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Alteration of the genome as a method to increase diversity in animal germplasm resources

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Book cover Biotic Diversity and Germplasm Preservation, Global Imperatives

Part of the book series: Beltsville Symposia in Agricultural Research ((BSAR,volume 13))

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Abstract

During this decade, methods have been developed to introduce new and sometimes unique genetic information into animals as diverse as Drosophila and swine. These techniques theoretically could be applied to any animal. The methods currently practiced utilize recombinant DNA technology to modify existing genetic coding sequences before introduction into embryos. If the foreign gene (transgene) is incorporated into the genome of the one-cell embryo, all of the cells of the mature transgenic animal, including its germ cells, will contain the transgene. Transgenic animals have been used successfully to study developmental and tissue-specific gene expressions, genetic regulation of the immune system, oncogenesis, globin regulation, and pancreatic function. Practical applications of the transgenic model are currently focused on enhancing disease resistance, improving growth characteristics, producing pharmaceuticals, and creating models for the study of human disease. Low efficiency of gene insertion has restricted widespread use of the transgenic model to Drosophila and mice, though transgenic farm animals have been produced. Improved efficiency of gene insertion and improved regulation of gene function will provide a means of specifically introducing genetic alterations into the gene pool and thereby increasing genetic diversity in the animal kingdom.

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Authors and Affiliations

  1. Reproduction Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, Maryland, 20705, USA

    Robert J. Wall & Caird E. Rexroad Jr.

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  1. Robert J. Wall
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  2. Caird E. Rexroad Jr.
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Editors and Affiliations

  1. Systematic Entomology Laboratory, USDA, ARS, Building 003, 20705, Beltsvikke, MD, USA

    Lloyd V. Knutson (Research Entomologist) (Research Entomologist)

  2. Germplasm Services Laboratory, USDA, ARS, Room 127, Building 001, BARC-W, 20705, Beltsville, MD, USA

    Allan K. Stoner (Research Leader) (Research Leader)

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© 1989 Kluwer Academic Publishers

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Wall, R.J., Rexroad, C.E. (1989). Alteration of the genome as a method to increase diversity in animal germplasm resources. In: Knutson, L.V., Stoner, A.K. (eds) Biotic Diversity and Germplasm Preservation, Global Imperatives. Beltsville Symposia in Agricultural Research, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2333-1_14

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  • DOI: https://doi.org/10.1007/978-94-009-2333-1_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7549-7

  • Online ISBN: 978-94-009-2333-1

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