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DNA Transfection, Genetic Instability, and Metastasis

  • Chapter
Influence of Tumor Development on the Host

Part of the book series: Cancer Growth and Progression ((CAGP,volume 3))

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Abstract

DNA transfection offers a powerful tool for the investigation of genes that contribute to a variety of phenotypes. Transfer of DNA and detection of altered function, with the ultimate aim of gene identification and molecular cloning, has enhanced our knowledge of a variety of loci, including oncogenes [see (53), (9) for reviews]. This technique is only now beginning to be applied to the complex process of tumor metastasis. In this chapter, I will discuss initial experiments, from my own laboratory and from other groups, in which techniques of DNA transfection have been applied to various aspects of tumor metastasis. I will also discuss specific features of both metastatic cells and DNA transfer procedures that must be taken into account in this sort of genetic analysis.

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Authors
  1. Ann F. Chambers
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Editors and Affiliations

  1. Department of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Md., USA

    Lance A. Liotta

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© 1989 Kluwer Academic Publishers, Dordrecht

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Chambers, A.F. (1989). DNA Transfection, Genetic Instability, and Metastasis. In: Liotta, L.A. (eds) Influence of Tumor Development on the Host. Cancer Growth and Progression, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2528-1_10

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  • DOI: https://doi.org/10.1007/978-94-009-2528-1_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7642-5

  • Online ISBN: 978-94-009-2528-1

  • eBook Packages: Springer Book Archive

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