Skip to main content
SpringerLink
Log in

Accumulated experience in the physiology of glucagon

  • Chapter
Book cover Glucagon in 1987

Abstract

Before being a useful spasmolytic and hepatotrophic drug, glucagon is an important hormone exerting major metabolic effects in animals and in man. The explosion of our knowledge of glucagon is reflected by the size of some of the monographs and books devoted to glucagon and published over the last 30 years (Figure 1.1). The last comprehensive book on glucagon was published in 1983, and consists of two volumes totalling 1235 pages1. Most of the data summarized hereafter are developed in detail in the 56 chapters of these volumes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lefèbvre PJ. Glucagon. Handb Exp Pharmacol 66 I and II. Berlin, Heidelberg, New York, Tokyo: Springer, 1983.

    Google Scholar 

  2. Bromer WW. Chemical characteristics of glucagon. In: Lefèbvre PJ, ed. Glucagon I. Handb Exp Pharmacol 66 I. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 1–22.

    Google Scholar 

  3. Merrifield RB, Mojsov S. The chemical synthesis of glucagon. In: Lefèbvre PJ, ed. Glucagon I. Handb Exp Pharmacol 66 I. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 23–25.

    Google Scholar 

  4. Orci L, Bordi C, Unger RH, Perrelet A. Glucagon- and glicentin-producing cells. In: Lefèbvre PJ, ed. Glucagon I. Handb Exp Pharmacol 661. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 57–79.

    Google Scholar 

  5. Lefèbvre PJ, Luyckx AS. Extrapancreatic glucagon and its regulation. In: Lefèbvre PJ, ed. Glucagon II. Handb Exp Pharmacol 66 II Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 205–219.

    Google Scholar 

  6. Hellerström C. Biosynthesis of glucagon. In: Lefèbvre PJ, ed. Glucagon I. Handb Exp Pharmacol 66 I. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 121–138.

    Google Scholar 

  7. Moody AJ, Thim L. Glucagon, glicentin and related peptides. In: Lefèbvre PJ, ed. Glucagon I. Handb Exp Pharmacol 66 I. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 139–174.

    Google Scholar 

  8. Bataille D, Gespach C, Tatemoto K, Marie JC, Caudray AM, Rosselin G, Mutt V. Bioactive enteroglucagon (oxyntomodulin): Present knowledge of its chemical structure and its biological activities. Peptides 1981; 2 (suppl 2): 41–44.

    Article  PubMed  CAS  Google Scholar 

  9. Korànyi L, Peterfy, F, Szabo J, Török A, Guoth M, Tamas GY Jr. Evidence for transformation of glucagon-like immunoreactivity of gut into pancreatic glucagon in vivo. Diabetes 1981; 30: 792–794.

    Article  PubMed  Google Scholar 

  10. Bataille D, Tatemoto K, Gespach H, Jornvall H, Rosselin G, Mutt V. Isolation of glucagon- 37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum. Characterization of the peptide. FEBS Lett 1982; 146: 79–86.

    Article  PubMed  CAS  Google Scholar 

  11. Depigny C, Lupo B, Kervran A, Bataille D. Mise en evidence d’un site récepteur spécifique du glucagon 37 (oxyntomoduline/entero-glucagon bioactif) dans les glandes oxyntiques du rat. CR Acad Sci (Paris) 1984; 299: 677–680.

    CAS  Google Scholar 

  12. Rodbell M. The actions of glucagon at its receptor: regulation of adenylate cyclase. In: Lefèbvre PJ, ed. Glucagon I. Handb Exp Pharmacol 66 I. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 263–290.

    Google Scholar 

  13. Stalmans W. Glucagon and liver glycogen metabolism. In: Lefèbvre PJ, ed. Glucagon I. Handb Exp Pharmacol 66 I Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 291–314.

    Google Scholar 

  14. Claus TH, Park CR, Pilkis SJ. Glucagon and gluconeogenesis. In: Lefèbvre PJ, ed. Glucagon I. Handb Exp Pharmacol 66 I. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 315–360.

    Google Scholar 

  15. McGarry JD, Foster DW. Glucagon and ketogenesis. In: Lefèbvre PJ, ed. Glucagon I. Handb Exp Pharmacol 66 I. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 383–389.

    Google Scholar 

  16. Lefèbvre PJ. Glucagon and adipose tissue lipolysis. In: Lefèbvre PJ, ed. Glucagon I. Handb Exp Pharmacol 66 I. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 419–440.

    Google Scholar 

  17. Korànyi L. Lipolytic effect of glucagon on perfused isolated human fat cells. Diabetologia 1983; 25: 172.

    Google Scholar 

  18. Lefèbvre PJ. Commentary: Glucagon and adipose tissue. Biochem Pharmacol 1975; 24: 1261–1266.

    Article  PubMed  Google Scholar 

  19. Tiengo A, Nosadini R. Glucagon and lipoprotein metabolism. In: Lefèbvre PJ, ed. Glucagon I. Handb Exp Pharmacol 66 I. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 441–451.

    Google Scholar 

  20. Samols E, Marri G, Marks V. Promotion of insulin secretion by glucagon. Lancet 1965: 2: 415–416.

    Article  PubMed  CAS  Google Scholar 

  21. Samols E. Glucagon and insulin secretion. In: Lefèbvre PJ, ed. Glucagon I. Handb Exp Pharmacol 66 I. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 485–518.

