Abstract
The interaction between four cyclodextrins (α-, β -, dimethyl- β-, and hydroxypropyl- β-cyclodextrin with four antimycotic imidazole derivatives (bifonazol, clotrimazol, miconazol, and tioconazol) was studied. The aqueous solubility of the drugs was increased to different extent, dependent on both the type of CD and type of antimycotic. The observed increase in solubility ranged from three fold for the combination of clotrimazol with α-CD, to almost 2000 fold for the combination of bifonazol with hydroxypropyl- β-CD. Complexes of the antimycotics with β-CD appeared to possess a low, if any, antimicrobial activity. The antimycotic drugs were more readily released from topical preparations containing β-CD than from the same vehicles without β-CD.
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© 1988 Kluwer Academic Publishers
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van Doorne, H., Bosch, E.H., Lerk, C.F. (1988). Interactions between Cyclodextrins and Some Antimycotic Imidazole Derivatives: Studies on Solubility and Antimicrobial Activity. In: Huber, O., Szejtli, J. (eds) Proceedings of the Fourth International Symposium on Cyclodextrins. Advances in Inclusion Science, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2637-0_42
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DOI: https://doi.org/10.1007/978-94-009-2637-0_42
Publisher Name: Springer, Dordrecht
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