Advertisement

Clinical evaluation of glucagon and insulin in therapy of fulminant hepatitis

  • K. Okita
  • S. Matsuda
  • T. Takemoto
Chapter
  • 19 Downloads

Abstract

Fulminant hepatitis (FH) is defined as a clinical syndrome that develops as a result of massive necrosis of liver cells followed by severe impairment of hepatic function due to viral infection or drugs, in a patient in whom there has been no previous evidence of liver disease. The mortality rate of this condition is extremely high1–3. A nationwide survey conducted in Japan comprising the period 1974–1976, when steroid hormone and/or blood exchange was believed to be useful, revealed a 16.5% survival in FH cases4.

Keywords

Hepatic Encephalopathy Fulminant Hepatic Failure Fulminant Hepatitis Blood Exchange Liver Cell Necrosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Sherlock S, Parbhoo P. The management of hepatic failure. Postgrad Med J 1971; 47: 493–498.PubMedCrossRefGoogle Scholar
  2. 2.
    Trey C, Davidson CS. The management of fulminant hepatic failure. In: Popper H, Schaffner F, eds. Progress in Liver Disease, 3rd edn. New York: Grune & Stratton, 1970: 282–298.Google Scholar
  3. 3.
    Karvoutzis GG, Redeker AG, Peters RL. Long-term follow-up studies on patients surviving fulminant viral hepatitis. Gastroenterology 1974; 67: 870–877.Google Scholar
  4. 4.
    Takahashi Y, Shimizu M, Kosaka M. Nation-wide statistics of fulminant hepatitis (Jap). Saishin Igaku 1979; 34: 2285–2292.Google Scholar
  5. 5.
    Bucher NLR, Swaffield MN. Regulation of hepatic regeneration in rats by synergistic action of insulin and glucagon. Proc Natl Acad Sci USA 1975; 72: 1157–1160.PubMedCrossRefGoogle Scholar
  6. 6.
    Starzl TE, Watanabe K, Porter KA, Putnam CW. Effects of insulin, glucagon and insulin/glucagon infusion on liver morphology and liver cell division after complete portacaval shunt in dogs. Lancet 1976; 1: 821–825.PubMedCrossRefGoogle Scholar
  7. 7.
    Caruana JA, Gage AA. Increased uptake of insulin and glucagon by the liver as a signal for regeneration. Surg Gynecol Obstet 1980; 150: 390–394.PubMedGoogle Scholar
  8. 8.
    Caruana J A, Goldman JK, Camara DS, Gage AA. Insulin, glucagon and glucose in the regeneration response of the liver. Surg Gynecol Obstet 1981; 153: 726–730.Google Scholar
  9. 9.
    Leffert HL, Koch KS, Moran T, Rubalcava B. Hormonal control of rat liver regeneration. Gastroenterology 1979; 76: 1470–1482.PubMedGoogle Scholar
  10. 10.
    McGowan JA, Strain AJ, Bucher NLR. DNA synthesis in primary cultures of adult rat hepatocytes in a defined medium: Effect of epidermal growth factor, insulin, glucagon, and cyclic AMP. J Cell Physiol 1981; 108: 353–363.PubMedCrossRefGoogle Scholar
  11. 11.
    Farivar M, Wands JR, Isselbacher KJ, Bucher NLR. Effect of insulin and glucagon on fulminant murine hepatitis. N Engl J Med 1976; 296: 1517–1519.CrossRefGoogle Scholar
  12. 12.
    Okita K, Noda K, Fukumoto Y, Kodama T, Takemoto T. Protection against liver cell necrosis by synergistic action of glucagon and insulin. Acta Hepatol Japan 1978; 19: 848–853.CrossRefGoogle Scholar
  13. 13.
    Fischer JE, Baldessarini RJ. False neurotransmitters and hepatic failure. Lancet 1971; 2: 75–80.PubMedCrossRefGoogle Scholar
  14. 14.
    Berk PD, Popper H. Fulminant hepatic failure. Am J Gastroenterol 1978; 69: 349–400.PubMedGoogle Scholar
  15. 15.
    Report from the European Association for the Study of the Liver (EASL). Randomized trial of steroid therapy in acute liver failure. Gut 1979; 20: 620–623.CrossRefGoogle Scholar
  16. 16.
    Takahashi Z. Annual report of nation-wide statistics of fulminant hepatitis — 1982, 1983, 1985. (Supported by a Grant-in-Aid from the Japanese Ministry of Health and Welfare.) Personal communication, 1985.Google Scholar

Copyright information

© MTP Press Limited 1987

Authors and Affiliations

  • K. Okita
  • S. Matsuda
  • T. Takemoto

There are no affiliations available

Personalised recommendations