Abstract
Over the years a large number of animal models of IBD have been put forth. The stimuli used to promote inflammation in the models include infectious agents, immune manipulation, toxic compounds and tissue homogenates from IBD patients. Although all of the models are successful models of intestinal inflammation it is hard to single out one as being a more successful model of IBD because we have no specific markers of IBD for the model to mimic. Progress in the development of animal models awaits the better definition of characteristics specific to IBD.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Strober, W. (1985) ‘Animal Models of Inflammatory Bowel Disease—An Overview’. Dig. Dis. and Sci. 30(12):3S–10S.
MacDermott, RP. and Stenson, WF. (1986) ‘The Immunology of Idiopathic Inflammatory Bowel Disease’. Hosp. Pract. 21:97.
Chalifoux, LV., Brieland, JK. and King, NW. (1985) ‘Evolution and Natural History of Colonic Disease in Cotton-top Tamarins (Saguinus oedipus)’. Dig. Dis. Sci. 12:54S.
Morgan, KL. (1987) ‘Johne’s and Crohn’s. Chronic Inflammation Bowel Diseases of Infectious Etiology?’ Lancet i:1017–1019.
Mitchell, DN. and Rees, RJW. (1969) ‘Agent Transmissible from Crohn’s Disease Tissue’. Lancet 2:489–490.
Chiodini, RJ. (1989) ‘Crohn’s Disease and the Mycobacterioses: a Review and Comparison of Two Disease Entities’. 2(1):90–117.
Graham, DY., Markesich, DC. and Yoshimura, HH. (1987) “Mycobacteria and Inflammatory Bowel Disease: Results of Culture’. Gastro. 92:436–442.
Kirsner, JB. (1961) ‘Experimental “colitis” with Particular Reference to Hypersensitivity Reactions in the Colon’. Gastro. 40:307–312.
Kraft, SC., Fitch, FW. and Kirsner, JB. (1963) ‘Histologic and Immunolohistochemical Features of Auer “colitis” in rabbits’. Am. J. Path. 43:913–923.
Glick, ME. and Falchuk, ZM. (1981) ‘Dinitrochlorobenzene-induced Colitis in the Guinea-pig: Studies of Colonic Lamina Propria Lymphocytes’. Gut 22:120–125.
Sartor, BR., Cromartie, WJ., Powell DW., and Schwab, JH. (1985) ‘Granulomatous Enterocolitis Induced in Rats by Purified Bacterial Cell Wall Fragments’. Gastro. 89:587–595.
Sharon, P., and Stenson, WF. (1985) ‘Metabolism of Arachidonic Acid in Acetic Acid Colitis in Rats: Similarity to Human Inflammatory Bowel Disease’. Gastro. 88:55.
Morris, GP., Beck, PL., Herridge, MS., Depew, WT., Szewczuk, MR. and Wallace JL. (1989) ‘Hapten-Induced Model of Chronic Inflammation and Ulceration in the Rat Colon’. Gastro. 96:795–803.
Allgayer, H., DeSchryver, K., and Stenson, WF. (1989) ‘Treatment with 16,16′ Dimethylprostaglandin E2 Before and After Induction of Colitis with Trinitrobenzene Sulfonic Acid in Rats Decreased Inflammation’. Gastro. 96:1290–1300.
Wallace, JL., MacNaughton, WK., Morris, GP. and Beck, PL. (1989) ‘Inhibition of Leukotriene Synthesis Markedly Accelerates Healing in a Rat Model in Inflammatory Bowel Disease’. Gastro. 96:29–36.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Kluwer Academic Publishers
About this chapter
Cite this chapter
Stenson, W.F. (1990). Animal Models of Inflammatory Bowel Disease. In: Rachmilewitz, D., Zimmerman, J. (eds) Inflammatory Bowel Diseases 1990. Developments in Gastroenterology, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1980-8_10
Download citation
DOI: https://doi.org/10.1007/978-94-009-1980-8_10
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7385-1
Online ISBN: 978-94-009-1980-8
eBook Packages: Springer Book Archive