Abstract
That tumors are capable of synthesizing particular hormones or hormone subunits not normally produced by the specific tissue of origin of the tumor has been known since Brown described the diabetes of a bearded woman in Lancet in 1928 (13). However, even though in the autopsy of this obese, diabetic, hirsute and hypertensive patient the presence of bilateral adrenal hyperplasia and oat cell carcinoma of the lung were observed, the clinical syndrome was not correlated with the presence of the tumor. Only did in 1932 Harvey Cushing (18) describe the clinical syndrome, caused by the secretions of adenomatous or hyperplastic pituitary basophil cells stimulating bilateral adrenocortical hyperplasia (43). The characterization of cortisol, and human adrenocorticotropin (ACTH) led to realization that the pituitary is the site of the primary disorder in bilateral adrenal hyperplasia, thus defining ‘Cushing’s disease’, whereas ‘Cushing’s syndrome’ was reserved for the clinical entity caused by extra-hypophyseal secretion of ACTH.
This work was supported by Grant CA-22453 from the National Cancer Institute, DHHS, to the Comprehensive Cancer Center of Metropolitan Detroit and an Institutional Grant from the United Foundation of Greater Detroit.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Acevedo HF, Slifkin M, Pouchet GR, Rakhsham M: Identification of the B-Subunit of Choriogonadotropin in Human Spermatozoa. In The Testis in Normal and Infertile Men, edited by Troen P, Nankin HR. Raven Press, New York, p. 185, 1977
Asa SL, Kovacs K, Tindall GT, Barrow DL, Horvath E, Vecsei P: Cushing’s Disease Associated with an Intrasellar Gangliocytoma Producing Corticotropin-Releasing Factor. Ann Int Med 101:789, 1984
Atkinson PR, Weidman ER, Bhaumick B, Bala RM: Release of Somatomedin-like activity by cultured WI-38 human fibroblasts. Endocrinology 106:2006, 1980
Betsholtz C, Heldin C, Nister M, Ek B, Wateson A, Westmark B: Synthesis of a PDGF-Like Growth Factor in Human Glioma and Sarcoma Cells Suggests the Expression of the Cellular Homologue to the Transforming Protein of Simian Sarcoma Virus. Biochem Biophys Res Commun 117:176, 1983
Bewsher PD: Ectopic Hormone Production by Tumours. Clinical Aspects Scott Med J 25:142, 1980
Bhattcharya SK, Sealy WC: Paraneoplastic Syndromes Resulting from Elaboration of Ectopic Hormones, Antigens and Bizarre Toxins. In Current Problems in Surgery. Chicago: Year Book Medical Publishers, Inc. 1972
Black MM, Speer FD: Nuclear Structure in Cancer Tissues. Surg Gynecol Obstet 105:97, 1957
Blatt J, White C, Dienes S, Friedman H, Foley TP, Jr.: Production of an Insulin-like Growth Factor by Osteosarcoma. Biochem Biophys Res Com 123:373, 1984
Bloom HJG, Richardson WW: Histologic Grading and Prognosis in Breast Cancer: Study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer 11:359, 1957
Braunstein GD, Vaitukaitis JL, Carbonne PP, Ross GT: Ectopic Production of human Chorionic Gonadotropin by Neoplasms. Ann Int Med 78:39, 1973
Braunstein GD, Rasor J, Wade ME: Presence of an HCG-Like Substance in Non-Pregnant Humans. In Chorionic Gonadotropin edited by Segal SJ. Plenum Press, New York and London, p. 383, 1980
Brown H, Lane M: Cushing’s and Malignant Carcinoid Syndromes from Ovarian Neoplasm. Arch Intern Med 115:490, 1965
