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Hormone Production by Tumors: Ectopia or Gene Derepression

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Influence of the Host on Tumor Development

Part of the book series: Cancer Growth and Progression ((CAGP,volume 4))

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Abstract

That tumors are capable of synthesizing particular hormones or hormone subunits not normally produced by the specific tissue of origin of the tumor has been known since Brown described the diabetes of a bearded woman in Lancet in 1928 (13). However, even though in the autopsy of this obese, diabetic, hirsute and hypertensive patient the presence of bilateral adrenal hyperplasia and oat cell carcinoma of the lung were observed, the clinical syndrome was not correlated with the presence of the tumor. Only did in 1932 Harvey Cushing (18) describe the clinical syndrome, caused by the secretions of adenomatous or hyperplastic pituitary basophil cells stimulating bilateral adrenocortical hyperplasia (43). The characterization of cortisol, and human adrenocorticotropin (ACTH) led to realization that the pituitary is the site of the primary disorder in bilateral adrenal hyperplasia, thus defining ‘Cushing’s disease’, whereas ‘Cushing’s syndrome’ was reserved for the clinical entity caused by extra-hypophyseal secretion of ACTH.

This work was supported by Grant CA-22453 from the National Cancer Institute, DHHS, to the Comprehensive Cancer Center of Metropolitan Detroit and an Institutional Grant from the United Foundation of Greater Detroit.

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Authors
  1. Irma H. Russo
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  2. Jose Russo
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  1. Pittsburgh Cancer Institute, Pittsburgh, Pa., USA

    Ronald B. Herberman

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© 1989 Kluwer Academic Publishers, Dordrecht

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Russo, I.H., Russo, J. (1989). Hormone Production by Tumors: Ectopia or Gene Derepression. In: Herberman, R.B. (eds) Influence of the Host on Tumor Development. Cancer Growth and Progression, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2530-4_17

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  • DOI: https://doi.org/10.1007/978-94-009-2530-4_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7643-2

  • Online ISBN: 978-94-009-2530-4

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