Abstract
Activation of the hypothalamus-hypophisys-adrenal axis by the CNS, is central to the stress response. The experiments presented here, were aimed to study some of the responses to different kinds of stress in rats of different ages. Changes in corticosterone (Gc) secretion were studied as an index of adreno-cortical stimulation and changes in catecholamine metabolism were taken as an index of activation of some cerebral pathways. Aged rats presented higher basal Gc secretion and the increase wich followed application of a stressor was similar to or higher than that observed in young rats. No difference was observed in the kinetic of Gc secretion.
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References
Achilli G., Perego C. and Ponzio F. (1985) Application of the Dual-Cell Coulometric detector: a method for assaying monoamines and their metabolites. Anal. Biochem. 148, 1–9
Algeri S., Calderini G., Lomuscio G., Vantini G., Toffano G. and Ponzio F. (1982) Changes with age in rat central monoaminergic system responses to cold stress. Neurobiol Aging 3, 237–242
Algeri S., Achilli G., Calderini G., Perego C, Ponzio F. and Toffano G. (1987) Age-related changes in metabolic responses to chronic monoamine depletion in central dopaminergic and serotonergic system of rats treared with reserpine. Neurobiol Aging 8, 61–66
Algeri S., Calderini G., Lomuscio G., Rocchetti M., Sacchetti G., Toffano G. and Ponzio F. (1988) Differential response to immobilization stress of striatal dopaminergic and hippocampal noradrenergic system in aged rats. Neurobiol Aging 9, 213–216
Carlsson A. and Lindqvist M. (1973) In vivo measurements of tryptophan and tyrosine hydroxylase activities in mouse brain. J. Neural Trasm. 34, 79–91
Curzon G., Hutson P. H. and Knott P. J., (1979) Voltammetry in vivo: Effect of stressfull manipulations and drugs on the caudate nucleus of the rat. Br. J. Pharmacol. 66, 127P–128P
Fadda F., Argiolas A., Melis M. R., Tissari A. H., Onali P. L., and Gessa G.L. (1978) Stress-induced increse in 3, 4-dihydroxyphenylacetic acid (DOPAC) levels in the cerebral cortex and in N. Accumbens: reversal by Diazepam. Life Science 23, 2219–2224
Gallagher M. and Pelleymounter M. A. (1988) An age-related spatial learning deficit: choline uptake distinguishes ‘impaired’ and ‘unimpaired’ rats. Neurobiol. Aging 9, 363–369
Glavin G. B. (1985) Stress and brain noradrenaline: a review. Neurosci.Biobehav. Rev. 9, 233–243
Ida Y., Tanaka M., Kohono Y., Nakagawa R., Iimori K., Tsuda A., Hoaky Y. and Nagasaki N. (1982) Effect of age and stress on regional noradrenaline metabolism in the rat brain. Neurobiol Aging 3, 233–236
Meaney M. J., Aitken D. H., van Berkel C, Bhatnagar S., Sapolsky R. M. (1988) Effect of neonatal handling on age-related impairments associated with the hippocampus. Science 239, 766–768
Sapolsky R. M., Krey L. C, McEwen B. S. (1983) The adrenocortical stress-response in the aged male rat impairment of recovery from stress. Exp. Gerontol. 18, 55–64
Shimizu K., Amagaya S. and Ogihara Y. (1983) Analysis of corticosterone in the serum of mice and rats using high-performance liquid chromatografy. J. Chromatog. 272, 170–175
Thierry A. M., Tassin J. P., Blanc G. and Glowinski J. (1976) Selective activation of the mesocortical DA system by stress. Nature 263, 242–244.
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© 1990 Kluwer Academic Publishers
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Algeri, S., Biagini, L., Garofalo, P., Marconi, M., Pitsikas, N., Sacchetti, G. (1990). Adrenocortical and Central Monoaminergic System Responses to Different Stressful Situations in Young and Senescent Rats. In: Puglisi-Allegra, S., Oliverio, A. (eds) Psychobiology of Stress. NATO ASI Series, vol 54. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1990-7_16
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DOI: https://doi.org/10.1007/978-94-009-1990-7_16
Publisher Name: Springer, Dordrecht
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