration in interstitial fluid from human atherosclerotic lesions. Biochim Biophys Acta, 754, 249
Smith, EB, Massie, IB and Alexander, KM (1976). The release of an immobilized lipoprotein fraction from atheroslcerotic lesions by incubation with plasmin. Atheroslcerosis 25, 71
Hoff, HF, Heideman, CL, Gotto, AM and Gaubatz, JW (1977). Apoprotein B retention in the grossly normal and atherosclerotic human aorta. Cicrulation Res 41, 684
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Smith, E.B., Keen, G.A. (1987). Haemostatic factors and lipoproteins in atherogenesis. In: Lenzi, S., Descovich, G.C. (eds) Atherosclerosis and Cardiovascular Diseases. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3205-0_41
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DOI: https://doi.org/10.1007/978-94-009-3205-0_41
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7938-9
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