Skip to main content

The Cellular Source of Antibody: A Review

  • Chapter
The Form of Information in Science

Part of the book series: Boston Studies in the Philosophy of Science ((BSPS,volume 104))

  • 94 Accesses

Abstract

From the time of the earliest awareness of the existence of immunity against infectious agents in the animal body, much interest was focussed on the source of this effect, and on the substances responsible for it, primarily antibodies. In the course of this search some major organ and cell systems of the animal body were considered as possible sites for the production of these vital substances, which are essential for the body to withstand infection.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Arneth, J. Die qualitative Blutlehre. Leipzig, 1920. Werner Klinkhardt.

    Google Scholar 

  • Bjørneboe, M. and Gormsen, H. Experimental studies on the role of plasma cells as antibody producers. Acta path. et microbiol. Scandinav. 20, 649, 1943.

    Article  Google Scholar 

  • Bjørneboe, M., Gormsen, H. and Lundquist, F. Further experimental studies in the role of the plasma cells as antibody producers. J. Immunol. 55, 121, 1947.

    Google Scholar 

  • Burnet, F.M. and Lush, D. Influenza virus on the developing egg. VIII. A comparison of two antigenically dissimilar strains of human influenza virus after full adaptation to the egg membrane. Australian J. Exper. Biol. Med. Sci. 16, 261, 1938.

    Article  Google Scholar 

  • Chase, M.W. The cellular transfer of cutaneous hypersensitivity to tuberculin. Proc. Soc. Exper. Biol. Med. 59, 134, 1945.

    Google Scholar 

  • Chase, M.W. Development of antibody following transfer of cells taken from lymph nodes of sensitized or immunized animals. Federation Proc. 10, 404, 1951.

    Google Scholar 

  • Chase, M.W. Immunological reactions mediated through cells. In: Pappenheimer, A.M., Jr. The nature and significance of the antibody response. New York 1953. Columbia University Press.

    Google Scholar 

  • Coons, A.H. and Kaplan, M.H. Localization of antigen in tissue cells: improvement in the method for detection of antigen by means of flourescent antibody. J. Exper. Med. 91, 1, 1950.

    Article  Google Scholar 

  • Coons, A.H., Leduc, E.H. and Connolly, J.M. Studies on antibody production. I. A method for the histochemical demonstration of specific antibody and its application to a study of the hyperimmune rabbits. J. Exper. Med. 102, 49, 1955.

    Article  Google Scholar 

  • Craddock, C.G., Valentine, W.N. and Lawrence, J.S. The lymphocyte. J. Lab & Clin. Med. 34, 158, 1949.

    Google Scholar 

  • Cunningham, A.J., Smith, J.B. and Mercer, E.H. Antibody formation by single cells from lymph nodes and efferent lymph of sheep. J. Exper. Med. 124, 701, 1966.

    Article  Google Scholar 

  • Dougherty, T.F., Chase J.H. and White A. The demonstration of antibodies in lymphocytes. Proc. Soc. Exper. Biol. & Med. 67, 295, 1944.

    Google Scholar 

  • Ehrich, W.E., Drabkin, D.L. and Forman C. Nucleic acids and the production of antibody by plasma cells. J. Exper. Med. 90, 157, 1949.

    Article  Google Scholar 

  • Ehrich, W.E. and Harris, T.N. The formation of antibodies in the popliteal lymph node in rabbits. J. Exper. Med. 76, 335, 1942.

    Article  Google Scholar 

  • Fagreus, A. The plasma cellular reaction and its relation to the formation of antibodies in vitro. J. Immunol. 58, 1, 1948.

    Google Scholar 

  • Glimstedt, G. Bakterienfreie Meerschweinchen; Aufzucht, Lebensfahigkeit und Wachstum, nebst Untersuchungen uber das lymphatische Gewebe. Acta. path. et microbiol. Scandinav. (suppl. 30), 1–295, 1936.

