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Observations of Primary and Secondary Lesions in the Same Patient

  • Chapter
Etiology of Cancer in Man

Part of the book series: Cancer Growth and Progression ((CAGP,volume 6))

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Abstract

Invasive neoplastic growth can lead to cancer metastasis, and cancer mortality is most often related to cancer metastasis rather than the primary lesion (16). In an effort to learn more about human cancer metastasis, a number of animal tumor models have been developed in the last several years in an attempt to critically examine parameters of primary versus metastatic cancer lesions. Some of these models have explored differences between primary tumors and metastatic cell lines derived from them which develop lesions preferentially in specific secondary organs, such as lungs (13), liver (8, 36, 39), brain (10) or ovaries (9). Metastatic variant cell lines have often been noted to differ from primary cell lines in several characteristics, such as antigenicity (4, 12, 21, 22, 23, 25, 33, 34, 36), resistance to killing by host cells (17, 27) and drug resistance (1, 32, 42).

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Authors
  1. Kenneth W. Brunson
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  2. Ronald H. Goldfarb
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Editor information

Editors and Affiliations

  1. National Institutes of Child Health & Human Development, National Institutes of Health, Bethesda, Md., USA

    Arthur S. Levine

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© 1989 Kluwer Academic Publishers, Dordrecht

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Brunson, K.W., Goldfarb, R.H. (1989). Observations of Primary and Secondary Lesions in the Same Patient. In: Levine, A.S. (eds) Etiology of Cancer in Man. Cancer Growth and Progression, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2532-8_23

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  • DOI: https://doi.org/10.1007/978-94-009-2532-8_23

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7644-9

  • Online ISBN: 978-94-009-2532-8

  • eBook Packages: Springer Book Archive

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