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Oncogenes and their Encoded Products as Targets for Cancer Therapy

  • Chapter
Book cover Mechanisms of Carcinogenesis

Part of the book series: Cancer Growth and Progression ((CAGP,volume 2))

Abstract

Recent advances in the biochemical and molecular understanding of tumor cell function are providing new insights into the alterations in growth regulation which underlie the aberrant proliferation seen in neoplastic disease. Perhaps the best example of these insights comes from the “rediscovery” of oncogenes; these genes represent normal cellular DNA sequences (c-onc or proto-onc genes) which, through particular activating events in carcinogenesis, become “oncogenic” and capable of triggering malignant transformation (reviewed in Varmus (85)). Many of these genes had earlier been described as the transforming (v-onc) genes of RNA tumor viruses (5). Even though the exact details of oncogene regulation and function have yet to be fully defined, early studies have begun to suggest new, unifying themes for normal and abnormal cellular growth control (54, 86).

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  1. Doris L. Slate
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  1. National Cancer Institute, National Institutes of Health, Bethesda, Md., USA

    Elizabeth K. Weisburger

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© 1989 Kluwer Academic Publishers, Dordrecht

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Slate, D.L. (1989). Oncogenes and their Encoded Products as Targets for Cancer Therapy. In: Weisburger, E.K. (eds) Mechanisms of Carcinogenesis. Cancer Growth and Progression, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2526-7_13

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  • DOI: https://doi.org/10.1007/978-94-009-2526-7_13

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