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Chemoprevention Research

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Mechanisms of Carcinogenesis

Part of the book series: Cancer Growth and Progression ((CAGP,volume 2))

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Abstract

Early detection of precancerous and cancerous lesions and the elimination of carcinogenic agents dominated the field of cancer prevention until recently. However, an increased understanding of the carcinogenic process today may allow other ways to intervene in cancer development. It is known that the development of cancer in man often involves a long “silent” period before cancer can be clinically detected. Experimental carcinogenesis studies have furnished insights into the biochemical mechanisms and biological processes for defining the concepts of “initiation” and “promotion” in the genesis of cancer. Interfering with the process of carcinogenesis is becoming a more promising approach to cancer prevention.

Chemoprevention refers to the administration of chemical agents to prevent the sequence of events that follows the exposure of an individual to a carcinogenic agent and results in the development of a malignancy. It involves the introduction of selected micronutrients, both synthetic and naturally occurring, or other small molecular weight substances into the diet for the purposes of reducing cancer incidence.

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  1. Winfred F. Malone
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Editors and Affiliations

  1. National Cancer Institute, National Institutes of Health, Bethesda, Md., USA

    Elizabeth K. Weisburger

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© 1989 Kluwer Academic Publishers, Dordrecht

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Malone, W.F. (1989). Chemoprevention Research. In: Weisburger, E.K. (eds) Mechanisms of Carcinogenesis. Cancer Growth and Progression, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2526-7_4

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  • DOI: https://doi.org/10.1007/978-94-009-2526-7_4

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