Abstract
Over the past few years developments in the field of mass spectrometry occurred which opened it to areas of research previously completely inaccessible. First was the discovery by Barber et al. (1981) of a novel ionization technique, fast atom bombardment (FAB), which suddenly made it possible to ionize large, polar and thermally labile molecules. Prior to that time, such compounds had to be degraded into smaller molecules and/or chemically transformed to compounds that could be volatilized into the mass spectrometer. By using FAB it now became possible to ionize, generally in the form of protonated molecular ions, (M + H)+, compounds of molecular weight of a few thousand daltons which, however, exceeded the mass range of the then commercially available mass spectrometers.
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Keywords
- High Performance Liquid Chromatography
- Tandem Mass Spectrometry
- Collision Induce Dissociation
- Fast Atom Bombardment
- Homo Serine
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 1988 Martinus Nijhoff Publishers, Dordrecht
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Biemann, K. (1988). Recent developments in high mass and tandem mass spectrometry. In: Beecher, G.R. (eds) Research Instrumentation for the 21st Century. Beltsville Symposia in Agricultural Research, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2748-3_18
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DOI: https://doi.org/10.1007/978-94-009-2748-3_18
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