Brown WH: A Case of Pluriglandular Syndrome-Diabetes in a Bearded Woman. Lancet 2:1022, 1928
Canalis E, Peck WA, Raisz LG: Stimulation of DNA and Collagen Synthesis by Autologous Growth Factor in Cultured Fetal Rat Calvaria. Science 1021:1023, 1980
Carey RM, Orth DN, Hartmann WH: Malignant Melanoma with Ectopic Production of Adrenocorticotropic Hormone: Palliative Treatment with Inhibitors of Adrenal Steroid Biosynthesis. J Clin Endocrinol Metabol 36:482, 1973
Ciocca DR: Immunocytochemistry of an Estrogen-Regulated Protein (28K) in Estrogen Target Cells and Tissues. In: Immunocytochemistry in Tumor Diagnosis. Edited by Russo J. Boston, Martinus Nijhoff, Publishing, p. 268, 1985
Cohle SD, Tschen JA, Smith FE, Lane M, McGavran M: ACTH secreting Carcinoma of the Breast. Cancer 43:2370, 1979
Cushing H: The Basophil Adenomas of the Pituitary Body and their Clinical Manifestations (Pituitary Basophilism). Bull Johns Hopkins Hosp 50:137, 1932
De Larco JE, Todaro GJ: A Human Fibrosarcoma Cell Line Producing Multiplication Stimulating Activity (MSA) — Related Peptides. Nature, 272:356, 1978
Ellison ML: Cell Differentiation and the Biological Significance of Inappropriate Tumour Products. Proc R Soc Med 70:845, 1977
Feyrter F: Ueber Diffuse Endokrine Epitheliale Organe. Leipzig, Barth, 1938
Feyrter F: Zur Pathologie des argyrophilen Helle-Zellen Organes im Bronchialbaum des Menschen. Virchows Arch Pathol Anal 325:723, 1954
Foote FW, Jr.: Surgical Pathology of Cancer of the Breast. In Cancer of the Breast. Edited by Parsons WH. Springfield, IL, Charles C Thomas, p. 37, 1959
Furlaneto RW, Underwood LE, Van Wyk JJ, D’Ercole AJ: Estimation of Somatomedin-C Levels in Normals and Patients with Pituitary Disease by Radioimmunoassay. J Clin Invest 60:648, 1977
Gewirtz G, Yalow RS: Ectopic ACTH Production in Carcinoma of the Lung. J Clin Invest 53:1022, 1974
Gomi K, Kameya T, Tsumuraya M, Shimosanto Y, Zeze F, Abe K, Yoneyama T: Ultrastructural, Histochemical and Biochemical Studies of Two Cases with Amylase, ACTH and B-MSH Producing Tumor. Cancer 38:1645, 1976
Gould VE, Linnoila RI, Memoli VA, Warren WH: Neuroendocrine Cells and Neuroendocrine Neoplasms of the Lung. Pathol Annu edited by Sommers, SC and Rosen PP. Appleton-Century-Crofts/Norwalk, CT, p. 287, 1983
Heyderman E, Chapman DV, Richardson TC, Calvert I, Rosen SW: Human Chorionic Gonadotropin and Human Placental Lactogen in Extragonadal Tumors. An Immu-noperoxidase Study of Ten Non-Germ Cell Neoplasms. Cancer 56:2674, 1985
Hisa S, Morinaga S, Kobayshi Y, Ojima M, Chikaoka H, Sasano N: Intramedullary Spinal Cord Germinoma producing HCG and Precocious Puberty in a Boy. Cancer 55:2845, 1985
Hörne CHN, Reid IN, Milne GD: Prognostic Significance of Inappropriate Production of Pregnancy Proteins by Breast Cancer. Lancet II, 279, 1976
Ito H, Tahara E: Human Chorionic Gonadotropin in Human Gastric Carcinoma. Acta Pathol Jpn 33:287, 1983
Iwasaki H, Mitsui T, Kikuchi M, Imai T, Fukushima K: Neuroendocrine Carcinoma (Trabecular Carcinoma) of the Skin with Ectopic ACTH Production. Cancer 48:753, 1981
Johnson FD: Ectopic ACTH Syndrome in APUD Tumors. Oncology 39:358, 1982
