Abstract
Extensive studies (60) have established roles of prolactin and estrogen in mammary tumorigenesis (60). On the other hand, the participation of these two major hormones in human breast cancer is still far from conclusion, probably due to the restricted conditions of clinical research. Therefore more intensive comparative studies on experimental animals and humans are needed. From this viewpoint, the roles of prolactin and estrogen in mammary tumorigenesis and their significance in human breast cancer are briefly discussed.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Abdul-Haji YJ: Effect of catechol estrogens on rat mammary tumors. Cancer Res 39: 4882, 1979
Bergink EW: Oestriol receptor interaction: Their biological importance and therapeutic implications. Acta Endocrinol 233 (Suppl.):9, 1980
Bolander FE Jr, Topper YJ: Loss of defferentiative potential of the mammary gland in ovariectomized mice: Identification of a biochemical lesion. Endocrinology 108:1649, 1981
Calaf G, Martinez F, Russo IH, Russo J: Age-related variations in growth kinetics of primary human breast cell culture. IRCS Med Sci 10:551, 1982
Calaf G, Martinez F, Russo IH, Roi LD, Russo J: The influence of age on DNA labeling index of human breast epithelium. IRCS Med Sci 10:657, 1982
Clifton KH, Furth J: Mammotropin effects in tumor induction and growth. In Hormonal Proteins and Peptides. Vol. VIII. Li, C.H. ed. pp. 75–103, New York, Academic Press, 1980
Coezy E, Rochefort H: Effect of pituitary isografts on the concentration of estrogen and glucocorticoid receptors in C3H mice mammary tumors. Europ J Cancer 15:1185, 1979
Cohen LA: Influence of chronic prolactin suppression during puberty on the development of dimethylbenz(a)anthracene-induced mammary tumors. Proc Soc Exp Biol Med 167:275, 1981
Dao TL: Inhibition of tumor induction in chemical carcinogenesis in the mammary glands. Progr Exp Tumor Res 14:59, 1971
Dao TL: The role of ovarian steroid hormones in mammary carcinogenesis. In Banbury Report 8, Hormone and Breast Cancer. Pike, M.C., Siiteri, P.K. & Welsch, C.W. eds. pp. 281–198, Cold Spring Harbor Lab, 1981
Del Pozo E, Darragh A, Lancranjan J, Ebeling D, Burmeister P, Bühler F, Marbach P, Braun P: Clin Endocrinol 6 (Suppl.):, 1977
Dilley WG, Kister SJ: In vitro stimulation of human breast tissue by human prolactin. J Natl Cancer Inst 55:35, 1975
Edery M, Goussard J, Vives C, Rudali G, Drosdowsky MA: Interactions between prolactin and ovarian secretions during mammary tumorigenesis in the mouse. Biomedicine 33:265, 1980
Furth J: The role of prolactin in mammary carcinogenesis. In: Human Prolactin. Pasteels, J.L. & Robyn, C. eds. pp. 233–248, New York, Excerpta Med, 1973
Hill P, Chan P, Cohen L, Wynder EL, Kuno K: Diet and endocrine related cancer. Cancer 39:1820, 1979
Hill PB, Wynder EL: Effect of a vegetarian diet and dexameth-asone on plasma prolactin, testosterone and dehydroepian-drosterone in men and women. Cancer Letter 7:273, 1979
MacMahon B, Cole P: Etiology of human breast cancer: A review. J Natl Cancer Inst 50:21, 1973
McManus MJ, Welsch CW: DNA synthesis of benign breast tumors in the untreated athymic “nude” mice. An in vivo model to study hormonal influence on growth of human breast tissues. Cancer 45:2160, 1980
McManus MJ, Dombroska SE, Pienkowski UM, Anderson TM, Mann LC, Schuster JS, Vollwiler LL, Welsch CW: Successful transplantation of human benign breast tumors into the athymic nude mouse and demonstration of enhanced DNA synthesis by human placental lactogen. Cancer Res 38:2324, 1978
