Skip to main content

Clinical applications of myocardial contrast echocardiography

  • Chapter
Myocardial Contrast Two-dimensional Echocardiography

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 99))

Abstract

Myocardial perfusion imaging using contrast echocardiography is a new technique that has been reported in animal studies since 1982 [1,2]. It has been shown in animal studies to adequately define the area of perfusion deficits produced by experimental coronary occlusion [2,3], and to closely correlate with the area at risk of infarction after acute coronary occlusion [4–6], Recently, myocardial contrast echocardiography has been increasingly used in conjunction with coronary arteriography and coronary angioplasty in humans, using several echogenic contrast agents and methods of administration (see Table 1). This chapter will summarize the recent clinical developments in this field.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Meltzer RS, Vermeulen HWJ, Valk NK, Verdouw PD, Lancee CT, Roelandt J (1982): New echocardiographic contrast agents: Transmission through the lungs and myocardial perfusion imagnyg. J Cardiovasc Ultrason 1: 277–282.

    Google Scholar 

  2. Armstrong WF, Meuller TM, Kinney EL, Tickner EG, Dillon JC, Feigenbaum H (1982): Assessment of myocardial perfusion abnormalities with contrast-enhanced two-dimensional echocardiography. Circulation 66: 166–173.

    Article  PubMed  CAS  Google Scholar 

  3. Tei C, Sakamaki T, Shah PM, et al. (1983): Myocardial contrast echocardiography: A reproducible technique of myocardial opacification for identifying regional perfusion deficits. Circulation 67: 585–593.

    Article  PubMed  CAS  Google Scholar 

  4. Kaul S, Pandian NG, Okada RD, Pohost GM, Weyman AE (1984): Contrast echocardiography in acute myocardial ischemia, I: In vivo determination of total left ventricular ‘area at risk’. J Am Coll Cardiol 4:1272–1282.

    Article  PubMed  CAS  Google Scholar 

  5. Kaul S, Gillam LD, Weyman AE (1985): Contrast echocardiography in acute myocardial ischemia, II: The effect of site of injection of contrast agents on the estimation of area at risk for necrosis after coronary occlusion. J Am Coll Cardiol 6: 825–830.

    Article  PubMed  CAS  Google Scholar 

  6. Kemper AJ, Force T, Perkins L, Gilfoil M, Parisi AF (1986): In vivo prediction of the transmural extent of experimental acute myocardial infarction using contrast echocardiography. J Am Coll Cardiol 8: 143–149.

    Article  PubMed  CAS  Google Scholar 

  7. Santoso T, Roelandt J, Mansyoer H, Abdurahman N, Meltzer RS, Hugenholtz PG (1985): Myocardial perfusion imaging in humans by contrast echocardiography using polygelin colloid solution. J Am Coll Cardiol 6: 612–620.

    Article  PubMed  CAS  Google Scholar 

  8. Feinstein SB, Lang RM, Dick C, et al. (1988): Contrast echocardiography during coronary arteriography in humans: Perfusion and anatomic studies. J Am Coll Cardiol 11: 59–65.

    Article  PubMed  CAS  Google Scholar 

  9. Griffin B, Timmis AD, Sowton E (1987): Contrast perfusion echocardiography: Distribution and reproducibility of myocardial contrast enhancement in coronary artery disease. Am J Cardiol 60: 538–543.

    Article  PubMed  CAS  Google Scholar 

  10. Lang RM, Feinstein SB, Feldman T, Neumann A, Chua KG, Borow KM (1986): Contrast echocardiography for evaluation of myocardial perfusion:, Effects of coronary angioplasty. J Am Coll Cardiol 8: 232–235.

    Article  PubMed  CAS  Google Scholar 

  11. Goldman ME, Mindich BP (1984): Intraoperative cardioplegic contrast echocardiography for assessing myocardial perfusion during open heart surgery. J Am Coll Cardiol 4: 1029–1034.

    Article  PubMed  CAS  Google Scholar 

  12. Yasui K, Matsumoto M, Maeda T, et al. (1982): Estimation of intramyocardial blood flow distribution with contrast echomyocardiography (abstract). Circulation 66 (suppl II): 11–28.

