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The Formation and Removal of Chemical Mutagens During Drinking Water Treatment

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Organic Micropollutants in the Aquatic Environment
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Summary

The application of bacterial mutagenicity tests to drinking water has shown the presence of mutagens. Invariably, mutagens generated during water treatment chlorination account for much of the mutagenicity detected in most surface-water-derived drinking waters. These mutagens are formed from widespread, naturally occurring precursors, such as humic substances, although other substances, especially amino acids may be involved. Most of the chlorination-derived mutagens identified account for little of the mutagenicity of drinking water. However, one mutagen, MX, is highly potent and may have a significant contribution. Its occurrence and toxicity need full evaluation. Other oxidants/disinfectants, such as ozone and chlorine dioxide, can also generate mutagens but these are likely to differ from those produced by chlorination. Granular activated carbon is effective in removing chlorination-derived mutagens but less effective for precursors. Dechlorinating agents, such as sulphur dioxide, can eliminate some of the mutagens produced by chlorination. The bacterial mutagenicity test cannot give information on the actual risks to health posed by the mutagens. Such information could arise from follow up work on identified major mutagens and from application of other bioassays more indicative of effects in man. Consequently, at the present time it is difficult to justify major changes to treatment practice aimed solely at controlling mutagenicity.

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References

  1. AMES, B.N. (1971). The detection of mutagens with enteric bacteria. A. Hollander (ed), Chemical Mutagens, Principles and Methods of Detection, Vol.1, Plenum Press, 267–282.

    Google Scholar 

  2. FORSTER R. et al. (1983). Use of the fluctuation test to detect mutagenic activity in unconcentrated samples of drinking water in the U.K. R. L. Jolley et al. (eds.), Water Chlorination, Vol. 4, Ann Arbor Scientific Publ. 1189–1197.

    Google Scholar 

  3. WILCOX P. et al. (1986). Isolation and chacterisation of mutagens from drinking water. A. Leonard and M. Kirsch-Volders (eds.), Proceedings of the XVIth Annual Meeting, European Environmental Mutagen Society, 92–103.

    Google Scholar 

  4. FAWELL, J.K. et al. (1986). Health aspects of organics in drinking water. Technical Report TR 231, Water Research Centre, Marlow, Bucks., U.K.

    Google Scholar 

  5. Van der GAAG, M.A. et al. (1985). The influence of water treatment processes on the presence of organic surrogates and mutagenic compounds in water. Sci. Total Environ. 47, 137–153.

    Article  Google Scholar 

  6. KOOL, H.J. and Van KREIJL, C.F. (1984). Formation and removal of mutagenic activity during drinking water preparation. Water Res. 18, 1001–1016.

    Article  Google Scholar 

  7. LOPER, J.C. et al. (1985). Continuous removal of both mutagens and mutagen-forming potential by an experimental full-scale granular activated carbon-treatment system. Environ. Sci. Technol. 19, 333–339.

    Article  CAS  Google Scholar 

  8. Van HOOF, F. et al. (1985). Formation of mutagenic activity during surface water pre-ozonation and its removal in drinking water treatment. Chemosphere 14, 501–509.

    Article  Google Scholar 

  9. BAKER, A. and WILCOX, P. (1987). An investigation on the origin of mutagens in water samples collected from three different sites along a lowland river. Report PRD 1468-M, Water Research Centre, Marlow, Bucks., U.K.

    Google Scholar 

  10. ROOK, J.J. (1974). Formation of haloforms during chlorination of natural waters. Water Treat. Exam. 23, 234–243.

    Google Scholar 

  11. FIELDING, M. et al. (1981). Organic micro-pollutants in drinking water. Technical Report TR 159, Water Research Centre, Marlow, Bucks., U.K.

    Google Scholar 

  12. CHRISTMAN, R.F. et al. (1984). Oxidative degradation of aquatic humic material. Second International Humic Substances Conference, Birmingham.

    Google Scholar 

  13. RECKHOW, D.A. and SINGER, P.C. (1985). Mechanisms of organic halide formation during fulvic acid chlorination and implications with respect to pre-ozonation. R.L. Jolley et al. (eds.), Water Chlorination, Vol.5, Lewis Publ. 1229–1257.

    Google Scholar 

  14. De LEER, E.W.B. et al. (1985). Identification of intermediates leading to chloroform and C-4 diacids in the chlorination of humic acid. Environ. Sci. Technol. 19, 512–522.

    Article  Google Scholar 

  15. FIELDING, M. and HORTH, H. (1986). Formation of mutagens and chemicals during water treatment chlorination. Wat. Supply, 4, 103–126.

    CAS  Google Scholar 

  16. De LEER, E.W.B. et al. (1986). Chlorination of ω-cyanoalkanoic acids in aqueous medium. Environ. Sci. Technol. 20, 1218–1223.

    Article  Google Scholar 

  17. HOLMBOM, B. et al. (1981). Fractionation, isolation and identification of an Ames-mutagenic compound in Kraft chlorination effluents. Tappi 64 (3), 172–174.

    CAS  Google Scholar 

  18. MEIER, J.R. et al. (1986). Mutagenic by-products from chlorination of humic acid. Environ. Health Perspect. 69, 101–107.

    Article  CAS  Google Scholar 

  19. TABOR, M.W. and LOPER, J.C. (1980). Separation of mutagens from drinking water using coupled bioassay/analytical fractionation. Intern. J. Environ. Anal. Chem. 8, 197–215.