Marklarkey WB, Kennedy M, Allred LE, Milo G: Physiological concentrations of prolactin can promote the growth of human breast tumor cells in culture. J Clin Endocrinol Metab 56:673, 1983
Manni A, Trujillo JE, Pearson OH: Predominant role of prolactin in stimulating the growth of 7,12-dimethyl-benz(a)anthracene-induced rat mammary tumor. Cancer Res 37:1216, 1977
Manni A, Rainieri J, Arffah BM, Pearson OH: Effect of high-dose oestrogen administration on the growth and prolactin receptor content of N-nitrosomethylurea-induced mammary tumors in the rat. J Endocr 93:11, 1982
Meites J: Relation of prolactin and estrogen to mammary tumorigenesis in rats. J Natl Cancer Inst 48:1217, 1972
Mietes J, Cassell E, Clark J: Estrogen inhibition of mammary tumor growth in rats. Counteraction by prolactin. Proc Soc Exp Biol Med 137:1225, 1971
Meites J, Lu KH, Wuttke W, Welsch CW, Nagasawa H, Quadri S: Recent studies on function and control of prolactin secretion in rats. Recent Progr Hormone Res 28:471, 1972
Meyer SJ: Cell proliferation in normal breast ducts, fibroadenomas and other ductal hyperplasias measured by nuclear labelling with tritiated thymidines. Human Pathol 8:67, 1977
Moon RC: Influence of pregnancy and lactation on experimental mammary carcinogenesis. In Banbury Report 8, Hormones and Breast Cancer. Pike, M.C., Siiteri, P.K. & Welsch, CW. eds. pp. 353–364, Cold Spring Harbor, Cold Spring Harbor Lab, 1981
Nagasawa H: Mammary gland DNA synthesis as a limiting factor for mammary tumorigenesis. IRCS Med Sci 5:405, 1977
Nagasawa H: Prolactin and human breast cancer: A review. Europ J Cancer 15:267, 1979
Nagasawa H: Causes of age-dependency of mammary tumor induction by carcinogens in rats. Biomedicine 34:9, 1981
Nagasawa H: Human prolactin and normal and abnormal breast tissue. In Hormones and Normal and Abnormal Human Tissues. Fotherby K. & Pal S.B. eds. pp. 115–143, Berlin, Walter de Gruyter 1981
Nagasawa H: Hormones and experimental mammary tumorigenesis. In Hormone Related Tumors, Nagasawa H. & Abe K. eds. pp. 137–163, Tokyo/Berlin, Jap Sci Soc Press/Springer-Verlag, 1981
Nagasawa H: Role of prolactin and placental lactogen in mammary tumor development in experimental animals. In Hormonal Regulation of Mammary Tumors. Vol. 2, Leung B.S. ed. pp. 1–24, Montreal, Raven Press, 1982
Nagasawa H: Prolactin as a promoter of initial progression of spontaneous mammary tumors in mice and lack of relationship to age. Life Sci 1983
Nagasawa H: Role of prolactin in the development of experimental mammary tumors. Excerpta Med Int Congr Ser No 598, pp. 459–464, 1983
Nagasawa H: Prolactin and mammaty gland physiology; A review. Univ. Sheffield Biomed. Inf Ser (Suppl 1): 1–59, 1983
Nagasawa H, Morii, S: Prophylaxis of spontaneous mammary tumorigenesis by temporal inhibition of prolactin secretion in rats at young ages. Cancer Res 41:1935, 1981
Nagasawa H, Morii, S: Inhibition by early treatment with bromocriptine of spontaneous mammary development in rats with no side-effects. Acta Endocrinol 101:51, 1982
Nagasawa H, Sakai, S, Banerjee, MR: Prolactin receptor: A minireview. Life Sci 24:193, 1979
Nagasawa H, Sakai, S., Banerjee, MR: Significance of prolactin receptor in mammary tumorigenesis. In Endocrinology of Cancer Vol III, Rose, DP. ed. pp. 77–92, Boca Raton, CRC Press, 1982
Nagasawa H, Vorherr, H: Rat mammary desoxyribo-nucleic acid synthesis during the estrous cycle, pregnancy and lactation to mammary tumorigenesis. Its implication for human breast cancer. Amer J Obstet Gynecol 127:590, 1977