    Google Scholar 

  13. Smith JS, Feinstein SB, Kapelanski D, et al. (1986): Intraoperative determination of myocardial perfusion using contrast echocardiography (abstract). Anesthesiology 65: A27.

    Article  Google Scholar 

  14. Ten Cate FJ, Drury JK, Meerbaum S, Noordsy J, Feinstein S, Shah PM, Corday E (1984): Myocardial contrast two-dimensional echocardiography: Experimental examination at different coronary blood flow levels. J Am Coll Cardiol 3: 1219–1226.

    Article  PubMed  Google Scholar 

  15. Tei C, Kondo S, Meerbaum S, et al. (1984): Correlation of myocardial echo contrast disappearance rate (‘washout’) and severity of experimental coronary stenosis. J Am Coll Cardiol 3: 39–46.

    Article  PubMed  CAS  Google Scholar 

  16. Matsumoto M, Yasui K, Shimazu T, et al. (1984): Evaluation of severity of coronary stenosis by contrast echomyocardiography in clinical cases (abstract). Circulation 66 (suppl n): II–393.

    Google Scholar 

  17. Ten Cate FJ, Cornel JH, Serruys PW, Vletter WB, Reiber JC (1987): Quantitative myocardial perfusion imaging using contrast two-dimensional echocardiography (abstract). J Am Coll Cardiol 9: 112A.

    Google Scholar 

  18. Berwing K, Schlepper M, Kremer P, Bahavar H (1988): Comparison of three methods of evaluating coronary obstructive lesions: Quantitative contrast echocardiography, quantitative coronary angiography and left ventricular regional wall motion (abstract). Circulation 78 (suppl II): II–567.

    Google Scholar 

  19. Griffin B, Timmis AD, Henderson RA, Sowton E (1987): Contrast perfusion echocardiography: Identification of area at risk of dyskinesis during percutaneous transluminal coronary angioplasty. Am Heart J 114: 497–502.

    Article  PubMed  CAS  Google Scholar 

  20. Reisner SA, Ong LS, Lichtenberg GS, Shapiro JR, Amico AF, Allen MN, Meltzer RS (1989): Quantitative assessment of the immediate results of coronary angioplasty by myocardial contrast echocardiography J Am Coll Cardiol 13: 852–6.

    Article  PubMed  CAS  Google Scholar 

  21. Zotz RJ, Kann B (1987): Evaluation of PTCA by video-intensitometric analysis of contrast echocardiograms (abstract). Circulation 76 (suppl IV) IV: 505.

    Google Scholar 

  22. Ito H, Tomooka T, Morioka T, Higashino Y, Katoh O, Minamino T (1988): Contrast echocardiography for assessment of regional myocardial perfusion: Effect of coronary stenosis and angioplasty. Circulation 78 (suppl II) II: 567.

    Google Scholar 

  23. Grill HP, Brinker JA, Cadden J, Walford GD, Midei M, Flaherty JT, Weiss JL (1988): Contrast echocardiographic demonstration of coronary collateral flow in humans (abstract). Circulation 78 (suppl II): II–463.

    Google Scholar 

  24. Ten Cate FJ, Cornel JH, Widimsky P, Serruys PW, Vletter WB, Mittertreiner WH (1987): Effect of papaverine administration on myocardial echocontrast distribution. Am Heart J 114: 1248–1249.

    Article  PubMed  Google Scholar 

  25. Cheirif J, Zoghbi WA, Raizner AE, et al. (1988): Assessment of myocardial perfusion in humans by contrast echocardiography, I: Evaluation of regional coronary reserve by peak contrast intensity. J Am Coll Cardiol 11: 735–743.

    Article  PubMed  CAS  Google Scholar 

  26. Keller MW, Glasheen W, Smucker ML, Burwell LR, Watson DD, Kaul S (1988). J Am Coll Cardiol 12: 925–34.

    Article  PubMed  CAS  Google Scholar 

  27. Moore CA, Smucker ML, Kaul S (1986): Myocardial contrast echocardiography in humans, I: Safety — A comparison with routine coronary arteriography. J Am Coll Cardiol 8:1066–1072.