    Article  CAS  Google Scholar 

  20. HORTH, H. et al (1987). Techniques for the fractionation and identification of mutagens produced by water treatment chlorination. I.H. Suffet and M. Malaiyandi (eds.). Organic Polutants in Water, Advances in Chemistry Series 214. American Chemical Society.

    Google Scholar 

  21. HORTH, H. et al. (1987). The production of organic chemicals and mutagens during chlorination of amino acids in water. 6th Conference on Water Chlorination, Oak Ridge, Tennessee.

    Google Scholar 

  22. ERTEL, J.R. et al. (1986). Dissolved humic substances of the Amazon river system. Limnol. Oceanogr. 31, 739–754.

    Article  CAS  Google Scholar 

  23. MARUOKA, S. (1986). Analysis of mutagenic by-products produced by chlorination of humic substances by thin layer chromatography and high-performance liquid chromatography. Sci. Total Environ. 54, 195–205.

    Article  CAS  Google Scholar 

  24. HEMMING, J. et al. (1986). Determination of the strong mutagen 3-chloro-4(dichloro-methyl)-5-hydroxy-2(5H)-furanone in chlorinated drinking and humic waters. Chemosphere 15, 549–556.

    Article  Google Scholar 

  25. RAPSON, W.H. et al. (1980). Mutagenicity produced by aqueous chlorination of organic compounds. Bull. Environm. Contam. Toxicol. 24, 590–596.

    Article  CAS  Google Scholar 

  26. HOLMBOM, B. et al. (1987). Formation and properties of 3-chloro-4-(dichloro-methyl)-5-hydroxy-2(5H)-furanone, a potent mutagen in chlorinated waters. 6th Conference on Water Chlorination, Oak Ridge, Tennessee.

    Google Scholar 

  27. ONODERA, S. et al. (1986) Chemical changes of organic compounds in chlorinated water. J. Chromatography 360, 137–150.

    Article  CAS  Google Scholar 

  28. MEIER, J.R. et al. (1983). Formation of mutagens following chlorination of humic acid; a model for mutagen formation during drinking water treatment. Mutation Res. 118, 25–41.

    Article  CAS  Google Scholar 

  29. SUESSMUTH, R. (1982). Genetic effects of amino acids after chlorination. Mutation Res. 105, 23–28.

    Article  CAS  Google Scholar 

  30. RAPSON, W.H. et al. (1985), Mutagenicity produced by aqueous chlorination of tyrosine. R.L.Jolley et al (eds.), Water Chlorination, Vol.5, Lewis Publ., 237–249.

    Google Scholar 

  31. Meier, J.R. et al (1985). Identification of mutagenic compounds formed during chlorination of humic acid. Mutation Res. 157, 111–122.

    Article  CAS  Google Scholar 

  32. KRONBERG, L. et al (1987). Identification of the strong mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and of its geometric isomer E-2-chloro-3-(dichloromethyl)-4-oxo-butenoic acid in mutagenic fractions of chlorine treated humic water and in drinking water. 6th Conference on Water Chlorination, Oak Ridge, Tennessee.

    Google Scholar 

  33. STROEMBERG, L.M. et al (1987). An abundant chlorinated furanone in the spent chlorination liquor from pulp bleaching. Environ. Sci. Technol. 21, 754–756.

    Article  CAS  Google Scholar 

  34. MEIER, J.R. et al. Studies on the potent bacterial mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone: aqueous stability, XAD recovery and analytical determination in drinking water and in chlorinated humic acid solutions. Mutation Res., in press.

    Google Scholar 

  35. KRONBERG, L. et al (1986). Determination of the strong mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and identification of other chlorinated compounds present in mutagenic fractions of chlorinated humic water. A. Leonard and M. Kirsch-Volders (eds.), Proceedings of the XVIth Annual Meeting, European Environmental Mutagen Society, 104–107.

    Google Scholar 

  36. NORWOOD, D.L. et al (1987). Structural characterisation of aquatic humic material. Environ. Sci. Technol., 21, 791–798.

    Article  CAS  Google Scholar 

  37. BACKLUND P et al (1985). Mutagenic activity in humic water treated with alternative disinfectants. H.A.M. de Kruijf and H.J. Kool (eds.), Organic Micropollutants in Drinking Water and Health. Elsevier, 257–264.

    Google Scholar 

  38. COGNET, L. et al (1986). Mutagenic activity of disinfection by-products. Environ. Health Persp. 69, 165–175.

    Article  CAS  Google Scholar 

  39. LYKENS, B.W. et al (1986). Chemical products and toxicologic effects of disinfection. Jour. Amer. Wat. Wks. 78, 66–75.

    Google Scholar 

  40. MONARCO, S. et al (1983). Removal of mutagens from drinking water by granular activated carbon. Water Res. 9, 1015–1026.

    Article  Google Scholar 

  41. CHEH, A.M. et al (1980). Nonvolatile mutagens in drinking water. Science 20, 90–92.

    Article  Google Scholar 

  42. WILCOX, P. and DENNY, S. (1985). Effect of dechlorinating agents on the mutagenic activity of chlorinated water samples. R.L.Jolley et al (eds.), Water Chlorination, Vol.5, Lewis Publ. 1341–1353.

    Google Scholar 

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© 1988 ECSC, EEC, EAEC, Brussels and Luxembourg

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Fielding, M., Horth, H. (1988). The Formation and Removal of Chemical Mutagens During Drinking Water Treatment. In: Angeletti, G., Bjørseth, A. (eds) Organic Micropollutants in the Aquatic Environment. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2989-0_37

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  • DOI: https://doi.org/10.1007/978-94-009-2989-0_37

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7843-6

  • Online ISBN: 978-94-009-2989-0

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