Nagasawa H, Yanai, R: Effects of prolactin or growth hormone on growth of carcinogen-induced mammary tumors of adreno-ovariectomized rats. Int J Cancer 6:488, 1970
Nagasawa H, Yanai, R: Increased mammary gland response to pituitary mammotropic hormones by estrogen in rats. Endocrinol Japon 18:53, 1971
Nagasawa H, Yanai, R: Reduction by pituitary isografts of inhibitory effect of large doses of estrogen on induction of mammary tumors induced by carcinogen in ovariectomized rat. Int J Cancer 8:463, 1971
Nagasawa H, Yanai, R: Inhibitory effect of estrogen on mammary growth and its counteraction by pituitary isograft in mice. Endorcinol Japon 19:107, 1972
Nagasawa H, Yanai, R: Effects of estrogen and/or pituitary graft on nucleic acid synthesis of carcinogen-induced mammary tumors in rats. J Natl Cancer Inst 52:1219, 1974
Nagasawa H, Yanai, R: Mammary nucleic acid and pituitary prolactin secretion during prolonged lactation in mice. J Endocr 70:389, 1976
Nagasawa H, Yanai, R: Effects of oestrogen and/or pituitary grafts on nucleic acid synthesis in the mammary glands of lactating mice. J Endocr 77:319, 1978
Nagasawa H, Yanai, R: Normal and abnormal growth of mammary gland. In Physiology of Mammary Glands. Yokoyama, A, Mizuno, H. Nagasawa, H. eds. pp. 121–159. Tokyo/ Baltimore, Jap Sci Soc Press/Univ Park Press, 1978
Nagasawa H, Yanai R, Taniguchi H: Importance of mammary gland DNA synthesis on carcinogen-induced mammary tumorigenesis in rats. Cancer Res 36:2223, 1976
Russo J, Russo IH: Is differentiation the answer in breast cancer prevention? IRCS Med Sci 10:935, 1982
Russo J, Tay LK, Russo IH: Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res Treat 2:5, 1982
Sterental A, Dominguez JM, Weissman C, Pearson OH: Pituitary role in the estrogen dependency of experimental mammary cancer. Cancer Res 23:481, 1963
Throner MO, Besser GM, Jones A, Dacie J, Jones AE: Bromocriptine treatment of female infertility: Report of 13 pregnancies. Br Med J 4:694, 1975
Tokunaga M, Norman JE, Asano M, et al: Malignant breast tumors among atomic bomb survivors Hiroshima and Nagasaki. J Natl Cancer Inst 65:353, 1980.
Vorherr H: The Breast. Morphology, Physiology and Lactation. New York, Academic Press, 1974
Vorherr H: Breast Cancer. Epidemiology, Endocrinology, Biochemistry and Pharmacology. New York, Academic Press, 1980
Vorherr H: Hormone and prostaglandins in relation to cancer. In Hormone Related Tumors. Nagasawa H. & Abe K. eds. pp. 165–198, Tokyo/Berlin, Jap Sci Soc Press/Springer-Verlag, 1981
Welsch CW: Prolactin and growth hormone in the development, progresson, and growth of murine mammary tumors. In Bunbury Report 8, Hormones and Breast Cancer. Pike MC. Siiteri PK. Welsch CW. eds. pp. 299–355, Cold Spring Harbor, Cold Spring Harbor Lab, 1981
Welsch CW: Hormones and murine mammary tumorigenesis: An historical view. In Hormonal Regulation of Mammary Tumors. Vol. I. Leung BS. ed. pp. 1–29, Raven Press, Montreal, 1982
Welsch CW, McManus MJ: Stimulation of DNA synthesis by human placental lactogen or insulin in organ cultures of benign human breast tissue. Cancer Res 37: 2257, 1977
Welsch CW, Morford LK: Influence of chronic treatment with 2-bromo-α-egocriptine (CB-154) on the reproduction and lactational performance of the C3H/He female mouse. Ex-perimentia 30:1353, 1974
Welsch CW, Nagasawa H: Prolactin and murine mammary tumorigenesis: A review. Cancer Res 37:951, 1977
Welsch CW, Rivera EM: Differential effects of estrogen and prolactin in DNA synthesis in organ cultures of DMBA-induced rat mammary carcinoma. Proc Soc Exp Biol Med 139:623, 1972