    Google Scholar 

  • Gudat, F.G., Harris, T.N., Harris, S. and Hummeler, K. Studies on antibody-producing cells. I. Ultrastructure of 19S and 7S antibody-producing cells. J. Exper. Med. 132, 448, 1970.

    Article  Google Scholar 

  • Gudat, F.G., Harris, T.N., Harris S. and Hummeler, K. Studies of antibody-producing cells. II. Appearance of 3H-thymidine labeled rosette forming cells. J. Exper. Med. 133, 305, 1971a.

    Article  Google Scholar 

  • Gudat, F.G., Harris, T.N., Harris, S. and Hummeler, K. Studies on antibody-producing cells. III. Identification of young plaque-forming cells by 3H-thymidine labeling. J. Exper. Med. 134, 1155, 1971b.

    Article  Google Scholar 

  • Habel, K., Endicott, K.M., Bell, J.F. and Spear, F. Immunologic evidence on the role of the lymphocyte in antibody formation. J. Immunol. 61, 131, 1949.

    Google Scholar 

  • Harris, S. and Harris, T.N. Influenzal antibodies in lymphocytes of rabbits following the local injection of virus. J. Immunol. 61, 193, 1949.

    Google Scholar 

  • Harris, S. and Harris, T.N. Development of reticulum cells and lymphocytes in transplants of rabbit lymph node to chick chorioallantois. Proc. Soc. Exper. Biol. & Med. 74, 142, 1950.

    Google Scholar 

  • Harris, S. and Harris, T.N. Transfer of cells from lymph nodes of rabbits following regional injection of antigens. Federation Proc. 10, 409, 1951.

    Google Scholar 

  • Harris, S. and Harris, T.N. Studies on the transfer of lymph nodes cells. III. Effects of variation in the interval between the injection of antigen into the donor and collection of its lymph node cells. J. Exper. Med. 100, 269, 1954.

    Article  Google Scholar 

  • Harris, T.N., Grimm, E., Mertens, E. and Ehrich, W.E. The role of the lymphocyte in antibody formation. J. Exper. Med. 81, 73, 1945.

    Article  Google Scholar 

  • Harris, T.N. and Harris, S. Histochemical changes in lymphocytes during the production of antibodies in lymph nodes of rabbits. J. Exper. Med. 90, 169, 1949.

    Article  Google Scholar 

  • Harris, T.N. and Harris, S. Biological and technical factors in the demonstration of antibody production by lymphatic tissue. J. Immunol. 64, 45, 1950.

    Google Scholar 

  • Harris, T.N., Harris, S. and Farber, M.B. Studies on the transfer of lymph node cells. I. Appearance of antibody in recipients of cells from donor rabbits injected with antigen. J. Immunol. 72, 148, 1954.

    Google Scholar 

  • Harris, T.N., Harris, S. and Farber, M.B. Studies on the transfer of lymph node cells. VIII. The transfer of cells from blood and peritoneal exudates incubated in vitro with antigenic material derived from Shigella paradysenteriae. J. Exper. Med. 104, 663, 1956.

    Article  Google Scholar 

  • Harris, T.N., Harris, S., Hummeler, K. and Farber, M.B. Ultrastructure of plaque forming cells of efferent lymph. Proceedings of the Sixth Annual Leucocyte Culture Conference. Edited by Roy O. Schwartz. Published by Academic Press, New York, p. 397, 1972.

    Google Scholar 

  • Harris, T.N., Hummeler, K. and Harris, S. Electron microscopic observations on antibody-producing lymph node cells. J. Exp. Med. 123, 161, 1966.

    Article  Google Scholar 

  • Hartley, G. The local formation of antivaccinial antibodies by the skin. J. Infect. Dis. 66, 44, 1940.

    Article  Google Scholar 

  • Hayes, S.P., Dougherty, T.F. and Gebhardt, L.P. A method for the demonstration of tissue antibody. Proc. Soc. Exper. Biol. & Med. 76, 460, 1951.

