Abstract
The process of protein hydration comprises a rich set of events characterized by changes in connectivity. Water clusters form at low hydration, below 0.1 h (g of water per g of protein). At 0.15 h percolation pathways emerge. Condensation of the solvent to complete monolayer coverage begins at 0.25 h. Concomitant with this, there is unfreezing of surface motions. Both protonic percolation and unfreezing of the surface motions appear to be important for enzymic catalysis by lysozyme. Protonic percolation has been observed for purple membrane fragments and is possibly also of biological significance.
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© 1990 Kluwer Academic Publishers
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Rupley, J.A. (1990). Protein Hydration, Protonic Percolation, and Connectivity. In: Stanley, H.E., Ostrowsky, N. (eds) Correlations and Connectivity. NATO ASI Series, vol 188. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2157-3_25
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DOI: https://doi.org/10.1007/978-94-009-2157-3_25
Publisher Name: Springer, Dordrecht
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