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Immunosuppression by Metastatic Tumors

  • Chapter
Influence of the Host on Tumor Development

Part of the book series: Cancer Growth and Progression ((CAGP,volume 4))

Abstract

The role of the immune response in preventing or limiting tumor growth as well as affecting the outcome of tumor metastases has long been debated among cancer biologists. A general consensus has emerged which depicts the major components of the immune system which are involved in immune surveillance and immunologic mechanisms of tumor cell killing to be cell-mediated: T-cell mediated cytotoxicity, macrophage mediated cytotoxicity (including antibody-dependent cell-mediated cytotoxicity, or ADCC, which may involve the macrophage as well as certain other cell populations) and natural killer (NK) cell cytotoxicity of tumor cells (2, 4, 6, 29). All too obviously, these mechanisms are not always completely effective in controlling the development, progressive outgrowth and metastasis of tumor cells. Cancer cells may circumvent control by the immune system in various ‘escape’ mechanisms, such as antigenic modulation, growth in immunologically ‘privileged’ sites, production of excess antigen or antigen-antibody complexes (including ‘blocking factors’), or immunosuppression.

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Authors
  1. Kenneth W. Brunson
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  2. Ronald H. Goldfarb
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Editors and Affiliations

  1. Pittsburgh Cancer Institute, Pittsburgh, Pa., USA

    Ronald B. Herberman

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© 1989 Kluwer Academic Publishers, Dordrecht

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Brunson, K.W., Goldfarb, R.H. (1989). Immunosuppression by Metastatic Tumors. In: Herberman, R.B. (eds) Influence of the Host on Tumor Development. Cancer Growth and Progression, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2530-4_18

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  • DOI: https://doi.org/10.1007/978-94-009-2530-4_18

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7643-2

  • Online ISBN: 978-94-009-2530-4

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