Jones HW, Plymate S, Gluck FB, Miles PA, Greene JF: Small Cell Nonkeratinizing Carcinoma of the Cervix Associated with ACTH Production. Cancer 38:1629, 1976
Lee I, Franke WW, Goulde VE: Immunohistochemistry of Neuroendocrine Neoplasms of the Bronchopulmonary Tract and Skin. In: Immunocytochemistry in Tumor Diagnosis. Edited by Russo J. Boston, Martinus Nijhoff Publishing, p. 174, 1985
Lieblich JM, Weintraub BD, Krauth GH, Kohler PO, Rabson AS, Rosen SW: Ectopic and Eutopic Secretion of Chorionic Gonadotropin and its Subunits In Vitro: Comparison of Clonal Strains from Carcinomas of Lung and Placenta. J Natl Cancer Inst 56:911, 1976
Monteiro JCMP, Ferguson KM, McKinna JA, Greening WP, Neville AM: Ectopic Production of Human Chorionic Go-nadotropin-Like Material. Breast Cancer 53:957, 1984
Morales AR, Gould EW, Nadji M: Immunochemistry of Soft Tissue Tumors. In: Immunocytochemistry in Tumor Diagnosis. Edited by Russo J. Boston, Martinus Nijhoff, p. 362, 1985
Nichols J, Warren JC, Mantz FA: ACTH-like Excretion from Carcinoma of the Ovary. JAMA 182:713, 1962
Odell WD, Wolfsen A, Yoshimoto Y, Weitzman R, Fisher D, Hirose F: Ectopic Peptide Synthesis. A Universal Concomitant of Neoplasia. Trans Assoc Amer Phys 90:204, 1977
Odell WD, Wolfsen IR, Bachelot I, Hirose FM: Ectopic Production of Lipotropin by Cancer. Am J Med 66:631, 1979
Odell WD, Saito E: Protein Hormone-Like Materials from Normal and Cancer Cells — ‘Ectopic’ Hormone Production. In 13th International Cancer Congress, Part E. Cancer Management, New York, Alan R. Liss, Inc. p. 247, 1983
Orth DN: The Old and the New in Cushing’s Syndrome. N Engl J Med 310:649, 1984
Parsons V, Rigby B: Cushing’s Syndrome Associated with Adenocarcinoma of the Ovary. Lancet 2:992, 1958
Pearse AGE: The Cytochemistry and Ultrastructure of Polypeptide Hormone-Producing Cells of the APUD Series and the Embryologie, Physiologic and Pathologic Implications of the Concept. J Histochem Cytochem 17:303, 1969
Pearse AGE: The APUD Cell Concept and its Implications in Pathology. Pathol Ann 9:27, 1974
Pearse AGE, Polak JM, Heath CM: Polypeptide Hormone Production by ‘Carcinoid’ Apudomas and their Relevant Cytochemistry. Vir chows Arch B Cell Pathol 16:95, 1974
Pictet RL, Ralls LB, Phelps P, Rutter WJ: The Neural Crest and the Origin of the Insulin Producing and Other Gastrointestinal Hormone Producing Cells. Science 191:191, 1976
Pullan PT, Clement-Jones V, Corder R, Lowry PJ, Rees GM, Rees LH, Besser GM, Macedo MM, Galvao-Teles A: Ectopic Production of Methionine Enkephalin and Beta-endorphin. Br Med J i.758, 1980
Rees LH: The Biosynthesis of Hormones by Non-Endocrine Tumors — A Review. J Endocrinol 67:143, 1975
Rochefort H, Capony F, Cavalie-Barthez G, Chambon M, Garcia M, Massot O, Morisset M, Touitou I, Vignon F, Westley B: Oestrogen Induced Proteins Secreted by Breast Cancer. In: Biennial Intl Breast Cancer Res Conf, p. 25, 1985
Rost FWD, Polak JM, Pearse AGE: The Melanocyte: Its Cytochemical and Immunological Relationship to Cells of the Endocrine Polypeptide (APUD) series. Virchows Arch B Cell Pathol 4:93, 1969
Russo J: Immunocytochemical Markers in Breast Cancer. In: Immunocytochemistry in Tumor Diagnosis. Edited by Russo J. Boston, Martinus Nijhoff, p. 207, 1985
Russo IH: Organization of an Immunocytochemistry Laboratory. Ibid, p. 1, 1985
