Abstract
The molecular interactions between nucleic acids bases (using nucleosides as a model molecule) and the methylating carcinogen dimethyl sulfate (DMS) as well as those between their methylation products and anticarcinogen cis-Pt(NH3)2Cl2 (cisplatin) have been studied by Raman, IR and NMR spectroscopies. The aim of this work is to contribute to the study of the molecular mechanism of the cancerogenesis and of the pharmacological action of cisplatin. Localized and delocalized (mispairing) molecular reactivities of 1-methyladenosine (1-MeAdo) and 7-methylguanosine (7-MeGuo) have been related to biological activity, while the interactions of the same molecules with cisplatin have been related to the anticarcinogenic activity of the drug.
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© 1989 Kluwer Academic Publishers
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Morelli, M.A., Bertoluzza, A., Fagnano, C., Tugnoli, V., Tosi, M.R., Barbarella, G. (1989). Raman and NMR Studies on the Molecular Interactions between Electrophilic Reagents and Nucleic Acids Constituents. In: Theophanides, T. (eds) Spectroscopy of Inorganic Bioactivators. NATO ASI Series, vol 280. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2409-3_11
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DOI: https://doi.org/10.1007/978-94-009-2409-3_11
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