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Crohn’s Disease in Children and Adolescents: Diminished Growth Velocity

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Book cover Inflammatory Bowel Diseases 1990

Part of the book series: Developments in Gastroenterology ((DIGA,volume 11))

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Abstract

Crohn’s disease is a chronic, relapsing inflammatory illness that may affect any portion of the gastrointestinal system. At least 12% of patients have evidence that the illness started before age 15 (1). Of this group of children and prepubescent adolescents, 20 to 30% demonstrate severe growth retardation. This is usually defined by height less than the 3rd percentile for age, or by height being two standard deviations below the average height for a certain age, or by bone age two years less than chronological age (2–4).

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References

  1. Burbige EJ, Huang SS, Bayless TM. Clinical manifestations of Crohn’s disease in children and adolescents. Pediatrics 1975;55:866–71.

    PubMed  CAS  Google Scholar 

  2. Kirschner BS, Voinchet O., Rosenberg IH. Growth retardations in inflammatory bowel disease. Gastroenterology 1978;75:504–11.

    PubMed  CAS  Google Scholar 

  3. Whitington PE, Barnes HV, Bayless TM. Medical management of Crohn’s disease in adolescence. Gastroenterology 1977;72:1338–42.

    Google Scholar 

  4. Gryboski JD, Spiro HM. Prognosis in children with Crohn’s disease. Gastroenterology 1978;74:807–16.

    PubMed  CAS  Google Scholar 

  5. Kanof ME, Lake AM, Bayless TM. Decreased height velocity in children and adolescents before the diagnosis of Crohn’s disease. 1988;95:1523–7.

    Google Scholar 

  6. Thomas BM, Mundy GR, Chambers TJ. Tumor necrosis factors alpha and beta induce osteoblastic cells to stimulate osteoclastic bone resorption. J. Immunol. 1987;138:775–9.

    Google Scholar 

  7. Stashenko P. Dewhirts FE, Peros WJ, Kent RL, Ago JM. Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption. J. Immunol. 1987;138:1464–8.

    PubMed  CAS  Google Scholar 

  8. Unterman TG, Phillips LS, Glucocorticoid effects on somatomedins and somatomedin inhibitors. J. Clin. Endocrinol.Metab. 1985;61:618–26.

    Article  PubMed  CAS  Google Scholar 

  9. Vassilopoulou-Sellin R, Lock RI, Oyedeji CO, Saman NA. Cartilage sulfation inhibitor from rat liver curtails growth of embryonic chicken cartilage in vitro. Metabolism 1987;36:89–74.

    Article  PubMed  CAS  Google Scholar 

  10. Centrella M, McCarthy TL, Canalis E. Skeletal tissue and transforming growth factor B. 1988;2:3066–3073.

    Google Scholar 

  11. Motil KJ, Grand RJ, Maletskos CJ, Young VR. The effect of disease, drug and diet on whole body protein metabolism in adolescents with Crohn’s disease and growth failure. J. Pediatr 1982;101:345–51.

    Article  Google Scholar 

  12. Gill BB, Hillemeier AC, Gryboski JD. Fecal alpha 1-antitrypsin clearance in patients with inflammatory bowel disease. J Pediatr. Gastroenterol. Nutr. 1984;3:56–61.

    Article  Google Scholar 

  13. Kelts DG, Grand RJ, Shen G. Watkins JB, Wenlen SH, Boehme C. Nutritional basis of growth failure in children and adolescents with Crohn’s disease. Gastroenterology 1979;76:720–7.

    PubMed  CAS  Google Scholar 

  14. Motil KJ, Grand RJ, Maletskos CJ, Young VR. The effect of disease, drug and diet on whole body protein metabolism in adolescents with Crohn’s disease and growth failure. J. Pediatr. 1982:101:345–51.

    Article  Google Scholar 

  15. Kirschner BS, Klich JR, Kalman SS, deFavaro MV, Rosenberg IH. Reversal of growth retardation in Crohn’s disease with therapy emphasizing oral nutritional restitution. Gastroenterology 1981;80:10–5.

    PubMed  CAS  Google Scholar 

  16. Layden T, Rosenberg J, Nemchausky B, Elson C. Rosenberg I. Reversal of growth arrest in adolescents with Crohn’s disease after parental alimentation. Gastroenterology 1976;70:1017–21.

    PubMed  CAS  Google Scholar 

  17. Lake AM, Kim S, Mathis RK, Walker WA. Influence of preoperative parental alimentation on post-operative growth in adolescent Crohn’s disease. J. Pediatr.Gastroenterol.Nutr. 1985;4:182–6.

    Article  PubMed  CAS  Google Scholar 

  18. Belli DC, Seidman E. Bouthillier L, et al. Chronic intermittent elemental diet improves growth failure in children with Crohn’s disease. Gastroenterology 1988;94:603–10.

    PubMed  CAS  Google Scholar 

  19. Beeken W. Absorptive defects in young people with regional enteritis. Pediatric 1973;52:60–74.

    Google Scholar 

  20. McClain C, Soritor C, Zieve L. Zinc deficiency: a complication of Crohn’s disease. Gastroenterolgoy 1980;78:272–9.

    CAS  Google Scholar 

  21. Farthing MJG, Campbell CA, Walker-Smith JA, Edwards CRW, Rees LH, Dawson Am. Nocturnal growth hormone and gonadotrophin secretion in growth retarded children with Crohn’s disease. Gut 1981;22:933–8.

    Article  PubMed  CAS  Google Scholar 

  22. Kirschner BS, Sutton MM. Somatomedin-C levels in growth-impaired children and adolescents with chronic inflammatory bowel disease. Gastroenterology 1986;91:830–6.

    PubMed  CAS  Google Scholar 

  23. Kelts DG, Grand RJ, Shen G. Watkins JB, Wenlen SH, Boehme C. Nutritional basis of growth failure in children and adolescents with Crohn’s disease. Gastroenterology 1979;76:720–7.

    PubMed  CAS  Google Scholar 

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© 1990 Kluwer Academic Publishers

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Bayless, T.M., Kanof, M. (1990). Crohn’s Disease in Children and Adolescents: Diminished Growth Velocity. In: Rachmilewitz, D., Zimmerman, J. (eds) Inflammatory Bowel Diseases 1990. Developments in Gastroenterology, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1980-8_16

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  • DOI: https://doi.org/10.1007/978-94-009-1980-8_16

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7385-1

  • Online ISBN: 978-94-009-1980-8

  • eBook Packages: Springer Book Archive

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