    Article  PubMed  CAS  Google Scholar 

  28. Lang RM, Borow KM, Neumann A, Al-Sadir J, Feinstein SB (1987): Effect of intracoro-nary injections of sonicated microbubbles on left ventricular contractility. Am J Cardiol 60: 166–71.

    Article  PubMed  CAS  Google Scholar 

  29. Reisner SA, Ong LS, Shapiro JR, Lichtenberg GS, Amico AF, Allen MN, Meltzer RS (1988): Efficacy and safety of myocardial perfusion imaging using intracoronary sonicated albumin in humans (abstract). Circulation 78 (suppl II): 11–565.

    Google Scholar 

  30. Shapiro JR, Xie F, Meltzer RS (1988): Myocardial contrast two-dimensional echocardiography: Dose myocardial effect relations of intracoronary microbubbles. J Am Coll Cardiol 12: 765–771.

    Article  PubMed  CAS  Google Scholar 

  31. Zwehl W, Areeda J, Schwartz G, Feinstein S, Ong K, Meerbaum S (1984): Physical factors influencing quantitation of two-dimensional contrast echo amplitudes. J Am Coll Cardiol 4: 157–164.

    Article  PubMed  CAS  Google Scholar 

  32. Franken G, Zeitler E (1978): Experience with mechanical contrast medium injection at selective coronary angiography. Cardiovasc Radiol 1:21–6.

    Article  CAS  Google Scholar 

  33. Monaghan MJ, Quigley PJ, Metcalfe JM, Jewitt DE (1987): Assessment of myocardial perfusion by contrast enhanced digital subtraction echocardiography (abstract). J Am Coll Cardiol 9: 112A.

    Google Scholar 

  34. Armstrong WF, West SR, Dillon JC, Feigenbaum H (1984): Assessment of location and size of myocardial infarction with contrast-enhanced echocardiography. II. Application of digital imaging techniques. J Am Coll Cardiol 4: 141–148.

    Article  PubMed  CAS  Google Scholar 

  35. Ong K, Maurer G, Feinstein S, Zwehl W, Meerbaum S, Corday E (1984): Computer methods for myocardial contrast two-dimensional echocardiography. J Am Coll Cardiol 3: 1212–1218.

    Article  PubMed  CAS  Google Scholar 

  36. Keller MW, Glasheen W, Teja K, Gear A, Kaul S (1988): Myocardial contrast echocardiography without significant hemodynamic effects or reactive hyperemia: A major advantage in the imaging of regional myocardial perfusion. J Am Coll Cardiol 12: 1039–1047.

    Article  PubMed  CAS  Google Scholar 

  37. Berwing K, Schlepper M, Kremer P, Bahawar H (1987): Comparison of myocardial perfusion determined by contrast echocardiography with left ventricular regional function in patients (abstract). Circulation 76 (suppl IV): IV–506.

    Google Scholar 

  38. Dick CD, Feinstein SB (1987): Temporal and regional heterogeneity of human myocardial perfusion with contrast echocardiography (abstract). Clin Research 35: 274A.

    Google Scholar 

  39. Nanto S, Lim YJ, Ikeda T, Masuyama T, Matsumara Y, Okazaki Y (1987): Visualization of subendocardial ischemia by myocardial contrast echocardiography in man (abstract). Circulation 76 (suppl IV): IV–506.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Kluwer Academic Publishers, Dordrecht

About this chapter

Cite this chapter

Shapiro, J.R., Reisner, S.A., Meltzer, R.S. (1989). Clinical applications of myocardial contrast echocardiography. In: Meerbaum, S., Meltzer, R.S. (eds) Myocardial Contrast Two-dimensional Echocardiography. Developments in Cardiovascular Medicine, vol 99. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2346-1_12

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-2346-1_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7556-5

  • Online ISBN: 978-94-009-2346-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics