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Formate Dehydrogenase: Microbiology, Biochemistry and Genetics

  • Chapter
Autotrophic Microbiology and One-Carbon Metabolism

Part of the book series: Advances in Autotrophic Microbiology and One-Carbon Metabolism ((AMOC,volume 1))

Abstract

Formate is produced or consumed in various reactions essential for metabolic pathways of diverse organisms. It is commonly formed as a byproduct of anabolism where it is further oxidized by formate dehydrogenase to carbon dioxide or activated to formyltetrahydrofolate as a one-carbon substrate for biosynthetic reactions (Thauer et al. 1977a). A diversity of microorganisms produce or consume formate in energy yielding pathways. This chapter focuses on the reversible two-electron oxidation of formate (HCOO− = CO2 + H+ + 2e−) catalyzed by formate dehydrogenases from eubacteria, archaeobacteria and eucaryotic yeasts.

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Authors and Affiliations

  1. Department of Anaerobic Microbiology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, 24061, USA

    James G. Ferry

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  1. James G. Ferry
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  1. The University, Dundee, Scotland

    Geoff A. Codd

  2. University of Groningen, The Netherlands

    Lubbert Dijkhuizen

  3. Ohio State University, Columbus, Ohio, USA

    F. Robert Tabita

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© 1990 Kluwer Academic Publishers

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Ferry, J.G. (1990). Formate Dehydrogenase: Microbiology, Biochemistry and Genetics. In: Codd, G.A., Dijkhuizen, L., Tabita, F.R. (eds) Autotrophic Microbiology and One-Carbon Metabolism. Advances in Autotrophic Microbiology and One-Carbon Metabolism, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1978-5_5

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  • DOI: https://doi.org/10.1007/978-94-009-1978-5_5

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