Abstract
The application of the 1H-NMR spectroscopy for the prove of the cyclodextrin inclusion formation in solution can be shown for different drug cyclodextrin systems. Alterations can be seen in the cyclodextrin spectra as well as in the drug spectra. In the case of cyclodextrin/Solutol HS15 and Menadione Sodium Bisulfite systems the signals of the protons located in the cyclodextrin cavity show characteristic alterations. In the Vitamin A Acetate/Dimethyl-β-cyclodextrin and Menadion Sodium Bisulfite/γ-cyclodextrin systems signal splits and shifts of drug protons can be observed in the spectra.
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© 1988 Kluwer Academic Publishers
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Norwig, J., Gelder, T., Kraus, C., Mehnert, W., Rehse, K., Frömming, KH. (1988). Some Interesting Aspects in 1H-NMR Spectroscopy by Cyclodextrin Complexation. In: Huber, O., Szejtli, J. (eds) Proceedings of the Fourth International Symposium on Cyclodextrins. Advances in Inclusion Science, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2637-0_31
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DOI: https://doi.org/10.1007/978-94-009-2637-0_31
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7690-6
Online ISBN: 978-94-009-2637-0
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