Abstract
Cyclodextrins have been shown to act as second sphere molecular receptors for transition metal complexes bearing hydrophobic ligands. The majority of work has concentrated on ferrocene and its derivatives but other substrates such as chromium arene complexes, allyl palladium complexes, transition metal diene complexes, and the antitumour drug carboplatin, provide adducts of greater variety. Crown ethers also act as second sphere ligands for transition metal complexes bearing ligands with acidic hydrogen atoms, notably ammine ligands. A macrobicyclic polyether has been designed, synthesised and demonstrated to act as an effective molecular receptor for transition metal cis-diammines. On the basis of these observations, a ditopic receptor was designed for carboplatin and the synthesis of this ‘molecular oyster’ and other chemically-modified cyclodextrins, used as intermediates for its preparation, is described.
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© 1988 Kluwer Academic Publishers
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Stoddart, J.F., Zarzycki, R. (1988). Chemically-Modified Cyclodextrins as Second Sphere Ligands for Transition Metal Complexes. In: Huber, O., Szejtli, J. (eds) Proceedings of the Fourth International Symposium on Cyclodextrins. Advances in Inclusion Science, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2637-0_30
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DOI: https://doi.org/10.1007/978-94-009-2637-0_30
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