Abstract
The majority of N-nitroso compounds (NNO) are mutagenic and/or carcinogenic [1]. There have been a number of direct and indirect demonstrations of the formation of nitrosamines in vivo in experimental animals and these have been reviewed by Archer [2]. Some N-nitroso compounds, such as N-nitrosoproline, are not readily metabolized and consequently appear unchanged in the urine [3]. Thus the in vivo formation of NNO in man has been demonstrated by the appearance of N-nitrosoproline in the urine after ingestion of nitrate and proline [4]. The total amount of NNO in the urine has therefore been regarded as a measure of the total in vivo formation of N-nitroso compound.
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References
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© 1990 Kluwer Academic Publishers
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Smith, P.L.R., Gillatt, P.N., Walters, C.L. (1990). Early Detection of Patients at High Risk of Developing Gastric Cancer. In: Reed, P.I., Carboni, M., Johnston, B.J., Guadagni, S. (eds) New Trends in Gastric Cancer. Developments in Oncology, vol 59. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2167-2_5
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DOI: https://doi.org/10.1007/978-94-009-2167-2_5
Publisher Name: Springer, Dordrecht
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