    Google Scholar 

  • Hektoen, L. The influence of the x-ray on the production of antibodies. J. Infect. Dis. 17, 415, 1915.

    Article  Google Scholar 

  • Hellman, T. and White, G. Das Verhalten des lymphatischen Gewebes wahrend eines Immunisierungsprozesses. Virchow’s Arch. 278, 221, 1930.

    Article  Google Scholar 

  • Huebschmann, P. Das Verhalten der Plasmazellen in der Milz bei infectiosen Prozessen. Verhandl. d. deutsch. path. Gesellsch. 16, 110, 1913.

    Google Scholar 

  • Hummeler, K., Harris, T.N., Harris, S. and Farber, M.B. Studies on antibody-producing cells. IV. Ultrastructure of plaque-forming cells of rabbit lymph. J. Exper. Med. 135, 491, 1972.

    Article  Google Scholar 

  • Ingraham, J.S. and Bussard, A. Applicaton of a localized hemolysin reaction for specific detection of individual antibody-forming cells. J. Exper. Med. 119, 667, 1964.

    Article  Google Scholar 

  • Jerne, N.K. and Nordin, A.A Plaque formation in agar by single antibody-producing cells. Science 140, 405, 1963.

    Article  Google Scholar 

  • Keuning, F.J. and Van der Slikke, L.B. The role of immature plasma cells, lymphoblasts, and lymphocytes in the formation of antibodies, as established in tissue culture experiments. J. Lab. & Clin. Med. 36, 167, 1950.

    Google Scholar 

  • Klein. Beitrage zur cytologischen Untersuchung der Spinalflussigkeit. Ztschr. f. d. ges Neurol. u. Psychiat. 21, 242, 1914.

    Article  Google Scholar 

  • Kolough, F. Origin of bone marrow plasma cell associated with allergic and immune states in the rabbit. Proc. Soc. Exper. Biol. & Med. 39, 147, 1938.

    Google Scholar 

  • Leduc, E.H., Avrameas, S. and Bouteille, M. Ultrastructural localization of antibody in differentiating plasma cells. J. Exper. Med. 127, 109, 1968.

    Article  Google Scholar 

  • Leduc, E.H. Coons, A.H. and Connolly, J.M. Studies on antibody production. II. The primary and secondary responses in the popliteal lymph node of the rabbit. J. Exper. Med. 102, 61, 1955.

    Article  Google Scholar 

  • Marshall, A.H.E. and White, R.G. Reactions of the reticular tissues to antigens. Brit. J. Exper. Path. 31, 157, 1950.

    Google Scholar 

  • McGregor, D.D. and Gowans, J.L. The antibody response of rats depleted of lymphocytes by chronic drainage from the thoracic duct. J. Exper. Med. 117, 303, 1963.

    Article  Google Scholar 

  • McMaster, P.D. and Hudack, S.S. The formation of agglutinins within lymph nodes. J. Exper. Med. 61, 783, 1935.

    Article  Google Scholar 

  • McMaster, P.D. and Kidd, J.G. Lymph nodes as a source of neutralizing principle for vaccinia. J. Exper. Med. 66, 73, 1937.

    Article  Google Scholar 

  • Mitchison, N.A. Studies on the immunological response to foreign tumor transplants in the mouse. I. The role of lymph node cells in conferring immunity by adoptive transfer. J. Exper. Med. 102, 157, 1955.

    Article  Google Scholar 

  • Moeschlin, S. and Demiral, B. Antikorperbildung der Plasmazellen in vitro. Klin. Wochnschr. 30, 827, 1952.

    Article  Google Scholar 

  • Movat, H.Z. and Fernando, N.V.P. The fine structure of the lymphoid tissue during antibody formation. Exper. and Mol. Path. 4, 155, 1965.

