Abstract
An extensive literature documents the efficacy of combination chemotherapy in locally advanced and metastatic sarcomas (1–3). Response rates in larger studies range from 20–60%, but complete remission rates are rarely above 15%. The most effective combinations generally contain Doxorubicin and Dacarbazine (DTIC), which were, until recently, the most active single agents. Average response rates, in collected series (3) for Adriamycin were 24% (range 16–41) and DTIC 17.5% (range 15–25). An analogue of Cyclophosphamide, Ifosfamide has shown promising results producing remission rates ranging from 18–38%, with an average of 28% (3,4).
A Preliminary Report from the Canadian Sarcoma Group/ National Cancer Institute of Canada Clinical Trials Group.
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© 1988 Kluwer Academic Publishers
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Bramwell, V., Eisenhauer, E. (1988). A Pilot Study of Adriamycin, Dacarbazine and Ifosfamide in Advanced Adult Soft Tissue Sarcomas. In: Ryan, J.R., Baker, L.O. (eds) Recent Concepts in Sarcoma Treatment. Developments in Oncology, vol 55. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2691-2_26
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DOI: https://doi.org/10.1007/978-94-009-2691-2_26
Publisher Name: Springer, Dordrecht
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