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Role of metallothionein in copper and zinc metabolism: special reference to inflammatory conditions

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Copper and Zinc in Inflammation

Part of the book series: Inflammation and Drug Therapy Series ((IDTH,volume 4))

Abstract

There is an increasing body of evidence which suggests that in mammals copper and zinc metabolism is subject to hormonal regulation. The specific hormones involved include those that control key pathways of intermediary metabolism, e.g. glucocorticoids, glucagon, insulin and catecholamines. Furthermore, hormonal factors associated with the host defence system, e.g. in-terleukin-1, have similar regulatory effects. A significant factor in the regulation of these metabolic effects is directly related to control of metallothionein gene expression. In this brief review we will describe aspects of the metabolism of both trace elements as related to metallothionein as a functional entity, and how this is influenced by inflammatory conditions.

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Author information

Authors and Affiliations

  1. Food Science and Human Nutrition Department and Centre for Nutritional Sciences, University of Florida, Gainesville, Florida, USA

    A. Grider Jr & R. J. Cousins

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  1. A. Grider Jr
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  2. R. J. Cousins
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Editors and Affiliations

  1. Institute of Pharmacology, University of Verona, Italy

    R. Milanino  & G. P. Velo  & 

  2. Department of Biomedical Sciences, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada

    K. D. Rainsford

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© 1989 Kluwer Academic Publishers

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Grider, A., Cousins, R.J. (1989). Role of metallothionein in copper and zinc metabolism: special reference to inflammatory conditions. In: Milanino, R., Rainsford, K.D., Velo, G.P. (eds) Copper and Zinc in Inflammation. Inflammation and Drug Therapy Series, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2619-6_3

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  • DOI: https://doi.org/10.1007/978-94-009-2619-6_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7682-1

  • Online ISBN: 978-94-009-2619-6

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