Abstract
A series of studies have been carried out into the effect of d-fenfluramine on various aspects of eating behaviour, feeding patterns and hunger motivation in adult human subjects - lean and obese. The objective was to determine the influence of 5-HT manipulation on the control of appetite and the processes of satiation and satiety. D-fenfluramine (2 × 15mg. /day) reduced daily caloric intake by 18–20%, reduced hunger motivation and prevented the return of hunger after a meal. Food intake in a test meal was reduced by 18% and some small meals and snacks were eliminated from the eating repertoire. D-fenfluramine did not suppress the perceived pleasantness of sucrose solutions in lean or obese subjects but intensified the suppressive action of a glucose load on hunger. In obese subjects (BMI - 38.0) d-fenfluramine augmented the satiating power of a mainly carbohydrate or protein meal at a dose level of 0.3mg/kg. In PMS subjects d-fenfluramine prevented the mean rise in body weight (0.8kg) which occurred over the course of the menstrual cycle. The drug did not alter the frequency of symptoms identified by the MDQ.
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© 1990 Kluwer Academic Publishers
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Blundell, J.E., Hill, A.J. (1990). Effect of D-Fenfluramine on Appetite in Lean and Obese Human Subjects and on Changes Associated with PMS (Pre-Menstrual Syndrome). In: Paoletti, R., Vanhoutte, P.M., Brunello, N., Maggi, F.M. (eds) Serotonin. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1912-9_84
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DOI: https://doi.org/10.1007/978-94-009-1912-9_84
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