Sesterhenn I, Mostofi FK, Davis CJ, Jr.: Immunopathology of Prostate and Bladder Tumors. Ibid, p. 337, 1985
Shields R: Gene Derepression in Tumors. Nature 269:752, 1977
Shields R: Ectopic Hormone Production by Tumors. Nature 272:494, 1978
Sternberger LA, Sternberger NH: Principles of Immunocytochemistry. In: Immunocytochemistry in Tumor Diagnosis. Edited by Russo J. Boston, Martinus Nijhoff Publishing, p. 12, 1985
Szijj I, Csapo Z, Laszlo FA, Kovacs K: Medullary Cancer of the Thyroid Gland Associated with Hypercorticism. Cancer 24:167, 1969
Tambourin P, Casdevall N, Choppin J, Lacombe C, Heard JM, Fichelson S, Wendling F, Varet B: Production of Erythro-poietin-Like Activity by a Murine Erythroleukemia Cell Line. Proc Natl Acad Sci USA 80:6269, 1983
Toker C: Trabecular Carcinoma of the Skin. Arch Dermatol 105:107, 1972
Tormey DC, Waalken TP: Biochemical Markers in Cancer of the Breast. Recent Results Cancer Res 57:78, 1976
Tormey DC, Waalken TP, Simon RM: Biological Markers in Breast Carcinoma II. Clinical Correlations with Human Chorionic Gonadotropin. Cancer 39:2391, 1977
Tsukada T, Nakai Y, Jingami H, Imura H, Taii S, Nakanishi S, Numa S: Identification of the mRNA Coding for the ACTH-Lipotropin Precursor in a Human Ectopic ACTH-Producing Tumor. Biochem Biophys Res Com 98:535, 1981
Van Wyk JJ, Russell WE, Li CH: Synthetic Somatomedin C: Comparison with Natural Hormone Isolated from Human Plasma. Proc Natl Acad Sci USA 81:740, 1984
Van Zoelen EJJ, Twardzik DR, Van Oostwaard TMJ, Van Der Saag PT, Laat SW, Todaro GJ: Neuroblastoma Cells Produce Transforming Growth Factors During Exponential Growth in a Defined Hormone-Free Medium. Proc Natl Acad Sci USA 81:4085, 1984
Vuitch MF, Mendelsohn G: Relationship of Ectopic ACTH Production to Tumor Differentiation: A Morphologic and Immunohistochemical Study of Prostatic Carcinoma with Cushing’s Syndrome. Cancer 47:296, 1981
Woodard BH, Eisenbarth G, Wallace NR, Mossier JA, McCarty KS: Adrenocorticotropin Production by a Mammary Carcinoma. Cancer 47:1823, 1981
Wurz H: Serum Concentrations of SP1 (Pregnancy Specific B-Glycoprotein) in Healthy, Nonpregnant Individuals and in Patients with Nontrophoblastic Malignant Neoplasm. Arch Gynecol 227:1, 1979
Yamanouchi T, Akanuma Y, Tsushima T, Shizume K, Mizo-guchi H, Takaku F: New Powerful insulin-like protein from human promyelocytic leukemia cells. Endocrinology 114:1352, 1984
Yoshimoto Y, Wolfsen A, Odell WD: Human Chorionic Gonadotropin-like substances in Non-Endocrine Tissues of Normal Subjects. Science 197:575, 1977
Yoshimoto Y, Wolfsen A, Hirose F, Odell WA: Human Chorionic Gonadotropin-Like Material: Presence in Normal Human Tissue. Am J Obstet Gynecol 134:729, 1979
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Kluwer Academic Publishers, Dordrecht
About this chapter
Cite this chapter
Russo, I.H., Russo, J. (1989). Hormone Production by Tumors: Ectopia or Gene Derepression. In: Herberman, R.B. (eds) Influence of the Host on Tumor Development. Cancer Growth and Progression, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2530-4_17
Download citation
DOI: https://doi.org/10.1007/978-94-009-2530-4_17
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7643-2
Online ISBN: 978-94-009-2530-4
eBook Packages: Springer Book Archive