Abstract
Rapid metabolite production necessitates rapid fluxes of both carbon and energy through the metabolic system of an organism. The capacity to process these fluxes rapidly appears to be inversely related to the growth efficiency of the producing organism. In general three main classes of metabolites may be distinguished. Exopolysaccharides, where both the oxidation state and the rate of production appears to be inversely related to the growth efficiency of the producing organism and maximal production occurs when both carbon and energy flux is integrated. These considerations should be taken into account when molecular genetics is used to bring about changes in the chemical composition/properties of these molecules. The production of metabolites such as organic acids is accompanied by the net generation of reducing equivalents and/or ATP and their rate of production may be limited by the capacity of the producing organism to dissipate this energy. For metabolites like biosurfactants that contain both sugar and fatty acid moieties production from a single carbon source is unfavourable and dual substrates may offer a means of boosting both specific rates of production as well as final broth concentrations. These considerations suggest that there may be scope for improving the specific rates of production of existing metabolites such as amino acids and PHA by exploiting organisms with growth efficiencies that are lower than those of process organisms currently in use.
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Linton, J.D. (1990). Physiology of Exopolysaccharide Production. In: Dawes, E.A. (eds) Novel Biodegradable Microbial Polymers. NATO ASI Series, vol 186. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2129-0_26
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DOI: https://doi.org/10.1007/978-94-009-2129-0_26
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