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Linear Dichroism and Induced Circular Dichroism for Studying Structure and Interactions of DNA

  • Chapter
Polarized Spectroscopy of Ordered Systems

Part of the book series: NATO ASI Series ((ASIC,volume 242))

Abstract

Linear dichroism (LD) measurements on flow-oriented DNA systems combined with induced circular dichroism (CD) in DNA-adduct chromophores, can provide valuable information about DNA conformation, binding geometry, stereoselectivity and stoichiometry of DNA complexes with drugs and proteins. A prerequisite for a correct interpretation is knowledge of moment directions and absorption intensity distributions of the electronic transitions giving rise to the observed LD and CD effects. This paper will therefore first deal with the problem of determining ultraviolet (u.v.) transition moments of purine and pyrimidine bases and thereafter address a number of structural applications, including studies of DNA conformation (base tilt), binding geometry in DNA complexes with both weak-binding ligands and covalent DNA adducts, and finally also exemplify how information may be gained about organization and stoichiometry in DNA-protein systems.

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Authors and Affiliations

  1. Department of Physical Chemistry, Chalmers University of Technology, S-412 96, Gothenburg, Sweden

    Bengt Nordén & Mikael Kubista

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  1. Bengt Nordén
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  2. Mikael Kubista
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Editors and Affiliations

  1. University of Bologna, Italy

    Bruno Samori’

  2. Royal Danish School of Educational Studies, Denmark

    Erik W. Thulstrup

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© 1988 Kluwer Academic Publishers

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Nordén, B., Kubista, M. (1988). Linear Dichroism and Induced Circular Dichroism for Studying Structure and Interactions of DNA. In: Samori’, B., Thulstrup, E.W. (eds) Polarized Spectroscopy of Ordered Systems. NATO ASI Series, vol 242. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3039-1_6

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  • DOI: https://doi.org/10.1007/978-94-009-3039-1_6

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