    Article  Google Scholar 

  • Murphy, J.B. and Sturm, E. A comparison of the effects of x-ray and dry heat on antibody formation. J. Exper. Med. 41, 245, 1925.

    Article  Google Scholar 

  • Neher, G.H., and Seigel, B.V. Ultrastructure and development of plaque forming cells from Balb/c mice. Federation Proc. 28, 3092, 1969.

    Google Scholar 

  • Oesterlind, G. Die Reaktion des lymphatischen Gewebes wahrend der Ausbildung der Immunitat gegen Diphtherietoxin. Acta. Path. et microbiol. Scandinav. (suppl. 34), 1–39, 1938.

    Google Scholar 

  • Rebuck, J.W., Harris, T.N. and Harris, S. Quantitation and classification of lymph node cells transferred from rabbits injected with antigens to recipient rabbits. Federation Proc. 12, 400, 1953.

    Google Scholar 

  • Reiss, E., Mertens, E. and Ehrich, W.E. Agglutination of bacteria by lymphoid cells in vitro. Proc. Soc. Exper. Biol. & Med. 74, 732, 1950.

    Google Scholar 

  • Rich, A.R., Lewis, M.R. and Wintrobe, M.M. The activity of the lymphocyte in the body’s reaction to foreign protein, as established by the identification of the acute splenic tumor cell. Bull. Johns Hopkins Hosp. 65, 311, 1939.

    Google Scholar 

  • Ringertz, N. and Adamson, CA. The lymph-node response to various antigens. Acta. Path. et microbiol. Scandinav. (suppl. 86), 1–69, 1950.

    Google Scholar 

  • Roberts, J.C. and Dixon, F.J. The transfer of lymph node cells in the study of the immune response to foreign proteins. J. Exper. Med. 102, 379, 1955.

    Article  Google Scholar 

  • Roberts, J.C, Dixon, F.J. and Weigle, W.O. Antibody-producing lymph node cells in peritoneal exudate cells: morphologic study of transfer to immunologically inert rabbits. Arch. Path. 64, 324, 1957.

    Google Scholar 

  • Sabin, F.B. Cellular reactions to a dye-protein with a concept of the mechanism of antibody formation. J. Exper. Med. 70, 67, 1939.

    Article  Google Scholar 

  • Soloviev, V.D. and Giadamovich, S.Y. The significance of lymph and other elements of the lymphatic system in antiviral immunity. Am. Rev. Soviet Med. 4, 226, 1946.

    Google Scholar 

  • Stavitsky, A.B. Participation of the popliteal lymph node and spleen in the production of antitoxin in the rabbit. J. Infect. Dis. 94, 306, 1954.

    Article  Google Scholar 

  • Storb, U., Chambers, V., Storb, R. and Weiser, R.S. Antibody-carrying cells in the immune response. II. Ultrastructure of “rosette”-forming cells. J. Reticuoendothel. Soc. 4, 69, 1967.

    Google Scholar 

  • Thorbecke, G.J. and Keuning, FJ. Antibody formation in vitro by haemopoietic organs after subcutaneous and intravenous immunization. J. Immunol. 70, 129, 1953.

    Google Scholar 

  • Wager, O.A. and Chase, M.W. Appearance of diptheria antitoxin following transfer of cells taken from immunized rabbits. Federation Proc. 11, 485, 1952.

    Google Scholar 

  • Yoffey, J.M. and Courtice, F.C. Lymphatics, lymph and the lymphomyeloid complex. Academic Press, New York, 1970, pp. 572–588.

    Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Kluwer Academic Publishers

About this chapter

Cite this chapter

Harris, T.N., Harris, S. (1989). The Cellular Source of Antibody: A Review. In: The Form of Information in Science. Boston Studies in the Philosophy of Science, vol 104. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2837-4_8

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-2837-4_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7777-4

  • Online ISBN: 978-94-009-2837-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics