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Oncogene Products as Potential Therapeutic Targets for Control of Established Metastatic Disease

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Mechanisms of Carcinogenesis

Part of the book series: Cancer Growth and Progression ((CAGP,volume 2))

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Abstract

An explosive pace of research has developed in the last several years exploring the role of oncogenes and their products (see preceding Chapters, 10–14, this volume). The potential of elucidating the molecular mechanisms operative in neoplastic transformation has generated widespread excitement and research interest within the scientific community, particularly among cancer biologists. A large component of research performed in this area has been directed towards understanding the biochemical and molecular basis of the initiation and promotion of the transformed phenotype of cells that have undergone oncogenic transfection in cell culture (4, 26, 46, 47, 51, 89, 90). A variety of studies have also indicated that oncogenes and their products may also contribute to additional aspects of tumor progression (5, 46, 47, 62, 87). Most recently, a number of research groups have carried out investigations to ascertain whether oncogenes and their encoded gene products contribute to the progressive stages of malignant neoplastic growth resulting in tumor invasion in tumor invasion and metastatic spread (1, 6, 7, 19, 20, 21, 22, 49, 68, 80, 85).

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References

  1. Albino AP, Le Strange R, Oliff AI, Furth ME, Old LJ: (1984). Transforming ras genes from human melanoma: a manifestation or tumour heterogeneity? Nature 308:69–71.

    Article  PubMed  CAS  Google Scholar 

  2. Albini A, Iwamoto Y, Kleinman HK et al: (1987). A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res 47:3239–3245.

    PubMed  CAS  Google Scholar 

  3. Astrin SM, Rothberg PG: (1983). Oncogenes and Cancer. Cancer Investig 1:355–364.

    Article  CAS  Google Scholar 

  4. Balmain A: Transforming ras oncogenes and multistage carcinogenesis. (1985). Br J Cancer 51:1–7.

    Article  PubMed  CAS  Google Scholar 

  5. Becker FF: Tumor phenotype and susceptibility to progression as an expression of subpopulations of initiated murine cells. (1985). Cancer Res 45:786–773.

    Google Scholar 

  6. Bernstein SC, Weinberg RA: Expression of the metastatic phenotype in cells transfected with human metastatic tumor DNA. (1985). Proc Natl Acad sci (USA) 82:1726–1730.

    Article  CAS  Google Scholar 

  7. Bondy GP, Wilson S, Chambers AF: (1985). Experimental metastatic ability of H-ras-transformed NIH3T3 cells. Cancer Res 45:6005–6009.

    PubMed  CAS  Google Scholar 

  8. Bradley MO, Kraynak AR, Storer RD et al: (1986). Experimental metastasis in nude mice of NIH3T3 cells containing various ras genes. Proc Natl Acad sci (USA) 83:5277–5281.

    Article  CAS  Google Scholar 

  9. Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM: (1984). Amplication of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 224:1121–1124, 1984

    Google Scholar 

  10. Brunson KW, Goldfarb RH: (1988). Immunosuppression by metastatic tumors. In: HE, Kaiser (ed.). Cancer Growth and Progression

    Google Scholar 

  11. Brunson KW, and Nicolson, GL: (1978). Selection and biologic properties of malignant variants of a murine lymphosarcoma. J Natl Cancer Inst 61:1499–1503.

    PubMed  CAS  Google Scholar 

  12. Brunson KW, Nicolson GL: (1980). Experimental brain metastasis. In. L. Weiss, HA, Gilbert, JB, Posner (Eds.). Brain Metastasis. GK, Hall and Co., Boston, pp 50–65.

    Chapter  Google Scholar 

  13. Chambers AF, Wilson, S: (1985). Cells transformed with a ts viral src mutant are temperature sensitive for in vivo growth. Molec Cell Biol 5: 728–733.

    PubMed  CAS  Google Scholar 

  14. Collard JG, van Beek WP, Janssen JWG, Schijven JF: (1985). Transfection by human oncogenes: Concomitant induction of tumorigenicity and tumor-associated membrane alterations. Int J Cancer 35:207–214.

    Article  PubMed  CAS  Google Scholar 

  15. Collard JG, Schijven JF, Roos E: (1987). Invasive and metastatic potential induced by ras-transfection into mouse BW5147 T-lymphoma cells. Cancer Res 47:754–759.

    PubMed  CAS  Google Scholar 

  16. Cook, JL, Lewis AM: (1984). Differential NK cell and macrophage killing of hamster cells infected with nononcogenic or oncogenic adenovirus. Science 224:612–616.

    Article  PubMed  CAS  Google Scholar 

  17. Dotto GP, Parada LF, Weinberg RA: (1985). Specific growth response of ras-transformed embryo fibroblasts to tumor promoters. Nature 318:472–475.

    Article  PubMed  CAS  Google Scholar 

  18. Duesberg PH: (1985). Activated proto-onc genes: sufficient or necessary for cancer? Science 228:669–667.

    Article  PubMed  CAS  Google Scholar 

  19. Eccles SA, Marshall C, Vousden K, Purvies H: (1985). Enhanced metastatic capacity of mouse mammary carcinoma cells transfected with H-RAS. Brit J Cancer 51:586.

    Google Scholar 

  20. Egan SE, McClarty GA, Wright JA, Greenberg AH: (1986). H-RAS transcriptional activation and metastasis formation. J Cellular Biochem Suppl 10A, 51 (Abstract A134).

    Google Scholar 

  21. Eisenbach L, Feldman M: (1985). Genes and antigens controlling tumor metastases. In. Neth, Gallo, Greaves and Janka, Eds. Haematology and Blood Transfusion, Vol. 29. Modern Trends in Leukemia VI. Springer Verlag Berlin pp 499–507.

    Google Scholar 

  22. Erisman MD, Rothberg PG, Diehl RE, Morse CC, Spandorfer JM, Astrin SM: (1985). Deregulation of c-myc gene expression in human colon carcinoma is not accompanied by amplification or rearrangement of the gene. Molec Cell Biol 5:1969–1976.

    PubMed  CAS  Google Scholar 

  23. Fermisco JR, Clark R, Wong G, Arnheim N, Milley R, McCormick F: (1985). Transient reversion of ras oncogene-induced cell transformation by antibodies specific for amino acid 12 of ras protein. Nature 314:639–642.

    Article  Google Scholar 

  24. Gallick GE, Kurzrock R, Kloetzer WS, Arlinghaus RB, and Gutterman, JU: (1985). Expression of p21 ras in fresh primary and metastatic human colorectal tumors. Proc Natl Acad Sci (U.S.A.) 82: 1795–1799.

    Article  CAS  Google Scholar 

  25. Garbisa S, Pozzatti R, Muschel R, Saffiotti U, Ballin M, Goldfarb, RH, Khoury G, Liotta LA: (1987). Secretion of type IV collagenolytic protease and metastatic phenotype: Induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-Ela. Cancer Res 47:1523–1528.

    PubMed  CAS  Google Scholar 

  26. Glaichenhaus N, Mougneau E, Connan G, Rassoulzadegan M, Cuzin, F: (1985). Cooperation between multiple oncogenes in rodent embryo fibroblasts: An experimental model of tumor progression? Adv Cancer Res 45:291–305.

    Article  PubMed  CAS  Google Scholar 

  27. Goldfarb RH: (1986a). Proteolytic enzymes in tumor invasion and degradation of host extracellular matrices. In. KV. Honn, WE, Powers, BF Sloane, Eds. Mechanisms of Cancer Metastasis: Potential Therapeutic Implications. Martinus Nijhoff, Boston, pp 341–375.

    Google Scholar 

  28. Goldfarb RH: (1986b). Cell-Mediated Cytotoxic Reactions. Human Pathology 17:138–145

    Article  PubMed  CAS  Google Scholar 

  29. Goldfarb RH, Liotta LA: (1986). Proteolytic enzymes in cancer invasion and metastasis. Seminars in Thrombosis and Hemostasis. 12:294–307

    Article  PubMed  CAS  Google Scholar 

  30. Goldfarb RH, Quigley JP: (1978). Synergistic effect of tumor virus transformation and tumor promoter treatment on the production of plasminogen activator by chick embryo fibroblasts. Cancer Res 38:4601–4609

    PubMed  CAS  Google Scholar 

  31. Goldfarb RH, Quigley JP: (1980). Purification of plasminogen activator from Rous sarcoma virus transformed chick embryo fibroblasts treated with the tumor promoter phorbol 12-myristate-13-acetate. Biochem 19:5463–5471

    Article  CAS  Google Scholar 

  32. Goldfarb RH, Brunson KW: (1987). Overview of current understanding of tumor spread. In. HE, Kaiser, Ed. Cancer Growth and Progression, Vol. I, Martinus Nijhoff, Boston, In Press

    Google Scholar 

  33. Green AR, Wyke JA: (1985). Anti-Oncogenes. A subset of regulatory genes involved in carcinogenesis? The Lancet. August 31. 475–477

    Article  Google Scholar 

  34. Greenberg AH, Egan SE, Jaroli, L. et al: (1987). Natural killer cell regulation of implantation and early lung growth of H-ras-transformed 10T1/2 fibroblasts in mice. Cancer Res 47:4801–4805.

    PubMed  CAS  Google Scholar 

  35. Greenhalgh DA, Kinsella AR: (1985). C-Ha-ras not c-Ki-ras activation in three colon tumor cell lines. Carcinogen 6:1533–1535

    Article  CAS  Google Scholar 

  36. Greig RG, Koestler TP, Trainer DL, Corwin SP, Miles L, Kline T, Sweet R, Yokoyama S, Poste G: (1985b). Tumorigenic and metastatic properties of “normal” and ras-transfected NIH-3T3 cells. Proc Natl Acad sci (USA) 82:3698–3701

    Article  CAS  Google Scholar 

  37. Hand PH, Thor A, Wunderlich D, Muraro R, Caruso A, Schlom J: (1984). Monoclonal antibodies of predefined specificity detect activated ras gene expression in human mammary and colon carcinomas. Pros Natl Acad sci (USA) 81:5227–5231

    Article  CAS  Google Scholar 

  38. Hart IR: (1985). Molecular basis of tumor spread. Nature 315:275

    Article  Google Scholar 

  39. Heighway J, Hasleton PS (1986). C-Ki-ras amplification in human lung cancer. Br J Cancer 53:285–287

    Article  PubMed  CAS  Google Scholar 

  40. Heppner GH: (1986). Problems posed for cancer treatment by tumor cell heterogeneity. In. KV Honn, WE Powers, BF Sloane, Eds. Mechanisms of cancer Metastasis. Potential Therapeutic Implications. Martinus Nijhoff. Boston pp. 69–79

    Google Scholar 

  41. Hsiao W.-L. W, Gattoni-Celli S, Weinstein IB: (1984). Oncogene-induced transformation of C3H 10T1/2 cells is enhanced by tumor promotors. Science. 226:552–555

    Article  PubMed  CAS  Google Scholar 

  42. Johnson PW, Baubock C, Roder JC: (1985). Transfection of a rat cell line with the v-Ki-ras oncogene is associated with enhanced susceptibility to natural killer cell lysis. J Exp Med 162:1732–1737

    Article  PubMed  CAS  Google Scholar 

  43. Kasid A, Lippman ME, Papageorge AG, Lowy DR and Gelmann, EP: (1985). Transfection of v-ras H DNA into MCF-7 human breast cancer cells bypasses dependence on estrogen for tumorigenicity. Science 228:725–728

    Article  PubMed  CAS  Google Scholar 

  44. Kerr IB, Lee FD, Quintanilla M, Balmain A: (1985). Immunocytochemical demonstration of p21 ras family oncogene product in normal mucosa and in premalignant and malignant tumors of the colorectum. Br J Cancer 52:695–700

    Article  PubMed  CAS  Google Scholar 

  45. Kerr IB, Spandidos DA, Finlay IG, Lee FD, McArdle CS: (1986). The relation of ras family oncogene expression to conventional staging criteria and to clinical outcome in colorectal carcinoma. Br J Cancer 53:231–235

    Article  PubMed  CAS  Google Scholar 

  46. Klein G, Klein E: (1984). Oncogene activation and tumor progression. Carcinogenesis. 5:429–435

    Article  PubMed  CAS  Google Scholar 

  47. Klein G, Klein E: (1985). Evolution of tumours and the impact of molecular oncology. Nature 315:190–195

    Article  PubMed  CAS  Google Scholar 

  48. Kris RM, Avivi A, Bar-Eli M, Alon Y, Carmi P, Schlessinger J, Raz A: (1985). Expression of KI-RAS oncogene in tumor cell variants exhibiting different metastatic capabilities. Int J Cancer 35:227–230

    Article  PubMed  CAS  Google Scholar 

  49. Kung H-F, Smith MR, Bekesi E, Manne V, Stacey DW: (1986). Reversal of transformed phenotype by monoclonal antibodies against Ha-ras p21 proteins. Exper Cell Res 162:363–371

    Article  CAS  Google Scholar 

  50. Kurzrock R, Gallick GE, Gutterman JU: (1986). Differential expression of p21ras gene products among histological subtypes of fresh primary human lung tumors. Cancer Res 46:1530–1534

    PubMed  CAS  Google Scholar 

  51. Land H, Parada LF, Weinberg RA: (1983a). Cellular oncogenes and multistep carcinogenesis. Science 222:771–778

    Article  PubMed  CAS  Google Scholar 

  52. Land H, Parada LF, Weinberg RA: (1983b). Tumorigenic conversion of primary embryo fibroblasts require at least two cooperating oncogenes. Nature 304:596–602

    Article  PubMed  CAS  Google Scholar 

  53. Lanza LA, Wilson DJ, Ikerji B et al: (1987). Human oncogene-transfected tumor cells display differential susceptibility to lysis by LAK and natural killer cells. J Immunol 137:2716–2720.

    Google Scholar 

  54. Liotta LA: (1986a). Tumor invasion and metastasis-role of the extracellular matrix. Rhoads Memorial Award Lecture. Cancer Res 46:1–7

    Article  PubMed  CAS  Google Scholar 

  55. Liotta LA: (1986b). Molecular biology of metastases: A review of recent approaches. Eur J Cancer Clin Oncol 22:345–348

    Article  PubMed  CAS  Google Scholar 

  56. Liotta LA, Goldfarb RH, Brundage R, Siegal GP, Terranova V, Garbisa S: (1981). Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane. Cancer Res 41:4629–4636

    PubMed  CAS  Google Scholar 

  57. Little CD, Nau MM, Carney DN, Gazdar AF, Minna JD: (1983). Amplification and expression of the c-myc oncogene in human lung cancer cells. Nature 306:194–196

    Article  PubMed  CAS  Google Scholar 

  58. Mareel MM, Van Roy FM: (1986). Are oncogenes involved in invasion and metastasis? Anticancer Res 6:419–436

    PubMed  CAS  Google Scholar 

  59. Masui H, Kawamoto T, Sato JD, Wolf B, Sato G, Mendelsohn J: (1984). Inhibition of human tumor cells in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies. Cancer Res. 44:1002–1007

    PubMed  CAS  Google Scholar 

  60. Muschel RJ, Williams JE, Lowy DR, Liotta LA: (1985). Harvey ras induction of metastatic potential depends upon oncogene activation and the type of recipient cell. Amer J Pathol 121:1–8

    CAS  Google Scholar 

  61. Nau MM, Brooks BJ, Battey J, Sausville E, Gazdar AF, Kirsch IR, McBride OW, Bertness V, Hollis GF, Minna JD: (1986). L-myc, a new myc-related gene amplified and expressed human small cell lung cancer Nature 318:69–73

    Article  Google Scholar 

  62. Nicolson GL: (1984). Tumor progression, oncogenes and the evolution of metastatic phenotypic diversity. Clin Expl Metastasis. 2:85–105.

    Article  CAS  Google Scholar 

  63. Niman HL, Thompson AMH, Yu A, Markman MK, Willems JJ, Herwig KR, Habib NA, Wood CB, Houghten RA, Lerner RA: (1985). Anti-peptide antibodies detect oncogene-related proteins in urine. Froc Natl Acad sci (U.S.A) 82:7924–7928

    Article  CAS  Google Scholar 

  64. Nowell, PC: (1986). Perspectives in Cancer Research: Mechanisms of Tumor Progression. Cancer Res 46:2203–2207

    PubMed  CAS  Google Scholar 

  65. Ohuchi N, Thor A, Page DL, Hand PH, Halter SA, Schlom, J: (1986). Expression of the 21,000 molecular weight ras protein in a spectrum of benign and malignant human mammary tissues. Cancer Res 46:2511–2519

    PubMed  CAS  Google Scholar 

  66. Poste G: (1984). Hype, hope and honesty. Biotechnology. December, 1984:1096

    Google Scholar 

  67. Poste G: (1986). Pathogenesis of metastatic disease: Implications for current therapy and for the development of new therapeutic strategies. Cancer Treat Rep 70:183–199

    PubMed  CAS  Google Scholar 

  68. Pozzatti R, Muschel R, Williams J, Padmanabhan R, Howard B, Liotta L, Khoury G: (1986). Primary rat embryo cells transformed by one or two oncogenes show different metastatic potentials. Science 232:223–227

    Article  PubMed  CAS  Google Scholar 

  69. Rothberg PG, Spandorfer JM, Erisman MD, Staroscik RN, Sears HF, Petersen RO, Astrin SM (1985). Evidence that C-myc expression defines two genetically distinct forms of colorectal adenocarcinoma. Br J Cancer 52:629–632

    Article  PubMed  CAS  Google Scholar 

  70. Rotter V, Wolf D, Blick M, Nicolson GL: (1985). Expression of abl and other oncogenes is independent of metastatic potential in Abelson virus-transformed malignant murine large cell lymphoma. Clin Expl Metastasis 3: 77–86

    Article  CAS  Google Scholar 

  71. Sager R: (1985a). Genetic suppression of tumor formation. Adv. Cancer Res 44:43–68

    Article  PubMed  CAS  Google Scholar 

  72. Sager R, Craig RW: (1985b). Anti-oncogenes and the suppression of tumor formation. In: J Feramisco, B Ozanne, C Stiles, Eds Cancer Cells Volume 3. Growth Factors and Transformation. Cold Spring Harbor Laboratory Press, Cold Spring Harbor Laboratory, pp. 95–100

    Google Scholar 

  73. Sager R: (1986). Genetic suppression of tumor formation: A new frontier in cancer research. Cancer Res 46:1573–1580

    PubMed  CAS  Google Scholar 

  74. Samid D, Chang EH, Friedman RM: (1985). Development of transformed phenotype induced by a human ras oncogene is inhibited by interferon. Biochem Biophys Res Comm 126:509–516

    Article  PubMed  CAS  Google Scholar 

  75. Schirrmacher V: (1985). Cancer metastasis: Experimental approaches, theoretical concepts, and impacts for treatment strategies. Adv in Cancer Res 43:1–73

    Article  CAS  Google Scholar 

  76. Shimizu, K, Goldfarb M, Suard Y, Perucho, M, Li Y, Kamata T, Feramisco J, Stavenezer E, Fogh J, Wigler MH: (1983). Three human transforming genes are related to the viral ras oncogenes. Proc Natl Acad sci (USA) 80:2113–2116

    Google Scholar 

  77. Sistonen L, Keski-Oja J, Ulmanen I, Holtta E, Wikgren B-J, Alitalo K: (1987). Dose effects of transfected c-Ha-ras val 12 oncogene in transformed cell clones. Exp Cell Res 168(2):518–30

    Article  PubMed  CAS  Google Scholar 

  78. Taya Y, Hosogai K, Hirohashi S, Shimosato Y, Tsuchiya R, Tsuchida N, Fushimi M, Sekiyua T, Nishimura S: (1984). A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer. EMBO J 3:2943–2946

    PubMed  CAS  Google Scholar 

  79. Thor A, Hand PH, Wunderlich D, Caruso A, Muraro R, Schlom J: (1984). Monoclonal antibodies define different ras gene expression in malignant and benign colonic diseases. Nature 311:562–565.

    Article  PubMed  CAS  Google Scholar 

  80. Thorgeirsson UP, Turpeenniemi-Hujanen T, Williams JE, Westin EH, Heilman CA, Talmadge JE, Liotta LA: (1984). NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice. Molec Cell Biol 5:259–262

    Google Scholar 

  81. Thorgeirsson UP, Turpeenniemi-Hujanen T, Liotta LA: (1985). Cancer cells, components of basement membranes, and proteolytic enzymes. Int. Rev Expt Path 27:203–234

    CAS  Google Scholar 

  82. Thorgeirsson UP, Turpeenniemi-Hujanen T, Talmadge, JE, Liotta LA: (1986). In. Welch DR, Bhuyan DK, Liotta LA (eds). Cancer Metastasis. Experimental and clinical Strategies. (Prog, in Clin, and Biol. Res., Vol. 212) Alan R, Liss, New York. pp. 77–95

    Google Scholar 

  83. Valenzuela DM, Groffen J: (1986). Four human carcinoma cell lines with novel mutations in position 12 of c-K-ras oncogene. Nucl Acids Res 14:843–852

    Article  PubMed  CAS  Google Scholar 

  84. Viola MV, Fromowitz F, Oravez S, Deb S, Finkel G, Lundy J, Hand P, Thor A, Schlom J: (1986). Expression of ras oncogene p21 in prostate cancer. New Eng J Med 314–133–137

    Google Scholar 

  85. Vousden KH, Marshall CJ: (1984). Three different activated ras genes in mouse tumors; evidence for an oncogene activation during progression of a mouse lymphoma. EMBO J 3:913–917

    PubMed  CAS  Google Scholar 

  86. Wallich R, Bulbuc N, Hammerling GJ, Katzav S, Feldman, M: (1985). Abrogation of metastatic properties of tumor cells by de novo expression of H-2K antigens following H-2 gene transfection. Nature 315:301–305

    Article  PubMed  CAS  Google Scholar 

  87. Welch DR, Tomasovic SP: (1985). Implications of tumor progression on clinical oncology. Clin Expl Metastasis 3:151–188

    Article  CAS  Google Scholar 

  88. Yancopoulos GD, Nisen PD, Tesfaye A., Kohl NE, Goldfarb MP, Alt FW: (1985). N-myc can cooperate with ras to transform normal cells in culture. Proc Natl Acad sci (U.S.A.) Proc Natl Acad sci 82:5455–5459

    Article  PubMed  CAS  Google Scholar 

  89. Yoakum GH, Lechner JF, Gabrielson EW, Korba BE, Malan-Shibley L, Willey JC, Valerio MG, Shamsuddin AM, Trump BF, Harris CC: (1985). Transformation of human bronchial epithelial cells transfected by Harvey ras oncogene. Science 221:1174–1179

    Article  Google Scholar 

  90. Yokota J, Tsunetsugu-Yokota Y, Battifora H, Le Fevre C, Cline MJ: (1986). Alterations of myc, myb, and ras Ha protooncogenes in cancers are frequent and show clinical correlation. Science. 231:261–265

    Article  PubMed  CAS  Google Scholar 

  91. Yuhki N, Hamada J, Kuzumakai N, Takeichi N, Kobayashi H: (1986). Metastatic ability and expression of c-fos oncogene in cell clones of a spontaneous rat mammary tumor. Jpn J Cancer Res (Gann) 77:9–12

    CAS  Google Scholar 

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  1. Ronald H. Goldfarb
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  2. Kenneth W. Brunson
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  1. National Cancer Institute, National Institutes of Health, Bethesda, Md., USA

    Elizabeth K. Weisburger

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Goldfarb, R.H., Brunson, K.W. (1989). Oncogene Products as Potential Therapeutic Targets for Control of Established Metastatic Disease. In: Weisburger, E.K. (eds) Mechanisms of Carcinogenesis. Cancer Growth and Progression, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2526-7_15

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  • DOI: https://doi.org/10.1007/978-94-009-2526-7_15

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