Yanai R, Nagasawa H: Oestrogenic effects of catechol oes-trogens on secretion of prolactin by the pituitary gland and synthesis of DNA by the mammary gland in ovariectomized rats. J Endocr 82:131, 1979
Yanai R, Nagasawa H: Comparative study on the effects of estradiol and estriol on pituitary prolactin secretion and mammary gland DNA synthesis of rats in relation to their role in mammary tumorigenesis. Europ J Cancer 16:339, 1980
Zumoff B: The role of endogenous estrogen excess in human breast cancer. Anticancer Res 1: 39, 1981
Postsript References
Brodie AM, Santen RJ: Aromatase in breast cancer and the role of aminoglutethimide and other aromatase inhibitors. CRC Crit Rev Oncol Hematol 5(4):361, 1986
Dickson RB, Lippman ME: Estrogenic regulation of growth and polypeptide growth factor secretion in human breast carcinoma. Endocr Rev 8(1):29, 1987
Kaye AM, Hallowes R, Cox S, Sluyser M: Hormone-responsive creatine kinase in normal and neoplastic mammary glands. Ann NY Acad Sci 464:218, 1986
Lippman ME, Dickson RB, Gelmann EP, et al.: Growth regulation of human breast carcinoma occurs through regulated growth factor secretion. J Cell Biochem 35(1): 1, 1987
Matsuzawa A: Hormone dependence and independence of mammary tumors in mice. Int Rev Cytol 103:303, 1986
Matsuzawa A: The role of hormones in neoplastic transformation. Nipponn Rinsho 44(2):289, 1986
Matsuzawa A, Hayakawa T, Takitani S, Iwaguchi T: Comparative studies on estrogen receptors between a pregnancy-dependent mouse mammary tumor (TPDMT-4) and related autonomous tumors. Endocrinology 120(6):2346, 1987
Nagasawa H, Ohta K, Nakajima, K, et al.: Interrelationship between pituitary and ovarian hormones in normal and neoplastic growth of mammary glands of mice Ann NY Acad Sci 464:301, 1986
Noguchi S, Nishizawa Y, Nakamura N, et al.: Growth-stimulating effect of pharmacological doses of estrogen on androgen-dependent Shionagi carcinoma 115 in vivo but not in cell culture. Cancer Res 47(1):263, 1987
Paridaens RJ: Characterization and therapeutic use of hormone dependency of breast cancer. Acta Clin Belg 43(2): 127, 1988
Parker MG, Webb P, Needham M, et al.: Identification of androgen response elements in mouse mammary tumour virus and the rat prostate C3 gene. J Cell Biochem 35(4):285, 1987
Russo J, Russo IH: Biological and molecular bases of mammary carcinogenesis. Lab Invest 57(2): 112, 1987
Schneider MR: Acetoxy sibstotited 1.1.2-triphenylbut-1-enes: estrogenic, antiestrogenic and mammary tumor inhibiting activity. J Cancer Res Clin Oncol 112(2).T19, 1986
Schneider MR: 2-alkyl-substituted 1,1-bis(4-acetoxyphenyl)-2-phenylethenes. Estrogen receptor affinity, estrogenic and antiestrogenic properties, and mammary tumor inhibiting activity. J Med Chem 29(8): 1494, 1986
Welsch CW: Interrelationship between dietary fat and endocrine processes in mammary gland tumorigenesis. Prog Clin Biol Res 222:623, 1986
Yokoro K, et al.: Carcinogenic and co-carcinogenic effects of radiation in rat mammary carcinogenesis and mouse T-cell lymphomagenesis: a review. Int J Radiat Biol 51(6): 1069, 1987
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Kluwer Academic Publishers, Dordrecht
About this chapter
Cite this chapter
Nagasawa, H. (1989). Prolactin and Estrogen in Mammary Tumorigenesis. In: Levine, A.S. (eds) Etiology of Cancer in Man. Cancer Growth and Progression, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2532-8_10
Download citation
DOI: https://doi.org/10.1007/978-94-009-2532-8_10
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7644-9
Online ISBN: 978-94-009-2532-8
eBook Packages: Springer Book Archive