    Google Scholar 

  22. Leffert HL, Koch KS, Lad PJ, De Hemptinne B, Skelly H. Glucagon and liver regeneration. In: Lefèbvre PJ, ed. Glucagon I. Handb Exp Pharmacol 66 I. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 453–484.

    Google Scholar 

  23. Kolanowski J. Influence of glucagon on water and electrolyte metabolism. In: Lefèbvre PJ, ed. Glucagon II. Handb Exp Pharmacol 66 II. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 525–536.

    Google Scholar 

  24. Lefèbvre PJ, Luyckx AS. Glucagon and catecholamines. In: Lefèbvre PJ, ed. Glucagon II. Handb Exp Pharmacol 66 II. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 537–543.

    Google Scholar 

  25. Farah AH. Glucagon and the heart. In: Lefèbvre PJ, ed. Glucagon II. Handb Exp Pharmacol 66 I. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 553–609.

    Google Scholar 

  26. Diamant D, Picazo J. Spasmolytic action and clinical use of glucagon. In: Lefèbvre PJ, ed. Glucagon II. Handb Exp Pharmacol 66 II. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 611–643.

    Google Scholar 

  27. Samols E, Weir GC, Bonner-Weir S. Intra-islet insulin-glucagon-somatostatin relationships. In: Lefèbvre PJ, ed. Glucagon II. Handb Exp Pharmacol 66 II. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 133–173.

    Google Scholar 

  28. Paolisso G, Sgambato S, Passariello N, Varrichio M. Scheen A, D’Onoŕrio F, Lefèbvre PJ. Pulsatile insulin delivery is more efficient than continuous infusion in modulating islet-cell function in normal subjects and in patients with type-I diabetes. (Submitted for publication.)

    Google Scholar 

  29. Gerich JE. Glucagon as a counter-regulatory hormone. In: Lefèbvre PJ, ed. Glucagon II. Handb Exp Pharmacol 66 II. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 275–295.

    Google Scholar 

  30. Lickley HLA, Kemmer FW, Wasserman DH, Vranic M. Glucagon and its relationship to other glucoregulatory hormones in exercise and stress in normal and diabetic subjects. In: Lefèbvre PJ, ed. Glucagon II. Handb Exp Pharmacol 66 II. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 297–350.

    Google Scholar 

  31. White NH, Skor DA, Cryer PE, Levandorsky LA, Bier DM. Identification of type-1 diabetic patients at increased risk for hypoglycemia during intensive therapy. N. Engl J Med 1983; 308: 485–491.

    Article  PubMed  CAS  Google Scholar 

  32. Gerich J, Davis J, Lorenzi M, Rizza R, Karam J, Lewis S, Kaplan R, Schultz T, Cryer P. Hormonal mechanisms of recovery from insulin-induced hypoglycemia in man. Am J Physiol 1979; 236: 380–385.

    Google Scholar 

  33. Luyckx AS, Pirnay F, Lefèbvre PJ. Effect of glucose on plasma glucagon and free fatty acids during prolonged exercise. Eur J Appl Physiol 1978; 39: 53–61.

    Article  CAS  Google Scholar 

  34. Lindsey CA, Faloona GR, Unger RH. Plasma glucagon levels during rapid exsanguination with and without adrenergic blockade. Diabetes 1975; 24: 313–319.

    Article  PubMed  CAS  Google Scholar 

  35. Cahill GF Jr. Starvation in man. N Engl J Med 1970; 282: 668–675.

    Article  PubMed  CAS  Google Scholar 

  36. Gelfand RA, Sherwin RS. Glucagon and starvation. In: Lefèbvre PJ, ed. Glucagon II. Handb Exp Pharmacol 66 II Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 223–237.

    Google Scholar 

  37. Girard J, Sperling M. Glucagon in the fetus and the newborn. In: Lefèbvre PJ, ed. Glucagon II. Handb Exp Pharmacol 66 II. Berlin, Heidelberg, New York, Tokyo: Springer, 1983: 251–274.

    Google Scholar 

  38. Foà PP. Galansino G. Glucagon. Chemistry and Function in Health and Disease. Springfield: CC Thomas, 1962.

    Google Scholar 

  39. Lefèbvre P. Le Glucagon, Seconde Hormone Pancréatique. Paris: Maloine, 1967.

    Google Scholar 

  40. Austoni M, Scandellari C, Federspil G, Trisotto A. Current Topics on Glucagon. Padova: CEDAM, 1971.

    Google Scholar 

  41. Lefèbvre PJ, Unger RH. Glucagon. Molecular Physiology, Clinical and Therapeutic Implications. Oxford: Pergamon Press, 1972.

    Google Scholar 

  42. Foà PP, Bajaj JS, Foà NL. Glucagon: Its Role in Physiology and Clinical Medicine. New York, Heidelberg, Berlin: Springer, 1977.

    Google Scholar 

Download references

Authors
  1. P. J. Lefèbvre
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

J. Picazo MD

Rights and permissions

Reprints and permissions

Copyright information

© 1987 MTP Press Limited

About this chapter

Cite this chapter

Lefèbvre, P.J. (1987). Accumulated experience in the physiology of glucagon. In: Picazo, J. (eds) Glucagon in 1987. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3185-5_1

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-3185-5_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7929-7

  • Online ISBN: 978-94-009-3185-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation